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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging

Diffusion Tensor Images in Children with Early-Treated, Chronic, Malignant Phenylketonuric: Correlation with Intelligence Assessment

Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Yin-Hsiu Chien, Wuh-Liang Hwu and Hon-Man Liu
American Journal of Neuroradiology October 2004, 25 (9) 1569-1574;
Steven Shinn-Forng Peng
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Wen-Yih Isaac Tseng
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Yin-Hsiu Chien
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Wuh-Liang Hwu
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Hon-Man Liu
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    Fig 1.

    Control subject aged 27 months. Maps of the brain at the level of the lateral ventricular bodies show the right parietal-occipital central white matter with ROIs in the frontoparietal, parietal-occipital, frontal central white matter and in the anterior and posterior corpus callosum.

    A, EV1; B, EV2; C, EV3; D, trace ADC.; E, FA index.

    F, Color-coded fiber orientation. Left-right, anterior-posterior, and superior-inferior directions are associated with pure red, green, and blue, respectively. Combinations of these colors represent oblique fibers.

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    Fig 2.

    PKU patient aged 25 months. Cerebral maps at the level of lateral ventricular bodies.

    A, EV1.

    B, EV2 increases in the bilateral frontal and parietal-occipital central parenchyma, more prominently in the right parietal-occipital central areas (arrows). High-EV2 area is more extensive in bilateral parietal-occipital central areas than in areas shown in Figure 1B.

    C, High EV3 is prominent in parietal-occipital central areas, more on the right (arrows) than the left.

    D, ADCs are diffusely increased, slightly in the bilateral frontal, right frontoparietal, and bilateral parietal-occipital central parenchyma (arrows); the difference is not significant.

    E, FA is reduced in parietal-occipital central white matter, more on the right (arrows) than the left.

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    TABLE 1:

    Results of the Mann-Whitney rank-sum test in patients and control subjects older than 3 years

    PositionP Value
    EV1EV2EV3ADCFA
    Frontoparietal central white matter.37.49.79.64.56
    Parieto-occipital central white.37.02.04.16.02
    Superiofrontal central white matter.431.00.64.87.79
    Anterior portion of corpus callosum.27.10.19.13.08
    Posterior portion of corpus callosum.27.71.79>.99.96
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    TABLE 2:

    Results of the Mann-Whitney rank-sum test in patients and control subjects younger than 3 years

    PositionP Value
    EV1EV2EV3ADCFA
    Frontoparietal central white matter.66>.99>.99>.99>.99
    Parieto-occipital central white>.99.38.66.38.38
    Superiofrontal central white matter.66>.99>.99>.99>.99
    Anterior portion of corpus callosum.66>.99.66.66.66
    Posterior portion of corpus callosum>.99.38.38.19.66
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American Journal of Neuroradiology: 25 (9)
American Journal of Neuroradiology
Vol. 25, Issue 9
1 Oct 2004
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Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Yin-Hsiu Chien, Wuh-Liang Hwu, Hon-Man Liu
Diffusion Tensor Images in Children with Early-Treated, Chronic, Malignant Phenylketonuric: Correlation with Intelligence Assessment
American Journal of Neuroradiology Oct 2004, 25 (9) 1569-1574;

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Diffusion Tensor Images in Children with Early-Treated, Chronic, Malignant Phenylketonuric: Correlation with Intelligence Assessment
Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Yin-Hsiu Chien, Wuh-Liang Hwu, Hon-Man Liu
American Journal of Neuroradiology Oct 2004, 25 (9) 1569-1574;
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