Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy

Yonglin Pu, Qing-Feng Li, Chao-Mei Zeng, Jian Gao, Jing Qi, De-Xin Luo, Srikanth Mahankali, Peter T. Fox and Jia-Hong Gao
American Journal of Neuroradiology January 2000, 21 (1) 203-212;
Yonglin Pu
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qing-Feng Li
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chao-Mei Zeng
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jian Gao
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jing Qi
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
De-Xin Luo
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Srikanth Mahankali
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter T. Fox
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jia-Hong Gao
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Rivkin MJ. Hypoxic-ischemic brain injury in the term newborn: neuropathology, clinical aspects and neuroimaging. Clin Perinatol 1997;24:607-625
    PubMedWeb of Science
  2. ↵
    Cotman CW, Iversen LL. Excitatory amino acids in the brain: focus on NMDA receptors. Trends Neurosci 1987;10:263-265
    CrossRefWeb of Science
  3. ↵
    Cataltepe O, Towfighi J, Vannucci RC. Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. Brain Res 1996;709:326-330
    CrossRefPubMed
  4. ↵
    Ottersen OP, Laake JH, Reichelt W, Haug FM, Torp R. Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses. J Chem Neuroanat 1996;12:1-14
    CrossRefPubMedWeb of Science
  5. ↵
    Erecinska M, Silver IA. Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 1990;35:245-296
    CrossRefPubMedWeb of Science
  6. Philis JW, O'Regan MH. Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Res 1996;730:150-164
    CrossRefPubMedWeb of Science
  7. Kanthan R, Shuaib A, Griebel R, Miyashita H. Intracerebral human microdialysis: in vivo study of acute focal ischemic model of the human brain. Stroke 1995;26:870-873
    Abstract/FREE Full Text
  8. Hajek M, Do KQ, Boesiger P, Wieser HG. Increased excitatory amino acid levels in brain cysts of epileptic patients. Epilepsy Res 1997;28:245-254
    CrossRefPubMed
  9. Podell M, Hadjiconstantinou M. Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy. Am J Vet Res 1997;58:451-456
    PubMedWeb of Science
  10. ↵
    Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic/ischemic brain damage. Ann Neurol 1986;19:105-111
    CrossRefPubMedWeb of Science
  11. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci 1987;10:299-302
    CrossRefWeb of Science
  12. Choi D. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc Brain Metab Rev 1990;2:105-147
    PubMedWeb of Science
  13. ↵
    du Plessis AJ, Johnston MV. Hypoxic-ischemic brain injury in the newborn, cellular mechanisms and potential strategies for neuroprotection. Clin Perinatol 1997;24:627-654
    PubMedWeb of Science
  14. ↵
    Mason GF, Pan JW, Ponder SL, Twieg DB, Pohost GM, Hetherington HP. Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T. Magn Reson Med 1994;32:142-145
    PubMed
  15. ↵
    McConnell JR, Antonson DL, Ong CS, et al. Proton spectroscopy of brain glutamine in acute liver failure. Hepatology 1995;22:69-74
    CrossRefPubMedWeb of Science
  16. ↵
    Ross B, Michaelis T. Clinical application of magnetic resonance spectroscopy. Magn Reson Q 1994;10:191-247
    PubMedWeb of Science
  17. Bachelard H, Badar-Goffer R. NMR spectroscopy in neurochemistry. J Neurochem 1993;61:412-429
    PubMedWeb of Science
  18. ↵
    Rothman DL, Hanstock CC, Petroff OAC, Novotny EJ, Prichard JW, Shulman RG. Localized 1H MRS spectra of glutamate in human brain. Magn Reson Med 1992;25:94-106
    CrossRefPubMed
  19. ↵
    Connelly A, Cross JH, Gadian DG, Hunter JV, Kirkham FJ, Leonard JV. Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency. Pediatr Res 1993;33:77-81
    PubMedWeb of Science
  20. ↵
    Kauppinen RA, Williams SR. Nondestructive detection of glutamate by 1H nuclear magnetic resonance spectroscopy in cortical brain slices from the guinea pig: evidence for changes in detectability during severe anoxic insults. J Neurochem 1991;57:1136-1144
    CrossRefPubMed
  21. Kauppinen RA, Pirttila TRM, Auriola SOK, Williams SR. Compartmentation of cerebral glutamate in situ as detected by 1H and 13C n.m.r. Biochem J 1994;298:121-127
    Abstract/FREE Full Text
  22. ↵
    Kreis R, Arcinue E, Ernst T, Shonk TK, Flores R, Ross BD. Hypoxic encephalopathy after near-drowning studied by quantitative 1H-magnetic resonance spectroscopy: metabolic changes and their prognostic value. J Clin Invest 1996;97:1142-1154
    CrossRefPubMedWeb of Science
  23. ↵
    Huppi PS, Barnes PD. Magnetic resonance techniques in the evaluation of newborn brain. Clin Perinatol 1997;24:693-723
    PubMed
  24. Penrice J, Cady EB, Lorek A, et al. Proton magnetic resonance spectroscopy of brain in normal preterm and term infants, and early changes following perinatal hypoxia-ischemia. Pediatr Res 1996;40:6-14
    CrossRefPubMedWeb of Science
  25. Groenendaal F, Veenhoven RH, Van Der Grond J, Jansen GH, Witkamp TD, De Vries LS. Cerebral lactate and N-acetyl-aspartate/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Pediatr Res 1994;35:148-151
    CrossRefPubMedWeb of Science
  26. Peden CJ, Rutherford MA, Sargentoni J, Cox IJ, Bryant DJ, Dubowitz LMS. Proton spectroscopy of the neonatal brain following hypoxic-ischemic injury. Dev Med Child Neurol 1993;35:502-510
    PubMedWeb of Science
  27. Hanrahan JD, Sargentoni J, Azzopardi D, et al. Cerebral metabolism within 18 hours of birth asphyxia: proton magnetic resonance spectroscopy study. Pediatr Res 1996;39:584-590
    PubMedWeb of Science
  28. Peden CJ, Cowan FM, Bryant DJ, et al. Proton MR spectroscopy of brain in infants. J Comput Assist Tomogr 1990;14:886-894
    CrossRefPubMedWeb of Science
  29. Cady EB, Amess P, Penrice J, Wylezinska M, Sams V, Wyatt JS. Early cerebral-metabolite quantification in perinatal hypoxic-ischemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy. Magn Reson Imaging 1997;15:605-611
    CrossRefPubMedWeb of Science
  30. ↵
    Bottomley PA. Spatial localization in NMR spectroscopy in vivo.. Ann N Y Acad Sci 1987;508:333-348
    CrossRefPubMedWeb of Science
  31. ↵
    Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med 1989;9:79-93
    CrossRefPubMedWeb of Science
  32. Haase A, Frahm J, Matthaei D, et al. MR imaging using stimulated echoes (STEAM). Radiology 1986;160:787-790
    PubMed
  33. ↵
    Sarnat HBO, Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 1976;33:696-705
    CrossRefPubMedWeb of Science
  34. ↵
    Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. AJNR Am J Neuroradiol 1992;13:959-972
    Abstract/FREE Full Text
  35. Dambska M, Dydyk L, Szreter T, Wozniewicz J, Myers RE. Topography of lesions in newborn and infant brains following cardiac arrest and resuscitation: damage to brain and hemispheres. Bio Neonate 1976;29:194-206
  36. Leech RW, Alvordm EC Jr. Anoxic-ischemic encephalopathy in human neonatal period. Arch Neurol 1977;34:109-113
    CrossRefPubMedWeb of Science
  37. Schneider H, Ballowitz L, Schachinger H, Hanefeld F, Droszus JU. Anoxic encephalopathy with predominant involvement of basal ganglia, brain stem and spinal cord in perinatal period: report on seven newborns. Acta Neuropathol 1975;32:287-298
    CrossRefPubMed
  38. ↵
    Ernst T, Hennig J. Improved water suppression of localized in vivo 1H spectroscopy. J Magn Reson B 1995;106:181-186
    CrossRefPubMed
  39. de Graaf AA, Bovee WMM. Improved quantification of in vivo 1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into spectral fitting. Magn Reson Med 1990;15:305-319
    CrossRefPubMedWeb of Science
  40. ↵
    Govindaraju V, Basus VJ, Matson GB, Maudsley AA. Measurement of chemical shifts and coupling constants for glutamate and glutamine. Magn Reson Med 1998;39:1011-1013
    CrossRefPubMed
  41. ↵
    Erecinska M, Nelson D, Wilson DF, Silver IA. Neurotransmitter amino acids in the CNS, I: regional changes in amino acid levels in rat brain during ischemia and reperfusion. Brain Res 1984;304:9-22
    CrossRefPubMedWeb of Science
  42. Hagberg H, Lehmann A, Sandberg M, Nystrom B, Jacobson I, Hamberger A. Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extra-cellular compartments. J Cereb Blood Flow Metab 1985;5:413-419
    CrossRefPubMedWeb of Science
  43. Spisni A. 1D Spectrum analysis. In: De Certaines JD, Bovee WWMJ, Podo F, eds. Magnetic Resonance Spectroscopy in Biology and Medicine. Oxford: Pergramon; 1992:31-58
  44. Cady EB. Clinical Magnetic Resonance Spectroscopy.. New York: Plenum; 1990:47-81
  45. ↵
    Mathur-De Ver R, Delporte C. Relaxation times of relevant nuclei in biological systems. In: De Certaines JD, Bovee WWMJ, Podo F, eds. Magnetic Resonance Spectroscopy in Biology and Medicine. Oxford: Pergramon; 1992:77-96
  46. ↵
    Moonen CT, von Kienlin M, van Zijl PC, et al. Comparison of single-shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy. NMR Biomed 1989;2:201-208
    CrossRefPubMed
  47. ↵
    Benveniste H, Warner D. The role of glutamatergic neurotransmission in ischemic brain damage. In: Ginsberg MD, Bogousslavslky J, eds. Cerebrovascular Disease, Pathophysiology, Diagnosis and Management. Malden, MA: Blackwell Science; 1998:393-402
  48. Meldrum BS. Antagonism of excitatory amino acids. In: Ginsberg MD, Bogousslavslky J, eds. Cerebrovascular Disease, Pathophysiology, Diagnosis and Management. Malden, MA: Blackwell Science; 1998:682-692
  49. ↵
    Stasheff SF, Anderson WW, Clerk S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science 1989;245:648-651
    Abstract/FREE Full Text
  50. Hu RQ, Davies JA. Glutamate receptor antagonists reduce spontaneous epileptiform activity in cortical wedge prepared from DBA/2 mice. Exp Brain Res 1997;115:311-318
    CrossRefPubMed
  51. ↵
    Mukherji SK. Clinical Applications of MR Spectroscopy.. New York: Wiley; 1998:1-32
  52. Ernst T, Hennig J. Coupling effects in volume selective 1H spectroscopy of major brain metabolites. Magn Reson Med 1991;21:82-96
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 21, Issue 1
1 Jan 2000
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Yonglin Pu, Qing-Feng Li, Chao-Mei Zeng, Jian Gao, Jing Qi, De-Xin Luo, Srikanth Mahankali, Peter T. Fox, Jia-Hong Gao
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy
American Journal of Neuroradiology Jan 2000, 21 (1) 203-212;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy
Yonglin Pu, Qing-Feng Li, Chao-Mei Zeng, Jian Gao, Jing Qi, De-Xin Luo, Srikanth Mahankali, Peter T. Fox, Jia-Hong Gao
American Journal of Neuroradiology Jan 2000, 21 (1) 203-212;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • MRI and spectroscopy in (near) term neonates with perinatal asphyxia and therapeutic hypothermia
  • Clinical Correlates of White Matter Blood Flow Perfusion Changes in Sturge-Weber Syndrome: A Dynamic MR Perfusion-Weighted Imaging Study
  • Xenon Provides Short-Term Neuroprotection in Neonatal Rats When Administered After Hypoxia-Ischemia
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Neuroimaging Delineation and Progression of SLSMD
  • fetal brain development of 10 weeks gestation
  • CHARGE fetal MRI clival cleft
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire