Article Figures & Data
Figures
- Fig 1.
Comparison of PSV and Vmean at baseline on the treatment day (Before) and on post-treatment day 1 (After). * indicates P < .001.
- Fig 2.
PSV in all vessels treated in relation to vasospasm on the treatment day (day 0). B indicates baseline. * indicates P < .001. ** indicates .001 ≤ P < .001.
Tables
Case/Age (y)/Sex Medical History Hunt-Hess Grade Fisher Group Aneurysm Location Size (mm) 2/60/M Hypertension 2 2 R Pcomm 10 R ICA, unruptured 7 4/42/F Hypertension 4 3 L ICA 20 Migraines 5/50/F None 3 3 L Pcomm 6 6/50/F Hypertension 3 3 BA 6 7/45/F Migraines 4 3 BA 9 Tobacco abuse L ICA, unruptured 3 R PICA, unruptured 6–7 9/49/F Hypercholesterolemia 2 3 L ICA 8 10/40/F Alcohol abuse 4 3 L Pcomm 8 11/41/F Hypertension 3 3 L MCA 6 12/67/F 4 3 R MCA 5 13/49/M Hypertension, hypercholesterolemia 5 3 L Pcomm 3 14/59/M Tobacco abuse, CAD, hypertension 4 3 L PICA 8 15/65/F None 4 3 Acomm 5 19/55/F Polysubstance abuse, depression, migraine 1 2 R ICA 8 20/53/F None 4 3 L ICA 8 21/44/M Tobacco abuse 4 3 BA 10 22/42/M Tobacco abuse, hypertension 3 3 Acomm 4 23/28/F None 4 3 L MCA 6 24/64/F Hypertension, TIA, hypercholesterolemia 1 2 L Pcomm 3 Note.—Acomm = anterior communicating artery, BA = basilar artery, CAD = coronary artery disease, ICA = internal carotid artery, MCA = middle cerebral artery, Pcomm = posterior communicating artery, PICA = posterior inferior cerebellar artery, TIA = transient ischemic attack.
Case Postbleeding Day Vessel Nicardipine (mg) ICP (cm H2O) Mean Arterial Pressure (mm Hg) Pretreatment Post-Treatment Pretreatment Post-Treatment 2 7 R MCA 3 20 26* 131 132 R ACA 2 4 7 BA 5 15 8 109 107 5 4 R ICA 5 7 7† 136 129 L ICA 5 L Vert 5 6 7 L ICA 5 8 8† 111 108 7 6 R ICA 5 14 13 110 117 BA 3 9 12 R ACA 5 14 11 113 111 L ACA 5 10 4 L ICA 5 14 14 105 105 11 6 L MCA 5 NA NA 130 136 12 6 R ICA 2 11 11† 93 88 L ICA 3 13 13 R ICA 5 L ICA 2.5 12 10 95 100 14 11 L Vert 5 18 13 95 100 15 14 L ICA 2.5 15 12 110 115 19 6 R ICA 2 18 18† 118 118 20 10 L ACA 4 7 7 120 116 L MCA 4 R MCA 4 21 4 R ACA 4 15 15† 120 123 L MCA 3 L ACA 3 6 R ICA 4 13 11 110 112 22 8 L ICA 2 L PCA 1 12 10 96 112 23 9 R ACA 3 14 14 100 105 24 7 L ICA 4 20 15 95 95 Note.—ACA = anterior cerebral artery, BA = basilar artery, MCA = middle cerebral artery, NA = not applicable, PCA = posterior cerebral artery, Vert = vertebral artery.
* Treatment was aborted as a result of sustained elevated ICP.
† ICP was transiently elevated but returned to baseline with opening of the ventriculostomy drain.
Case* Postbleeding Day Vessel Nicardipine (mg) Vasospasm Post-Treatment Neurologic Examination 2 7 R MCA 3 Mild Yes R ACA 2 Mild 4 7 BA 5 Moderate No 5 4 R ICA 5 Mild Yes L ICA 5 Moderate L Vert 5 Moderate 6 7 L ICA 5 Severe No 7 6 R ICA 5 Moderate No BA 3 Moderate 9 12 R ACA 5 Moderate No L ACA 5 Moderate 10 4 L ICA 5 Moderate Yes 11 6 L MCA Moderate Yes 12 6 R ICA 2 Moderate No L ICA 3 Moderate 13 13 R ICA 5 Moderate L ICA 2.5 Mild 14 11 L Vert 5 Mild No 15 14 L ICA 2.5 Mild No 19 6 R ICA 2 Mild Yes L ACA 4 Severe 20 10 L ACA 4 Severe Yes L MCA 4 Severe R MCA 4 Severe R ACA 4 Severe 21 4 L MCA 3 Mild No L MCA 3 Mild L ACA 3 Mild 6 R ICA 4 Severe No L ICA 2 Mild 22 8 L ICA 2 Mild No L PCA 1 Moderate 23 9 R ACA 3 Mild Yes 24 7 L ICA 4 Mild Yes Note.—ACA = anterior cerebral artery, BA = basilar artery, MCA = middle cerebral artery, PCA = posterior cerebral artery, Vert = vertebral artery.
* Case 1 involved the use of papaverine and was not included.
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