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Research ArticleHead and Neck Imaging

Imaging of Nonlaryngeal Neuroendocrine Carcinoma

Uday S. Kanamalla, Prabhakar P. Kesava and H. Stan McGuff
American Journal of Neuroradiology April 2000, 21 (4) 775-778;
Uday S. Kanamalla
aFrom the Section of Neuroradiology (U.S.K., P.P.K.) and Department of Pathology (H.S.M.), University of Texas Health Science Center, San Antonio, TX.
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Prabhakar P. Kesava
aFrom the Section of Neuroradiology (U.S.K., P.P.K.) and Department of Pathology (H.S.M.), University of Texas Health Science Center, San Antonio, TX.
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H. Stan McGuff
aFrom the Section of Neuroradiology (U.S.K., P.P.K.) and Department of Pathology (H.S.M.), University of Texas Health Science Center, San Antonio, TX.
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    fig 1.

    Case 1. A, Axial unenhanced CT scan shows a soft-tissue density mass in the sphenoid sinus. The mass is seen to expand the sinus.

    B, Sagittal T1-weighted MR image (600/16/1 [TR/TE/excitations]) shows the nasopharyngeal component of the sphenoid mass. Note that the floor of the sella appears intact.

    C, Coronal contrast-enhanced T1-weighted MR image (433/17/1) shows mild heterogeneous enhancement of the sphenoid sinus mass.

    D, Axial fast spin-echo T2-weighted MR image (3250/95/3) shows the sphenoid sinus mass to be heterogeneously hyperintense.

    E, Neuroendocrine carcinoma of the sphenoid sinus consisting of small pleomorphic cells exhibiting crowded hyperchromatic nuclei (hematoxylin and eosin stain; original magnification, ×40).

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    fig 2.

    Case 2. A, Axial unenhanced CT scan shows a large expansile maxillary sinus mass with extension into the nasal cavity, the nasopharynx, the infratemporal fossa, and the subcutaneous tissues of the left maxillary region.

    B, Coronal unenhanced CT scan shows a large expansile mass in the left maxillary sinus that erodes the sinus walls and extends into the nasal cavity, left orbit, and subcutaneous soft tissues of the maxillary region.

    C, Poorly differentiated neuroendocrine carcinoma infiltrating maxillary bone. The tumor consists of small pleomorphic spindled cells with hyperchromatic nuclei. Focal rosette formation is noted (hematoxylin and eosin stain; original magnification, ×10).

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    fig 3.

    Case 3. A, Axial contrast-enhanced CT scan shows a mildly enhancing circumscribed mass (arrow) in the lateral aspect of the superficial lobe of the right parotid gland.

    B, Metastatic poorly differentiated neuroendocrine carcinoma to an intraparotid lymph node. The tumor cells display pleomorphic vesicular nuclei with finely dispersed chromatin, scant cytoplasm, and a high mitotic rate (hematoxylin and eosin stain; original magnification, ×40).

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American Journal of Neuroradiology
Vol. 21, Issue 4
1 Apr 2000
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Cite this article
Uday S. Kanamalla, Prabhakar P. Kesava, H. Stan McGuff
Imaging of Nonlaryngeal Neuroendocrine Carcinoma
American Journal of Neuroradiology Apr 2000, 21 (4) 775-778;

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Imaging of Nonlaryngeal Neuroendocrine Carcinoma
Uday S. Kanamalla, Prabhakar P. Kesava, H. Stan McGuff
American Journal of Neuroradiology Apr 2000, 21 (4) 775-778;
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