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Research ArticleBrain

Effects of Aging on Regional Cerebral Blood Flow Assessed By Using Technetium Tc 99m Hexamethylpropyleneamine Oxime Single-Photon Emission Tomography with 3D Stereotactic Surface Projection Analysis

Kazuo Takahashi, Shuhei Yamaguchi, Shotai Kobayashi and Yasushi Yamamoto
American Journal of Neuroradiology September 2005, 26 (8) 2005-2009;
Kazuo Takahashi
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Shuhei Yamaguchi
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Shotai Kobayashi
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Yasushi Yamamoto
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    Fig 1.

    Statistical maps analyzed by 3D SSP. The color of the outer counter corresponds to a Z score of 7.

    A, Relative decreases of rCBF (z score ≦2) in subjects 60–69 years of age compared with rCBF in subjects 50–59 years of age. The most extensive reduction in rCBF was observed in the right anterior cingulate gyrus. There were also decreases in rCBF in the left anterior cingulate gyrus, bilateral posterior cingulate gyri, bilateral medial frontal gyri, bilateral subcallosal gyri, left superior temporal gyrus, and left cuneus.

    B, Relative decreases of rCBF (z score ≦2) in subjects 70–79 years of age compared with rCBF in subjects 60–69 years of age. The most extensive reduction in rCBF was observed in the bilateral anterior cingulate gyri. There were also decreases in rCBF in the left inferior frontal gyrus, left subcallosal gyrus, left supramarginal gyrus, and left superior temporal gyrus.

    C, Relative decreases of rCBFs (z score ≦2) in subjects 70–79 years of age compared with rCBF in subjects 50–59 years of age. The most extensive reduction in rCBF was observed in the bilateral anterior cingulate gyri. There were also decreases in rCBF in the left inferior frontal gyrus, left subcallosal gyrus, left supramarginal gyrus, and left superior temporal gyrus.

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    TABLE 1:

    Mean age, verbal intelligence, and SDS in each age group

    Age group (y)50–5960–6970–79
    Number (M:F)10 (4:6)12 (7:5)9 (5:4)
    Mean age (y)55.2 ± 3.063.8 ± 2.973.2 ± 2.4
    Okabe’s Scale, total48.9 ± 3.047.0 ± 5.745.4 ± 6.9
        Information18.4 ± 1.617.5 ± 1.716.4 ± 1.9
        Mental control14.5 ± 1.612.4 ± 3.312.8 ± 2.9
        Digit span9.0 ± 1.68.9 ± 1.59.2 ± 0.7
        Associate learning7.0 ± 3.98.2 ± 3.67.0 ± 3.6
    SDS30.8 ± 5.928.9 ± 4.329.7 ± 5.7
    • Note.—Okabe Scale indicates Okabe’s Simplified Intelligence Scale (60-point scale); SDS, Zung Self-Rating Depression Scale (80-point scale).

    • View popup
    TABLE 2:

    Mean z score for each region between each age generation

    Relative Decrease of rCBF, Age (y)
    60–69 vs 50–5970–79 vs 60–6970–79 vs 50–59
    Superior frontal gyrus
        L0.80 ± 0.511.59 ± 0.450.64 ± 0.46
        R0.73 ± 0.591.49 ± 0.350.67 ± 0.41
    Middle frontal gyrus
        L0.60 ± 0.431.37 ± 0.320.99 ± 0.58
        R0.66 ± 0.531.49 ± 0.440.66 ± 0.48
    Inferior frontal gyrus
        L0.71 ± 0.531.97 ± 0.571.53 ± 0.72
        R0.53 ± 0.371.39 ± 0.381.14 ± 0.64
    Medial frontal gyrus
        L1.38 ± 0.841.62 ± 0.581.33 ± 0.99
        R1.37 ± 0.941.30 ± 0.161.37 ± 0.97
    Subcallosal gyrus
        L1.30 ± 1.042.08 ± 0.541.73 ± 0.59
        R1.47 ± 1.111.22 ± 0.130.83 ± 0.37
    Superior parietal lobule
        L0.24 ± 0.171.27 ± 0.170
        R000
    Inferior parietal lobule
        L0.12 ± 0.121.50 ± 0.350.63 ± 0.48
        R0.63 ± 0.551.12 ± 0.060.56 ± 0.40
    Superior temporal gyrus
        L1.19 ± 0.721.61 ± 0.431.97 ± 0.82
        R1.03 ± 0.691.37 ± 0.241.33 ± 0.96
    Middle temporal gyrus
        L0.95 ± 0.741.44 ± 0.341.13 ± 0.72
        R0.42 ± 0.281.47 ± 0.270.82 ± 0.69
    Inferior temporal gyrus
        L0.76 ± 0.421.56 ± 0.470.82 ± 0.45
        R0.92 ± 0.661.27 ± 0.191.20 ± 0.65
    Cuneus
        L1.29 ± 0.9200.71 ± 0.63
        R0.93 ± 0.741.08 ± 0.040.36 ± 0.28
    Lingual gyrus
        L0.70 ± 0.5800.84 ± 0.55
        R0.49 ± 0.471.39 ± 0.250.70 ± 0.38
    Anterior cingulate gyrus
        L1.55 ± 0.611.87 ± 0.592.51 ± 0.81
        R1.79 ± 0.732.02 ± 0.602.89 ± 0.99
    Posterior cingulate gyrus
        L1.31 ± 1.111.40 ± 0.271.42 ± 0.70
        R1.20 ± 0.811.56 ± 0.261.51 ± 0.48
    Parahippocampal gyrus
        L0.44 ± 0.241.43 ± 0.290.97 ± 0.52
        R1.26 ± 0.651.73 ± 0.590.78 ± 0.45
    Superior occipital gyrus
        L0.06 ± 000
        R0.76 ± 0.2800.29 ± 0.15
    Middle occipital gyrus
        L0.47 ± 0.4400.45 ± 0.19
        R0.68 ± 0.3900.56 ± 0.45
    Inferior occipital gyrus
        L000
        R0.05 ± 000
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American Journal of Neuroradiology: 26 (8)
American Journal of Neuroradiology
Vol. 26, Issue 8
1 Sep 2005
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Effects of Aging on Regional Cerebral Blood Flow Assessed By Using Technetium Tc 99m Hexamethylpropyleneamine Oxime Single-Photon Emission Tomography with 3D Stereotactic Surface Projection Analysis
Kazuo Takahashi, Shuhei Yamaguchi, Shotai Kobayashi, Yasushi Yamamoto
American Journal of Neuroradiology Sep 2005, 26 (8) 2005-2009;
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Kazuo Takahashi, Shuhei Yamaguchi, Shotai Kobayashi, Yasushi Yamamoto
Effects of Aging on Regional Cerebral Blood Flow Assessed By Using Technetium Tc 99m Hexamethylpropyleneamine Oxime Single-Photon Emission Tomography with 3D Stereotactic Surface Projection Analysis
American Journal of Neuroradiology Sep 2005, 26 (8) 2005-2009;

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