Research ArticleBrain
Diffusion and Perfusion MR Imaging in Cases of Alzheimer's Disease: Correlations with Cortical Atrophy and Lesion Load
Alessandro Bozzao, Roberto Floris, Maria Elena Baviera, Alessio Apruzzese and Giovanni Simonetti
American Journal of Neuroradiology June 2001, 22 (6) 1030-1036;
Alessandro Bozzao
Roberto Floris
Maria Elena Baviera
Alessio Apruzzese

References
- ↵Smith GS, de Leon MJ, George AE, et al. Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's disease: pathophysiologic implications. Arch Neurol 1992;49:1142-1150
- Mielke R, Herholz K, Grond M, Kessler J, Heiss WD. Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas. Dementia 1994;5:36-41
- Fazekas F, Alavi A, Chawluk JB, et al. Comparison of CT, MR and PET in Alzheimer's dementia and normal aging. J Nucl Med 1989;30:1607-1615
- ↵Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A. The scintigraphic appearance of Alzheimer's disease: a prospective study using technetium-99m-HMPAO SPECT. J Nucl Med 1992;33:181-185
- Reed BR, Jagust WJ, Sacb JP, Ober BA. Memory and regional cerebral blood flow in mildly symptomatic Alzheimer's disease. Neurology 1989;39:1537-1539
- Pearlson GD, Harris GJ, Powers RE, et al. Quantitative changes in mesial temporal volume, regional cerebral blood flow, and cognition in Alzheimer's disease. Arch Gen Psychiatry 1992;49:402-408
- Harris GJ, Links JM, Pearlson GD, Camargo EE. Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. Psychiatry Res 1991;40:167-180
- ↵Harris GJ, Lewis RF, Satlin A, et al. Dynamic susceptibility contrast MRI of regional cerebral blood volume in Alzheimer disease: a promising alternative to nuclear medicine. AJNR Am J Neuroradiol 1998;19:1727-1732
- ↵Sandson TA, Felician O, Edelman RR, Warach S. Diffusion-weighted magnetic resonance imaging in Alzheimer's disease. Dement Geriatr Cogn Disord 1999;10:166-171
- ↵Hanyu H, Sakurai H, Iwamoto T, Takesaki M, Shindo H, Abe K. Diffusion weighted MR imaging of the hippocampus and temporal white matter in Alzheimer disease. J Neurol Sci 1998;156:195-200
- ↵Flacke S, Keller E, Hartman A, et al. Improved diagnosis of early infarcts by the combined use of perfusion and diffusion-weighted imaging. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1998;168:493-501
- ↵Pickut BA, Dierckx RA, Dobbeleir A, et al. Validation of the cerebellum as a reference region for SPECT quantification in patients suffering from dementia of the Alzheimer type. Psychiatry Res 1999;90:103-112
- ↵Hyman BT, Damasio H, Damasio AR, Van Hoessen GW. Alzheimer's disease. Annu Rev Public Health 1989;10:115-140
- Perl DP, Pendlebury WW. Neuropathology of Alzheimer's disease and related dementias. In: Meltzer HY, ed. Psychopharmacology: A Third Generation of Progress. New York: Raven Press; 1987
- Risse SC, Raskind MA, Nochlin D, et al. Neuropathological findings in patients with clinical diagnoses of probable Alzheimer's disease. Am J Psychiatry 1990;147:168-172
- Brun A. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and hystopathological grading. Hystopathology 1981;5:549-564
- ↵Fox NC, Sacra RI, Crumb WR, Rosier MN. Correlation between rates of brain atrophy and cognitive decline in AD. Neurology 1999;52:1687-1689
- ↵Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJNR Am J Neuroradiol 1987;149:351-356
- ↵Bowen BC, Barker WW, Loewenstein DA, Sheldon A, Duara R. MR signal abnormalities in memory disorder and dementia. AJNR Am J Neuroradiol 1990;11:283-290
- ↵Wolfe N, Bruce R, et al. Temporal lobe perfusion on single photon emission computed tomography predicts the rate of cognitive decline in Alzheimer's disease. Arch Neurol 1995;52:257-262
- Johnson KA, Kijewski MF, Becker JA, Garada B, Satlin A, Holman BL. Quantitative brain SPECT in Alzheimer's disease and normal aging. J Nucl Med 1993;34:2044-2048
- O'Mahony D, Coffey J, Murphy J, et al. The discriminant value of semiquantitative SPECT data in mild Alzheimer's disease. J Nucl Med 1994;35:1450-1455
- ↵Tanna N, Kohn M, Horwuch D, et al. Analysis of brain and cerebrospinal fluid volumes with MR imaging: part II. aging and Alzheimer dementia. Radiology 1991;178:123-130
- Jack CR, Petersen RC, O'Brien PC, et al. MR- base hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology 1992;42:183-188
- ↵Rusinek H, de Leon MJ, George AE, et al. Alzheimer's disease: measuring loss of cerebral gray matter with MR imaging. Radiology 1991;178:109-114
- ↵Tanabe JL, Amend D, Schuff N, et al. Tissue segmentation of the brain in Alzheimer disease. AJNR Am J Neuroradiol 1997;18:115-123
- ↵Meltzer CC, Zubieta JK, Brandt J, Tune LE, Mayberg HS, Frost JJ. Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging. Neurology 1996;47:454-461
- ↵Jernigan TL, Salmon DP, Butters N, Hesselink JR. Cerebral structure on MRI: part II. specific changes in Alzheimer's and Huntington's diseases. Biol Psychiatry 1991;29:68-81
- Schmidt R. Comparison of magnetic resonance imaging in Alzheimer's disease, vascular dementia and normal aging. Eur Neurol 1992;32:164-169
- McDonald WM, Krishnan KR, Doraiswamy PM, et al. Magnetic resonance findings in patients with early-onset Alzheimer's disease. Biol Psychiatry 1991;29:699-710
- ↵Waldemar G, Christiansen P, Larsson HB, et al. White matter magnetic resonance hyperintensities in dementia of the Alzheimer type: morphological and regional cerebral blood flow correlates. J Neurol Neurosurg Psychiatry 1994;57:1458-1465
- ↵Brun A, Englund EA. White matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 1986;19:253-262
- Leys D, Soetaert G, Petit H, Fauquette A, Pruvo JP, Steinling M. Periventricular and white matter MRI hyperintensities do not differ between Alzheimer's disease and normal aging. Arch Neurol 1990;47:524-527
- ↵Wahlund LO, Basun H, Almkvist O, Andersson-Lundman G, Julin P, Saaf J. White matter hyperintensities in dementia: does it matter? Magn Reson Imaging 1994;3:387-394
- Bennett DA, Gilley DS, Wilson RS, Huckman MS, Fox JH. Clinical correlates of high signal lesions on magnetic resonance imaging in Alzheimer's disease. J Neurol 1992;239:186-190
- ↵Mark RJ, Hedlund LW, Butterfield DA, Mattson MP. Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. J Neurosci 1995;15:6239-6249
- Terry RD. The pathogenesis of Alzheimer disease: an alternative to amyloid hypothesis. J Neuropathol Exp Neurol 1996;55:1023-1025
- Pappella MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative stress in Alzheimer disease. Am J Pathol 1992;140:621-628
In this issue
Advertisement
Alessandro Bozzao, Roberto Floris, Maria Elena Baviera, Alessio Apruzzese, Giovanni Simonetti
Diffusion and Perfusion MR Imaging in Cases of Alzheimer's Disease: Correlations with Cortical Atrophy and Lesion Load
American Journal of Neuroradiology Jun 2001, 22 (6) 1030-1036;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
- Multi-scale Assessment of Brain Blood Volume and Perfusion in the APP/PS1 Mouse Model of Amyloidosis
- Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease
- A review of structural magnetic resonance neuroimaging
- From The Cover: Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
- White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement