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Research ArticleBrain

MR Imaging Enhancement Patterns as Predictors of Hemorrhagic Transformation in Acute Ischemic Stroke

Katie D. Vo, Fernando Santiago, Weili Lin, Chung Y. Hsu, Yueh Lee and Jin-Moo Lee
American Journal of Neuroradiology April 2003, 24 (4) 674-679;
Katie D. Vo
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Fernando Santiago
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Weili Lin
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Chung Y. Hsu
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Yueh Lee
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Jin-Moo Lee
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  • Fig 1.
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    Fig 1.

    In three patients, initial MR images demonstrate parenchymal enhancement within the area of ischemia. All three patients subsequently developed HT: Patients 6 and 2 developed large SHs (detected with CT), while patient 5 developed a small AH (detected with T2*-weighted MR imaging). F/u indicates follow-up; T1WI, T1-weighted image.

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    Fig 2.

    Initial MR images show vascular enhancement in the territory of the right MCA (left). This patient developed a petechial AH, which was detected on T2*- and T2-weighted images (right) obtained 1 week later. T1WI indicates T1-weighted image; T2WI, T2-weighted image

Tables

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    TABLE 1:

    Demographic, clinical, treatment, and imaging data

    Pt/Age, y/SexIV tPAInitial NIHSS scoreTime to First MR Study, h:minInitial DWI Volume, cm3Enhancement PatternContrast Agent Dose†Follow-Up Studies*Hemorrhage
    1/57/FYes145:0044.73Vascular1×MR3, CTAH
    2/71/MYes124:0062.73Parenchymal and vascular1×CTSH
    3/66/MYes193:30117.58Vascular1×MR3, CTNone
    4/72/FYes164:0017.65Vascular1×MR3None
    5/56/MYes103:0018.59Parenchymal and vascular1×MR3, CTAH
    6/68/MYes155:3028.09Parenchymal and vascular1×MR3, CTSH
    7/63/FNo146:0033.66Vascular2×MR3, MR7AH
    8/70/MNo166:3058.07Vascular2×MR3, MR7None
    9/67/FNo75:0016.59Vascular2×MR3, MR7None
    10/67/FNo56:0034.6Vascular2×MR3, MR7None
    11/84/FNo135:008.47Vascular2×MR3, MR7None
    12/75/MNo56:3010.79Vascular2×MR3, MR7None
    13/74/FNo153:3013.88Vascular2×MR3, MR7, CTNone
    14/52/MNo105:0035.6Vascular2×MR3None
    15/77/MNo162:0012.92Vascular2×MR3, MR7, CTNone
    16/81/FNo173:0084.81Vascular1×MR3, MR7None
    17/78/FNo55:0016.52Vascular2×MR3, MR7None
    18/55/MNo216:0065.07Vascular2×MR3, MR7AH
    19/77/MNo76:302.3Vascular2×MR3, MR7AH
    20/46/FNo146:3012.41Vascular2×MR3, MR7None
    21/57/MNo167:0072.65Vascular2×MR3, MR7AH
    22/78/MNo203:3090.43Vascular2×MR3, MR7AH
    • * MR3 indicates MR imaging at day 3; MR7, MR imaging at day 7.

    • † Gadopentetate dimeglumine dose, 0.1 mmol/kg (= 1×) or 0.2 mmol/kg (= 2×).

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    TABLE 2:

    Relationship between the type of enhancement and age, baseline NIHSS, time to baseline MR study, or DWI volume

    MeasureEnhancementP Value
    Vascular (n = 19)Vascular and Parenchymal (n = 3)
    Age, y68.3 ± 10.765.0 ± 7.94.62
    Initial NIHSS score13.2 ± 5.212.3 ± 2.5.79
    Time to first MR study, h5.0 ± 1.44.2 ± 1.3.34
    Initial DWI volume, cm339.4 ± 33.136.5 ± 23.2.89
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American Journal of Neuroradiology: 24 (4)
American Journal of Neuroradiology
Vol. 24, Issue 4
1 Apr 2003
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Cite this article
Katie D. Vo, Fernando Santiago, Weili Lin, Chung Y. Hsu, Yueh Lee, Jin-Moo Lee
MR Imaging Enhancement Patterns as Predictors of Hemorrhagic Transformation in Acute Ischemic Stroke
American Journal of Neuroradiology Apr 2003, 24 (4) 674-679;

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MR Imaging Enhancement Patterns as Predictors of Hemorrhagic Transformation in Acute Ischemic Stroke
Katie D. Vo, Fernando Santiago, Weili Lin, Chung Y. Hsu, Yueh Lee, Jin-Moo Lee
American Journal of Neuroradiology Apr 2003, 24 (4) 674-679;
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  • What causes intracerebral bleeding after thrombolysis for acute ischaemic stroke? Recent insights into mechanisms and potential biomarkers
  • Effects of Microvascular Permeability Changes on Contrast-Enhanced T1 and Pharmacokinetic MR Imagings After Ischemia
  • Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke
  • Hemorrhagic Risk of Recent Silent Cerebral Infarct on Prethrombolysis MR Imaging in Acute Stroke
  • Impact of Baseline Tissue Status (Diffusion-Weighted Imaging Lesion) Versus Perfusion Status (Severity of Hypoperfusion) on Hemorrhagic Transformation
  • Early Disruption of the Blood-Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke
  • Vascular Permeability Precedes Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats
  • Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
  • Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
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