Research ArticleSpine Imaging and Spine Image-Guided Interventions
Proton Magnetic Resonance Spectroscopy of the Thalamus in Patients with Chronic Neuropathic Pain after Spinal Cord Injury
Pradip M. Pattany, Robert P. Yezierski, Eva G. Widerström-Noga, Brian C. Bowen, Alberto. Martinez-Arizala, Bernardo R. Garcia and Robert M. Quencer
American Journal of Neuroradiology June 2002, 23 (6) 901-905;
Pradip M. Pattany
aDepartment of Radiology, University of Miami School of Medicine
Robert P. Yezierski
dDepartment of Orthodontics, University of Florida Gainesville, FL
Eva G. Widerström-Noga
bMiami Project to Cure Paralysis, University of Miami School of Medicine
Brian C. Bowen
aDepartment of Radiology, University of Miami School of Medicine
Alberto. Martinez-Arizala
cDepartment of Neurology, University of Miami School of Medicine
Bernardo R. Garcia
aDepartment of Radiology, University of Miami School of Medicine
Robert M. Quencer
aDepartment of Radiology, University of Miami School of Medicine

References
- ↵Störmer S, Gerner HJ, Gruninger W, et al. Chronic pain/dysaesthesiae in spinal cord injury patients: results of a multicentre study. Spinal Cord 1997;35:446–455
- Demirel G, Yllmaz H, Gencosmanoglu B, Kesiktas N. Pain following spinal cord injury. Spinal Cord 1998;36:25–28
- Rintala DH, Loubser PG, Castro J, Hart KA, Fuhrer MJ. Chronic pain in a community-based sample of men with spinal cord injury: prevalence, severity, and relationships with impairment, disability, handicap, and subjective well-being. Arch Phys Med Rehabil 1998;79:604–614
- ↵Siddall PJ, Taylor DA, McClelland JM, Rutkowski SB, Cousins MJ. Pain report and the relationship of pain to physical factors in the first 6 months following injury. Pain 1999;81:187–197
- Turner JA, Cardenas DD. Chronic pain problems in individuals with spinal cord injuries. Semin Clin Neuropsychiatry 1999;4:186–194
- ↵Turner JA, Cardenas DD, Warms CA, McClellan CB. Chronic pain associated with spinal cord injuries: a community survey. Arch Phys Med Rehabil 2001;82:501–509
- Finnerup NB, Johannesen IL, Sindrup SH, Bach FW, Jensen TS. Pain and dysesthesia in patients with spinal cord injury: a postal survey. Spinal Cord 2001;39:256–262
- ↵Widerström-Noga EG, Felipe-Cuervo E, Yezierski RP. Relationships among clinical characteristics of chronic pain following spinal cord injury. Arch Phys Rehab Med 2001;82:1191–1197
- ↵Vierck CJ, Siddall P, Yezierski, RP. Pain following spinal cord injury: animal models and mechanistic studies. Pain 2000;89:1–5
- ↵Siddall PJ, Loeser JD. Pain following spinal cord injury. Spinal Cord 2001;39:63–73
- ↵Bowsher D. Central pain: clinical and physiological characteristics. J Neurol Neurosurg, Psychiatry 1996;61:62–69
- ↵Eide PK. Pathophysiological mechanisms of central neuropathic pain after spinal cord injury. Spinal Cord 1998;36:601–612
- ↵Yezierski RP, Park SH. The mechanosensitivity of spinal sensory neurons following intraspinal injections of quisqualic acid in the rat. Neurosci Letters 1993;157:115–119
- Yezierski RP, Santana M, Park DH, Madsen PW. Neuronal degeneration and spinal cavitation following intraspinal injections of quisqualic acid in the rat. J Neurotrauma 1993;10:445–456
- Hao JX, Xu, XJ, Aldskogius H, Seiger Å, Wiesenfeld-Hallin Z. Chronic pain related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 1992;43:279–290
- ↵Christensen MD, Everhart AW, Pickeman J, Hulsebosch CE. Mechanical and thermal allodynia in chronic central pain following spinal cord injury. Pain 1996;68:97–107
- ↵Roberts MHT, Rees H. Denervation supersensitivity in the central nervous system: possible relation to central pain syndromes. In: KL Casey, ed. Pain and Central Nervous System Disease. New York, NY: Raven Press;1991 :219–321
- Loeser JD, Ward AA. Some effects of deafferentation on neurons of the cat spinal cord. Arch Neurol 1967;17:629–636
- ↵Loeser JD, Ward AA, White LE Jr. Chronic deafferentation of human spinal cord neurons. J Neurosurg 1968;29:48–50
- ↵Lenz FA, Tasker RR, Dostrovsky JO, et al. Abnormal single unit activity recorded in the somatosensory thalamus of a quadriplegic patient with central pain. Pain 1987;31:225–236
- ↵Ness TJ, San Pedro EC, Richards JS, Kezar L, Liu HG, Mountz JM. A case of spinal cord injury-pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentin. Pain 1998;78:139–143
- ↵Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Mag Reson Med 1993;30:672–679
- ↵Widerström-Noga EG, Cuervo E, Broton JG, Duncan RC, Yezierski RP. Perceived difficulty in dealing with consequences of spinal cord injury. Arch Phys Med and Rehab 1999;80:580–586
- ↵Yezierski RP. Pain following spinal cord injury: the clinical problem and experimental studies. Pain 1996;68:185–194
- ↵Nepomuceuno C, Fine PR, Richards JS, et al. Pain in patients with spinal cord injury. Arch Phys Med Rehab 1979;60:605–609
- ↵Iadecola C. Regulation of cerebral microcirculation during neural activity: is nitric oxide the missing link. TINS 1993;16:206–214
- ↵Bowen BC, Block RE, Sanchez-Ramos J, et al. Proton MR spectroscopy of the brain of 14 patients with Parkinson’s disease. AJNR Am J Neuroradiol 1995;16:61–68
- ↵Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2000;21:647–658
- ↵Castillo M, Kwock L, Mukherji SK. Clinical applications of proton MR spectroscopy. AJNR Am J Neuroradiol 1996;17:1–15
- ↵Isaacks RE, Bender AS, Kim CY, Prieto NM, Norenberg MD. Osmotic regulation of myo-inositol uptake in primary astrocyte cultures. Neurochem Res 1994;19:331–338
- ↵Huppi PS, Lazeyras F, Burri R, Bossi E, Herschkowitz N. Magnetic resonance in preterm and term newborns: 1H-spectroscopy in developing brain. Pediatr Res 1991;30:574–578
- Kimura FH, Fujii Y, Itoh S, et al. Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy. Radiology 1995;194:483–489
- ↵Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Mag Reson Med 1993;30:424–437
- ↵Pouwels PJ, Brockmann K, Kruse B, et al. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999;46:474–485
- ↵
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Pradip M. Pattany, Robert P. Yezierski, Eva G. Widerström-Noga, Brian C. Bowen, Alberto. Martinez-Arizala, Bernardo R. Garcia, Robert M. Quencer
Proton Magnetic Resonance Spectroscopy of the Thalamus in Patients with Chronic Neuropathic Pain after Spinal Cord Injury
American Journal of Neuroradiology Jun 2002, 23 (6) 901-905;
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Proton Magnetic Resonance Spectroscopy of the Thalamus in Patients with Chronic Neuropathic Pain after Spinal Cord Injury
Pradip M. Pattany, Robert P. Yezierski, Eva G. Widerström-Noga, Brian C. Bowen, Alberto. Martinez-Arizala, Bernardo R. Garcia, Robert M. Quencer
American Journal of Neuroradiology Jun 2002, 23 (6) 901-905;
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