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Research ArticleBRAIN

Multi-Section CT Angiography for Detection of Cerebral Aneurysms

Mehmet Teksam, Alexander McKinney, Sean Casey, Martin Asis, Stephen Kieffer and Charles L. Truwit
American Journal of Neuroradiology October 2004, 25 (9) 1485-1492;
Mehmet Teksam
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Alexander McKinney
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Sean Casey
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Martin Asis
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Stephen Kieffer
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Charles L. Truwit
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  • Fig 1.
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    Fig 1.

    Images obtained in a 45-year-old woman with severe headache.

    A, Unenhanced CT scan of the head shows subarachnoid hemorrhage in the right sylvian fissure (arrow), with mild hydrocephalus. R, right; P, posterior.

    B, 3D volume-rendered image (lateral) shows inferiorly and posteriorly directed saccular aneurysm at the origin of the right posterior communicating artery (arrow). S, superior; I, inferior; P, posterior; A, anterior.

    C, Preoperative right internal carotid digital subtraction angiogram (right anterior oblique projection) shows inferiorly and laterally directed saccular aneurysm at the origin of the posterior communicating artery (arrow).

    D, Intraoperative right internal carotid digital subtraction angiogram (anteroposterior projection) shows successful clip placement in the posterior communicating artery aneurysm.

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    Fig 2.

    Images obtained in a 49-year-old woman with severe headache.

    A, Unenhanced CT scan of the head shows subarachnoid hemorrhage in the left cerebellopontine angle cistern (arrow).

    B, 3D volume-rendered image (posteroanterior) shows superiorly, medially, and anteriorly directed saccular aneurysm (white arrow), which is incorporated into the origin of posterior inferior cerebellar artery (black arrow). S, superior; I, inferior; R, right; L, left.

    C, Preoperative left vertebral artery digital subtraction angiogram (anteroposterior projection) shows saccular aneurysm projecting superiorly and medially at the origin of the posterior inferior cerebellar artery. Note the hypoplastic P1 segment of the posterior cerebral artery.

    D, Intraoperative left vertebral artery digital subtraction angiogram (anteroposterior projection) shows successful clip placement in the aneurysm without occlusion of the posterior inferior cerebellar artery.

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    Fig 3.

    Images obtained in a 41-year-old woman with headache.

    A, 3D volume-rendered image (posteroanterior) shows aneurysm at the origin of the left superior cerebellar artery (arrow). S, superior; I, inferior; R, right; L, left.

    B, Maximum intensity projection image (anteroposterior) shows aneurysm at the origin of the left superior cerebellar artery (arrow). S, superior; I, inferior; R, right; L, left.

    C, Left vertebral artery digital subtraction angiogram (anteroposterior projection) shows aneurysm at the origin of the left superior cerebellar artery. This patient underwent attempted treatment by GDC embolization. However, the aneurysm was thrombosed during the procedure before coil embolization. The patient was followed up and did not have any significant complaint as of the time of this writing.

Tables

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    TABLE 1:

    Characteristics of Patients and Aneurysms

    Aneurysm Size (mm)Aneurysm NumberMean Age ± SD (yr)% FemaleMost Common Indication for MSCTA (%)Most Common Location (%)
    <43650 ±1260Subarachnoid hemorrhage (46)MCA Bi/Tri (19)
    PcoA (14)
    AcoA (14)
    4–106355 ±1160Subarachnoid hemorrhage (58)PcoA (22)
    AcoA (13)
    MCA Bi/Tri (8)
    >102253 ±1445Subarachnoid hemorrhage (41)MCA Bi/Tri (18)
    ICA SC (18)
    PcoA (14)
    • Note.—MSCTA indicates multi-section CT angiography; MCA Bi/Trif, bifurcation/trifurcation of middle cerebral artery; PcoA, posterior communicating artery; AcoA, anterior communicating artery; ICA SC, supraclinoid segment of internal carotid artery.

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    TABLE 2:

    Aneurysm Detection by Multi-Section CT Angiography

    True PositiveFalse Negative
    <4 mm265
    4–10 mm582
    >10 mm220
    Total1067
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    TABLE 3:

    Characteristics of False Positive Evaluations (n=8)

    LocationSize (mm)
    Supraclinoid segment of ICA4
    Supraclinoid segment of ICA3
    Supraclinoid segment of ICA2
    Bi-Trifurcation of MCA4
    P2 segment of PCA6
    ICA (para-ophthalmic)2
    Anterior communicating artery2
    Posterior communicating artery2
    • Note.—ICA indicates internal carotid artery; MCA, middle cerebral artery; PCA, posterior cerebral artery.

    • View popup
    TABLE 4:

    Data for Missed Aneurysms (n = 7)

    LocationSize (mm)Main Reason for Missed Aneurysm
    Posterior communicating artery4Atypical configuration
    Posterior inferior cerebellar artery4Obscured by hemorrhage
    ICA (para-ophthalmic)3Small, adjacent to bone
    Posterior communicating artery2Very small, adjacent to bone
    ICA (cavernous segment)2Very small, adjacent to bone
    Anterior choroidal artery2Very small, adjacent to bone
    Basilar tip1Very small
    • Note.—ICA indicates internal carotid artery.

    • View popup
    TABLE 5:

    Accuracy of Multi-Section CT Angiography on a per-Aneurysm Basis

    Size (mm)SensitivitySpecificityPPVNPVAccuracy
    <40.84(26/31)0.75(15/20)0.840.750.80
    0.72, 0.920.56, 0.880.72, 0.920.56, 0.880.69, 0.91
    4–100.97(58/60)0.83(15/18)0.950.880.94
    (0.91, 0.99)0.64, 0.920.90, 0.980.68, 0.970.88, 0.99
    >101.00(22/22)1.00(15/15)1.001.001.00
    (0.88, 1.00)0.83, 1.000.88, 1.000.83, 1.000.84, 1.00
    • Note.—PPV indicates positive predictive value; NPV, negative predictive value. Numbers in parenthesis indicate numbers of aneurysms, and numbers on second line indicate 95% confidence intervals.

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American Journal of Neuroradiology: 25 (9)
American Journal of Neuroradiology
Vol. 25, Issue 9
1 Oct 2004
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Cite this article
Mehmet Teksam, Alexander McKinney, Sean Casey, Martin Asis, Stephen Kieffer, Charles L. Truwit
Multi-Section CT Angiography for Detection of Cerebral Aneurysms
American Journal of Neuroradiology Oct 2004, 25 (9) 1485-1492;

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Multi-Section CT Angiography for Detection of Cerebral Aneurysms
Mehmet Teksam, Alexander McKinney, Sean Casey, Martin Asis, Stephen Kieffer, Charles L. Truwit
American Journal of Neuroradiology Oct 2004, 25 (9) 1485-1492;
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