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Research ArticleBRAIN

Comparative Analysis of MR Imaging, Positron Emission Tomography, and Ictal Single-photon Emission CT in Patients with Neocortical Epilepsy

Sung-Il Hwang, Jae Hyoung Kim, Sun Won Park, Moon Hee Han, In Kyu Yu, Sang Hyun Lee, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung and Kee-Hyun Chang
American Journal of Neuroradiology May 2001, 22 (5) 937-946;
Sung-Il Hwang
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Jae Hyoung Kim
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Sun Won Park
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Moon Hee Han
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In Kyu Yu
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Sang Hyun Lee
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Dong Soo Lee
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Sang Kun Lee
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Chun-Kee Chung
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Kee-Hyun Chang
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    fig 1.

    Concordance of the results among MR imaging, PET, and ictal SPECT findings for a 36-year-old man with left neocortical temporal lobe epilepsy.

    A, Oblique coronal fast spin-echo T2-weighted (6000/90) MR image shows a well-defined focal high signal intensity in the left inferior temporal lobe (arrow).

    B, FDG PET scan shows hypometabolism in the left inferior temporal lobe (arrow).

    C, Ictal SPECT scan shows focal hyperperfusion in the left inferior temporal lobe (arrow). Lesion-like increased uptake in the right frontotemporal lobe is due to asymmetrical reconstruction of the image. After anterior temporal lobectomy, the pathologic diagnosis was dysembryoplastic neuroepithelial tumor. Engel's outcome was class I

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    fig 2.

    False-negative MR imaging finding for a 24-year-old woman with left frontal lobe epilepsy.

    A, Axial fast spin-echo T2-weighted (5000/100) MR image shows no diagnostic abnormality.

    B, FDG PET scan shows diffuse hypometabolism in the left frontal and parietal cortices (arrows).

    C, Ictal SPECT scan shows diffuse hyperperfusion in the same area as that shown in B (arrows). Invasive EEG study localized the epileptogenic focus in the left inferior frontal lobe. After neocortical resection, the pathologic diagnosis was cortical dysplasia. Engel's outcome was class I

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    fig 3.

    False-negative MR imaging and ictal SPECT findings for an 18-year-old female patient with left frontal lobe epilepsy.

    A, Axial fast spin-echo T2-weighted (6000/90) MR image shows no diagnostic abnormality.

    B, FDG PET scan shows focal hypometabolism in the left frontal cortex (arrows).

    C, Ictal SPECT scan fails to show hyperperfusion in any area. Lesion-like increased uptake in the left basal ganglia is due to asymmetrical reconstruction of the image. Invasive EEG study detected ictal activity originating from the left frontal lobe. After neocortical resection, the pathologic diagnosis was microdysgenesis. Engel's outcome was class IV

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    fig 4.

    False-negative MR imaging and PET findings for a 25-year-old woman with right neocortical temporal lobe epilepsy.

    A, Axial fast spin-echo T2-weighted (6000/90) MR image shows no focal abnormalities.

    B, Axial FDG PET scan show no focal abnormalities.

    C, Ictal SPECT scan shows somewhat diffuse hyperperfusion in the right frontotemporal cortices (arrows). Invasive EEG study detected ictal activity arising from the right temporoparietal area. After neocortical resection, the pathologic diagnosis was heterotopia. Engel's outcome was class I

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    TABLE 1:

    Pathologic diagnosis of neocortical epilepsy

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    TABLE 2:

    Correct localization rates of imaging methods

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    TABLE 3:

    Concordance rates among three imaging methods

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    TABLE 4:

    Correct localization rates of imaging methods in patients with good surgical outcomes

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    TABLE 5:

    Correct localization rates of PET and ictal SPECT in patients with normal MR imaging findings

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    TABLE 6:

    Surgical outcomes according to MR imaging abnormality

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American Journal of Neuroradiology
Vol. 22, Issue 5
1 May 2001
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Cite this article
Sung-Il Hwang, Jae Hyoung Kim, Sun Won Park, Moon Hee Han, In Kyu Yu, Sang Hyun Lee, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung, Kee-Hyun Chang
Comparative Analysis of MR Imaging, Positron Emission Tomography, and Ictal Single-photon Emission CT in Patients with Neocortical Epilepsy
American Journal of Neuroradiology May 2001, 22 (5) 937-946;

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Comparative Analysis of MR Imaging, Positron Emission Tomography, and Ictal Single-photon Emission CT in Patients with Neocortical Epilepsy
Sung-Il Hwang, Jae Hyoung Kim, Sun Won Park, Moon Hee Han, In Kyu Yu, Sang Hyun Lee, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung, Kee-Hyun Chang
American Journal of Neuroradiology May 2001, 22 (5) 937-946;
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  • Statistical SPECT processing in MRI-negative epilepsy surgery
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  • Differential Features of Metabolic Abnormalities Between Medial and Lateral Temporal Lobe Epilepsy: Quantitative Analysis of 18F-FDG PET Using SPM
  • Correlation Between PET and SISCOM in Temporal Lobe Epilepsy
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