Research ArticlePediatric Neuroimaging
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy
Yonglin Pu, Qing-Feng Li, Chao-Mei Zeng, Jian Gao, Jing Qi, De-Xin Luo, Srikanth Mahankali, Peter T. Fox and Jia-Hong Gao
American Journal of Neuroradiology January 2000, 21 (1) 203-212;
Yonglin Pu
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Qing-Feng Li
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Chao-Mei Zeng
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Jian Gao
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Jing Qi
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
De-Xin Luo
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Srikanth Mahankali
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Peter T. Fox
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).
Jia-Hong Gao
aFrom The People's Hospital of The Beijing Medical University, Beijing, The People's Republic of China (Y.P., Q-F.L., C-M.Z., J.G., J.Q., D-X.L.), and Research Imaging Center, University of Texas Health Science Center, San Antonio, TX (Y.P., S.M., P.T.F., J-H.G.).

References
- ↵Rivkin MJ. Hypoxic-ischemic brain injury in the term newborn: neuropathology, clinical aspects and neuroimaging. Clin Perinatol 1997;24:607-625
- ↵Cotman CW, Iversen LL. Excitatory amino acids in the brain: focus on NMDA receptors. Trends Neurosci 1987;10:263-265
- ↵
- ↵Ottersen OP, Laake JH, Reichelt W, Haug FM, Torp R. Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses. J Chem Neuroanat 1996;12:1-14
- ↵Erecinska M, Silver IA. Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 1990;35:245-296
- Philis JW, O'Regan MH. Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Res 1996;730:150-164
- Kanthan R, Shuaib A, Griebel R, Miyashita H. Intracerebral human microdialysis: in vivo study of acute focal ischemic model of the human brain. Stroke 1995;26:870-873
- Podell M, Hadjiconstantinou M. Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy. Am J Vet Res 1997;58:451-456
- ↵Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic/ischemic brain damage. Ann Neurol 1986;19:105-111
- Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci 1987;10:299-302
- Choi D. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc Brain Metab Rev 1990;2:105-147
- ↵du Plessis AJ, Johnston MV. Hypoxic-ischemic brain injury in the newborn, cellular mechanisms and potential strategies for neuroprotection. Clin Perinatol 1997;24:627-654
- ↵Mason GF, Pan JW, Ponder SL, Twieg DB, Pohost GM, Hetherington HP. Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T. Magn Reson Med 1994;32:142-145
- ↵McConnell JR, Antonson DL, Ong CS, et al. Proton spectroscopy of brain glutamine in acute liver failure. Hepatology 1995;22:69-74
- ↵Ross B, Michaelis T. Clinical application of magnetic resonance spectroscopy. Magn Reson Q 1994;10:191-247
- Bachelard H, Badar-Goffer R. NMR spectroscopy in neurochemistry. J Neurochem 1993;61:412-429
- ↵
- ↵Connelly A, Cross JH, Gadian DG, Hunter JV, Kirkham FJ, Leonard JV. Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency. Pediatr Res 1993;33:77-81
- ↵
- Kauppinen RA, Pirttila TRM, Auriola SOK, Williams SR. Compartmentation of cerebral glutamate in situ as detected by 1H and 13C n.m.r. Biochem J 1994;298:121-127
- ↵Kreis R, Arcinue E, Ernst T, Shonk TK, Flores R, Ross BD. Hypoxic encephalopathy after near-drowning studied by quantitative 1H-magnetic resonance spectroscopy: metabolic changes and their prognostic value. J Clin Invest 1996;97:1142-1154
- ↵Huppi PS, Barnes PD. Magnetic resonance techniques in the evaluation of newborn brain. Clin Perinatol 1997;24:693-723
- Penrice J, Cady EB, Lorek A, et al. Proton magnetic resonance spectroscopy of brain in normal preterm and term infants, and early changes following perinatal hypoxia-ischemia. Pediatr Res 1996;40:6-14
- Groenendaal F, Veenhoven RH, Van Der Grond J, Jansen GH, Witkamp TD, De Vries LS. Cerebral lactate and N-acetyl-aspartate/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Pediatr Res 1994;35:148-151
- Peden CJ, Rutherford MA, Sargentoni J, Cox IJ, Bryant DJ, Dubowitz LMS. Proton spectroscopy of the neonatal brain following hypoxic-ischemic injury. Dev Med Child Neurol 1993;35:502-510
- Hanrahan JD, Sargentoni J, Azzopardi D, et al. Cerebral metabolism within 18 hours of birth asphyxia: proton magnetic resonance spectroscopy study. Pediatr Res 1996;39:584-590
- Peden CJ, Cowan FM, Bryant DJ, et al. Proton MR spectroscopy of brain in infants. J Comput Assist Tomogr 1990;14:886-894
- Cady EB, Amess P, Penrice J, Wylezinska M, Sams V, Wyatt JS. Early cerebral-metabolite quantification in perinatal hypoxic-ischemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy. Magn Reson Imaging 1997;15:605-611
- ↵Bottomley PA. Spatial localization in NMR spectroscopy in vivo.. Ann N Y Acad Sci 1987;508:333-348
- ↵Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med 1989;9:79-93
- Haase A, Frahm J, Matthaei D, et al. MR imaging using stimulated echoes (STEAM). Radiology 1986;160:787-790
- ↵Sarnat HBO, Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 1976;33:696-705
- ↵Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. AJNR Am J Neuroradiol 1992;13:959-972
- Dambska M, Dydyk L, Szreter T, Wozniewicz J, Myers RE. Topography of lesions in newborn and infant brains following cardiac arrest and resuscitation: damage to brain and hemispheres. Bio Neonate 1976;29:194-206
- Leech RW, Alvordm EC Jr. Anoxic-ischemic encephalopathy in human neonatal period. Arch Neurol 1977;34:109-113
- ↵
- de Graaf AA, Bovee WMM. Improved quantification of in vivo 1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into spectral fitting. Magn Reson Med 1990;15:305-319
- ↵
- ↵Erecinska M, Nelson D, Wilson DF, Silver IA. Neurotransmitter amino acids in the CNS, I: regional changes in amino acid levels in rat brain during ischemia and reperfusion. Brain Res 1984;304:9-22
- Hagberg H, Lehmann A, Sandberg M, Nystrom B, Jacobson I, Hamberger A. Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extra-cellular compartments. J Cereb Blood Flow Metab 1985;5:413-419
- Spisni A. 1D Spectrum analysis. In: De Certaines JD, Bovee WWMJ, Podo F, eds. Magnetic Resonance Spectroscopy in Biology and Medicine. Oxford: Pergramon; 1992:31-58
- Cady EB. Clinical Magnetic Resonance Spectroscopy.. New York: Plenum; 1990:47-81
- ↵Mathur-De Ver R, Delporte C. Relaxation times of relevant nuclei in biological systems. In: De Certaines JD, Bovee WWMJ, Podo F, eds. Magnetic Resonance Spectroscopy in Biology and Medicine. Oxford: Pergramon; 1992:77-96
- ↵
- ↵Benveniste H, Warner D. The role of glutamatergic neurotransmission in ischemic brain damage. In: Ginsberg MD, Bogousslavslky J, eds. Cerebrovascular Disease, Pathophysiology, Diagnosis and Management. Malden, MA: Blackwell Science; 1998:393-402
- Meldrum BS. Antagonism of excitatory amino acids. In: Ginsberg MD, Bogousslavslky J, eds. Cerebrovascular Disease, Pathophysiology, Diagnosis and Management. Malden, MA: Blackwell Science; 1998:682-692
- ↵Stasheff SF, Anderson WW, Clerk S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science 1989;245:648-651
- ↵Mukherji SK. Clinical Applications of MR Spectroscopy.. New York: Wiley; 1998:1-32
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Yonglin Pu, Qing-Feng Li, Chao-Mei Zeng, Jian Gao, Jing Qi, De-Xin Luo, Srikanth Mahankali, Peter T. Fox, Jia-Hong Gao
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy
American Journal of Neuroradiology Jan 2000, 21 (1) 203-212;
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