Article Figures & Data
Figures
- Fig 1.
Images in a patient with lung carcinoma.
A, Contrast-enhanced T1-weighted MR image demonstrates an enhancing mass adjacent to the central sulcus on the right side.
B, ROIs are placed within the hyperintense vasogenic edema on this T2-weighted MR image and within the corresponding contralateral white matter.
C, MD overlay map renders a mean MD of 0.908 × 10−3 mm2/s.
D, FA overlay map renders a mean FA of 0.114. The peritumoral DTI metrics are consistent with lung metastasis.
- Fig 2.
Scatterplot of FA versus MD demonstrates lack of high correlation between the two variables (R = −0.70). The data in the metastasis group tend to lie within the higher range of MD, when compared with the data in the glioma group (P < .005). Along the FA axis, no such statistically significant discrepancy was observed.
- Fig 3.
Images in a patient with glioblastoma multiforme.
A, Contrast-enhanced T1-weighted MR image demonstrates an enhancing mass in the left temporal lobe that is not clearly high-grade glioma nor clearly metastasis on this conventional MR image.
B, ROIs are placed within the hyperintense vasogenic edema on a T2-weighted MR image and within the corresponding contralateral white matter.
C, MD overlay map renders a mean MD of 0.603 × 10−3 mm2/s.
D, FA overlay map renders a mean FA of 0.301. The peritumoral DTI metrics are consistent with glioblastoma multiforme.
- Fig 4.
Schematics illustrate the factors behind the comparable change in peritumoral FA.
A, Water content and axonal disorganization contributing to decreased FA.
B, Water content contributing to decreased FA
Tables
Patient Diagnosis Peritumoral Signal Abnormality Normal-Appearing White Matter MD (×10−3 mm2/s) FA MD (×10−3 mm2/s) FA 1 Anaplastic astrocytoma 0.602 0.240 0.387 0.529 2 Glioblastoma multiforme 0.586 0.207 0.428 0.390 3 Glioblastoma multiforme 0.764 0.183 0.403 0.421 4 Glioblastoma multiforme 0.789 0.178 0.361 0.486 5 Glioblastoma multiforme 0.460 0.279 0.375 0.501 6 Anaplastic astrocytoma 0.559 0.239 0.398 0.526 7 Glioblastoma multiforme 0.658 0.338 0.382 0.480 8 Anaplastic astrocytoma 0.725 0.190 0.398 0.395 9 Glioblastoma multiforme 0.716 0.206 0.373 0.420 10 Glioblastoma multiforme 0.450 0.248 0.376 0.362 11 Glioblastoma multiforme 0.559 0.373 0.548 0.688 12 Glioblastoma multiforme 0.603 0.301 0.391 0.400 Patient Diagnosis Peritumoral Signal Abnormality Normal-Appearing White Matter MD (×10−3 mm2/s) FA MD (×10−3 mm2/s) FA 1 Breast carcinoma 0.697 0.244 0.399 0.428 2 Melanoma 0.723 0.244 0.415 0.412 3 Breast carcinoma 0.838 0.149 0.436 0.653 4 Testicular carcinoma 0.811 0.194 0.410 0.471 5 Breast carcinoma 0.743 0.174 0.398 0.369 6 Melanoma 0.701 0.183 0.369 0.508 7 Lung carcinoma 0.908 0.114 0.381 0.338 8 Lung carcinoma 0.639 0.229 0.385 0.400 9 Lung carcinoma 0.789 0.168 0.376 0.428 10 Osteosarcoma 0.943 0.182 0.408 0.362 11 Lung carcinoma 1.002 0.157 0.407 0.356 12 Undifferentiated sarcoma 0.788 0.140 0.387 0.404
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