Research ArticleBRAIN
Pituitary Hypoplasia in Patients with a Mutation in the Growth hormone–releasing Hormone Receptor Gene
Robert A. Murray, Hiralal G. Maheshwari, Eric J. Russell and Gerhard Baumann
American Journal of Neuroradiology April 2000, 21 (4) 685-689;
Robert A. Murray
aFrom the Departments of Radiology (R.A.M., E.J.R.) and Medicine (H.G.M., G.B.) and the General Clinical Research Center, Northwestern University Medical School, Chicago, IL.
Hiralal G. Maheshwari
aFrom the Departments of Radiology (R.A.M., E.J.R.) and Medicine (H.G.M., G.B.) and the General Clinical Research Center, Northwestern University Medical School, Chicago, IL.
Eric J. Russell
aFrom the Departments of Radiology (R.A.M., E.J.R.) and Medicine (H.G.M., G.B.) and the General Clinical Research Center, Northwestern University Medical School, Chicago, IL.
Gerhard Baumann
aFrom the Departments of Radiology (R.A.M., E.J.R.) and Medicine (H.G.M., G.B.) and the General Clinical Research Center, Northwestern University Medical School, Chicago, IL.

References
- ↵Kelly WM, Kucharczyk W, Kucharczyk J, et al. Posterior pituitary ectopia: an MR feature of pituitary dwarfism. AJNR Am J Neuroradiol 1988;9:453-460
- ↵Koroiwa T, Okabe Y, Hasuo K, Yasumori K, Mizushima A, Masuda K. MR imaging of pituitary dwarfism. AJNR Am J Neuroradiol 1991;12:161-164
- ↵Pellini C, diNatale B, De Angelis R, et al. Growth hormone deficiency in children: role of magnetic resonance imaging in assessing aetiopathogenesis and prognosis in idiopathic hypopituitarism. Eur J Pediatr 1990;149:536-541
- Arygropoulo M, Perignon F, Brauner R, Brunelle F. Magnetic resonance imaging in the diagnosis of growth hormone deficiency. J Pediatr 1992;120:886-891
- Elster AD. Modern imaging of the pituitary. Radiology 1993;184:1-14
- Zucchini S, di Natale B, Ambrosetto P, De Angelis R, Cacciari E, Chiumello G. Role of magnetic resonance imaging in hypothalamic-pituitary disorders. Horm Res 1995;44[suppl]:8-14
- ↵Treier M, Gleiberman AS, O'Connell SM, et al. Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 1998;12:1691-1704
- Parks JS, Adess ME, Brown MR. Genes regulating hypothalamic and pituitary development. Acta Paediatr Suppl 1997;423:28-32
- ↵Sornson MW, Wu W, Dasen JS, et al. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 1996;384:327-333
- Li S, Crenshaw EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain pit-1. Nature 1990;347:528-533
- ↵Godfrey P, Rahal JO, Beamer WG, Copeland NG, Jenkins NA, Mayo K. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 1993;4:227-232
- ↵Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 1993;364:208-213
- ↵Wilson DB, Wyatt DP, Gadler RM, Baker CA. Quantitative aspects of growth hormone cell maturation in the normal and little mutant mouse. Acta Anat (Basel) 1988;131:150-155
- ↵Billestrup N, Swanson LW, Vale W. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci U S A 1986;83:6854-6857
- ↵Wajnrajch MP, Gertner JM, Harbison MD, Chua SC Jr, Leibel RL. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nat Genet 1996;12:88-90
- ↵Baumann G, Maheshwari H. The dwarfs of Sindh: severe growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. Acta Paediatr Suppl 1997;423:33-38
- ↵Maheshwari HG, Silverman BL, Dupuis J, Baumann G. Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone releasing hormone receptor: dwarfism of Sindh. J Clin Endocrinol Metab 1998;83:4065-4074
- ↵Di Chiro G, Nelson KB. The volume of the sella turcica. AJR Am J Roentgenol 1962;87:989-1008
- ↵Tsunoda A, Okuda O, Sato K. MR height of the pituitary gland as a function of age and sex: especially physiological hypertrophy in adolescence and in climacterium. AJNR Am J Neuroradiol 1997;18:551-554
- Wiener SN, Rzeszotarski MS, Droege RT, Pearlstein AE, Shafron M. Measurement of pituitary gland height with MR imaging. AJNR Am J Neuroradiol 1985;6:717-722
- ↵Doraiswamy PM, Potts JM, Axelson DA, et al. MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences. AJNR Am J Neuroradiol 1992;13:1295-1299
- Lurie SN, Doraiswamy PM, Husain MM, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. J Clin Endocrinol Metab 1990;71:505-508
- McLachlan MSF, Williams ED, Fortt RW, Doyle FH. Estimation of pituitary gland dimensions from radiographs of the sella turcica. Br J Radiol 1968;41:323-330
- Eicher EM, Beamer WG. Inherited ateliotic dwarfism in mice: characteristics of the mutation, little, on chromosome 6. J Hered 1976;67:87-91
- ↵Thorner MO, Vance ML, Laws ER, Horvath E, Kovacs K. The anterior pituitary. In Wilson JD, Foster D, Kronenberg HM, Larsen PR, eds. Williams' Textbook of Endocrinology. 9th ed, Philadelphia: WB Saunders; 1998: 249-340
- ↵Netchine I, Talon P, Dastot F, Vitaux F, Goossens M, Amselem S. Extensive phenotypic analysis of a family with growth hormone deficiency caused by a mutation in the GH-releasing hormone receptor gene. J Clin Endocrinol Metab 1998;83:432-436
- ↵Wilson D, Wyatt DP. Immunofluorescent analysis of somatotroph distribution in the adenohypophysis of developing lit/lit mice. J Anat 1988;156:51-59
- Smith SP, Wolpert SM, Sadeghi-Nejad A, Senior B. Value of computed tomographic scanning in patients with growth hormone deficiency. Pediatrics 1986;78:601-605
- ↵Marwaha R, Menon PSN, Jena A, Pant C, Sethi AK, Sapra ML. Hypothalamo-pituitary axis by magnetic resonance imaging in isolated growth hormone deficiency patients born by normal delivery. J Clin Endocrinol Metab 1992;74:654-659
- ↵Dattani MT, Martinez-Barbera JP, Thomas PQ, et al. Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet 1998;19:125-133
- ↵Arrigo T, De Luca F, Maghnie M, et al. Relationships between neuroradiological and clinical features in apparently idiopathic hypopituitarism. Eur J Endocrinol 1998;139:84-88
- ↵Kornreich L, Horev G, Lazar L, Schwarz M, Sulkes J, Pertzelan A. MR findings in growth hormone deficiency: correlation with severity of hypopituitarism. AJNR Am J Neuroradiol 1998;19:1495-1499
- ↵Nagel BHP, Palmbach M, Petersen D, Ranke MB. Magnetic resonance images of 91 children with different causes of short stature: pituitary size reflects growth hormone secretion. Eur J Pediatr 1997;156:758-769
- ↵
- ↵
In this issue
Advertisement
Robert A. Murray, Hiralal G. Maheshwari, Eric J. Russell, Gerhard Baumann
Pituitary Hypoplasia in Patients with a Mutation in the Growth hormone–releasing Hormone Receptor Gene
American Journal of Neuroradiology Apr 2000, 21 (4) 685-689;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement