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Research ArticleBRAIN

MDMA (“Ecstasy”) and Its Association with Cerebrovascular Accidents: Preliminary Findings

Liesbeth Reneman, Jan B. A. Habraken, Charles B. L. Majoie, Jan Booij and Gerard J. den Heeten
American Journal of Neuroradiology June 2000, 21 (6) 1001-1007;
Liesbeth Reneman
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Jan B. A. Habraken
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Charles B. L. Majoie
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Jan Booij
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Gerard J. den Heeten
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    fig 1.

    The mean and individual [123I]R91150 binding ratios in the cortex: control subjects versus MDMA and ex-MDMA users. Cortical binding ratios were calculated as cortical binding / binding in the cerebellum. Asterisk indicates a statistically significant difference in binding ratio as compared with control subjects and ex-MDMA users

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    fig 2.

    [123I]R91150 SPECT images in a control subject, a recent MDMA user, and an ex-MDMA user. Transverse slices from the brain at the level of the basal ganglia, approximately 3 cm above the orbitomeatal line. In the three images, the level of [123I]R91150 activity is color-coded from low (black) to high (white) and scaled to the maximum in the slice obtained in the control subject. The three images are representative of the three groups: in the control subject, there is normal [123I]R91150 binding, in the recent MDMA user, low [123I]R91150 binding, and in the ex-MDMA user, high [123I]R91150 binding

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    fig 3.

    Higher rCBV values are observed in the left globus pallidus and right thalamus in the ex-MDMA users than in the control subjects. After registration in the same orientation (in six control subjects and two ex-MDMA users), an unpaired Student's t-test was performed on each voxel of generated rCBV maps, revealing significant differences in the colored regions (yellow, P < .025; red, P < .005). Images were obtained at intervals of 1202 milliseconds (800/54) before, during, and after injection of contrast agent

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    fig 4.

    A–D, Cortical [123I]R91150 binding versus rCBV values in specific brain regions. Open square, control subjects; solid square, MDMA users. Each symbol represents an individual subject

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    TABLE 1:

    5-HT2 receptor imaging: characteristics of participants and mean cortical [123I]R91150 binding ratios*

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    TABLE 2:

    rCBV values: characteristics of participants and mean rCBV ratio in brain areas studied*

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American Journal of Neuroradiology
Vol. 21, Issue 6
1 Jun 2000
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Cite this article
Liesbeth Reneman, Jan B. A. Habraken, Charles B. L. Majoie, Jan Booij, Gerard J. den Heeten
MDMA (“Ecstasy”) and Its Association with Cerebrovascular Accidents: Preliminary Findings
American Journal of Neuroradiology Jun 2000, 21 (6) 1001-1007;

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MDMA (“Ecstasy”) and Its Association with Cerebrovascular Accidents: Preliminary Findings
Liesbeth Reneman, Jan B. A. Habraken, Charles B. L. Majoie, Jan Booij, Gerard J. den Heeten
American Journal of Neuroradiology Jun 2000, 21 (6) 1001-1007;
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