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Research ArticleBRAIN

Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype

Erin D. Bigler, Christopher M. Lowry, Carol V. Anderson, Sterling C. Johnson, John Terry and Marc Steed
American Journal of Neuroradiology November 2000, 21 (10) 1857-1868;
Erin D. Bigler
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Christopher M. Lowry
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Carol V. Anderson
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Sterling C. Johnson
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John Terry
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Marc Steed
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    fig 1.

    A–C, Graphic depictions of mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) for ϵ4+ and ϵ4− subjects for each diagnostic classification: control group, Alzheimer disease (AD), mild ambiguous (M/A), vascular dementia (VaD), cerebrovascular disease (CVA), frontal lobe dementia (FLA), Parkinson's disease (Parkinson), psychiatric disorder (Psych), dementia unknown (Dem Unk), alcoholism (ETOH), and amnesic disorder (Mem Amn). The first numeric value represents the total number of ϵ4− subjects, with the second numeric value indicating sample size of the ϵ4+ subjects

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    fig 2.

    A–C, Scatter plots for subjects with AD and combined MCI and VaD by age for brain volume (A), hippocampal volume (B), and VBR (C) based on the following correlations: Brain volume, rϵ4− = −.26, P ≤ .01; rϵ4+ = −0.19, P ≤ .01; hippocampal volume, rϵ4− = 0.17, P ≤ .05; rϵ4+ = 0.01, P > .05; and VBR, rϵ4− = −.34, P ≤ .01; rϵ4+ = 0.13, P ≤ .05

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    fig 3.

    A–C, Mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) by length of disease (LOD) in years

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    fig 4.

    A–C, Mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) for 3MS performance, which has been segregated into three levels: normal (> 91), mild to moderate impairment (71–90), and moderate to severe impairment (<70). Correlation values (Spearman rank) for each brain measure by 3MS performance level are shown in the boxes

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    Study demographics

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    Quantitative MR findings in brain parenchyma

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    TABLE 3:

    Brain CSF quantitative MR findings

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American Journal of Neuroradiology
Vol. 21, Issue 10
1 Nov 2000
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Cite this article
Erin D. Bigler, Christopher M. Lowry, Carol V. Anderson, Sterling C. Johnson, John Terry, Marc Steed
Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
American Journal of Neuroradiology Nov 2000, 21 (10) 1857-1868;

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Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
Erin D. Bigler, Christopher M. Lowry, Carol V. Anderson, Sterling C. Johnson, John Terry, Marc Steed
American Journal of Neuroradiology Nov 2000, 21 (10) 1857-1868;
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