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EditorialEDITORIALS

Why Should Neuroradiologists Study Patients with Smell Loss?

Lucien M. Levy and Robert I. Henkin National Institutes of Neurological Diseases and Stroke
American Journal of Neuroradiology April 2003, 24 (4) 556-557;
Lucien M. Levy
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Robert I. Henkin
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References

  1. ↵
    Henkin RI. Report on a survey on smell in the US. Olfactory Review 1987;1:1–8
    PubMed
  2. ↵
    Henkin RI. Evaluation and treatment of human olfactory dysfunction. In: English GM, ed. Otolaryngology. Philadelphia: Lippincott;1993;2:1–86
  3. ↵
    Henkin RI. Drug-induced taste and smell disorders: incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction. Drug Saf 1994;11:318–377
  4. ↵
    Henkin RI. Sensory changes during the menstrual cycle. In: Ferrin M, Halberg F, Richart RM, Vandewiele RL, eds. Biorhythms and Human Reproduction. New York: Wiley;1974 :227–285
  5. ↵
    Mori S, Kaufmann WE, Davatzikos C, et al. Imaging cortical association tracts in the human brain using diffusion- tensor-based axonal tracking. Magn Reson Med 2002;47:215–223
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    Pautler RG, Silva AC, Koretsky AP. In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn Reson Med 1998;40:740–748
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    Pautler RG, Koretsky AP. Tracing odor-induced activation in the olfactory bulbs of mice using manganese-enhanced magnetic resonance imaging. Neuroimage 2002;16:441–448
  8. ↵
    Zald DH, Pardo JV. Emotion, olfaction, and the human amygdala: amygdala activation during aversive olfactory stimulation. Proc Natl Acad Sci U S A 1997;94:4119–4124
  9. ↵
    Levy LM, Hallett M. Impaired brain GABA in focal dystonia. Ann Neurol 2002;51:93–101
  10. ↵
    Levy LM, Henkin RI, Hutter A, Lin CS, Martins D, Schellinger D. Functional MRI of human olfaction. J Comput Assist Tomogr 1997;21:849–856
  11. ↵
    Koizuka I, Yano H, Nagahara M, et al. Functional imaging of the human olfactory cortex by magnetic resonance imaging. ORL J Otorhinolaryngol Relat Spec 1994;56:273–275
  12. Yousem DM, Maldjian JA, Siddiqi F, et al. Gender effects on odor-stimulated functional magnetic resonance imaging. Brain Res 1999;818:480–487
  13. Poellinger A, Thomas R, Lio P, et al. Activation and habituation in olfaction: an fMRI study. Neuroimage 2001;13:547–560
  14. Weismann M, Yousry I, Heuberger E, et al. Functional magnetic resonance imaging of human olfaction. Neuroimaging Clin N Am 2001;11:237–250, viii
  15. ↵
    Zald DH, Pardo JV. Functional neuroimaging of the olfactory system in humans. Int J Psychophysiol 2000;36:165–181
  16. ↵
    Levy LM, Henkin RI, Hutter A, Lin CS, Schellinger D. Mapping brain activation to odorants in patients with smell loss by functional MRI. J Comput Assist Tomogr 1998;22:96–103
  17. ↵
    Levy LM, Henkin RI, Lin CS, Finley A. Rapid imaging of olfaction by functional MRI (fMRI): identification of presence and type of hyposmia. J Comput Assist Tomogr 1999;23:767–775
  18. ↵
    Levy LM, Henkin RI, Lin CS, Hutter A, Schellinger D. Increased brain activation in response to odors in patients with hyposmia after theophylline treatment demonstrated by fMRI. J Comput Assist Tomogr 1998;22:760–770
  19. Levy LM, Henkin RI, Lin CS, Finley A, Schellinger D. Taste memory induces brain activation as revealed by functional MRI. J Comput Assist Tomogr 1999;23:499–505
  20. Levy LM, Henkin RI, Lin CS, Hutter A, Schellinger D. Odor memory induces brain activation as measured by functional MRI. J Comput Assist Tomogr 1999;23:487–498
  21. Levy LM, Henkin RI. Physiologically initiated and inhibited phantosmia: cyclic unirhinal, episodic, recurrent phantosmia revealed by brain fMRI. J Comput Assist Tomogr 2000;24:501–520
  22. Henkin RI, Levy LM, Lin CS. Taste and smell phantoms revealed by brain functional MRI (fMRI). J Comput Assist Tomogr 2000;24:106–123
  23. Henkin RI, Levy LM. Lateralization of brain activation to imagination and smell of odors using functional magnetic resonance imaging (fMRI): left hemispheric localization of pleasant and right hemispheric localization of unpleasant odors. J Comput Assist Tomogr 2001;25:493–514
  24. ↵
    Henkin RI, Levy LM. Functional MRI of congenital hyposmia: brain activation to odors and imagination of odors and tastes. J Comput Assist Tomogr 2002;26:39–61
  25. ↵
    Aguirre GK, Zarahn E, D’Esposito M. The variability of human, BOLD hemodynamic responses. Neuroimage 1998;8:360–369
  26. ↵
    Brett M, Johnsrude IS, Owen AM. The problem of functional localization in the human brain. Nat Rev Neurosci 2002;3:243–249
  27. ↵
    Suzuki Y, Critchley HD, Suckling J, et al. Functional magnetic resonance imaging of odor identification: the effect of aging. J Gerontol A Biol Sci Med Sci 2001;56:M756–60
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American Journal of Neuroradiology: 24 (4)
American Journal of Neuroradiology
Vol. 24, Issue 4
1 Apr 2003
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Lucien M. Levy, Robert I. Henkin
Why Should Neuroradiologists Study Patients with Smell Loss?
American Journal of Neuroradiology Apr 2003, 24 (4) 556-557;

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Why Should Neuroradiologists Study Patients with Smell Loss?
Lucien M. Levy, Robert I. Henkin
American Journal of Neuroradiology Apr 2003, 24 (4) 556-557;
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