Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

The Effect of Age on Odor-Stimulated Functional MR Imaging

David M. Yousem, Joseph A. Maldjian, Thomas Hummel, David C. Alsop, Rena J. Geckle, Michael A. Kraut and Richard L. Doty
American Journal of Neuroradiology April 1999, 20 (4) 600-608;
David M. Yousem
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph A. Maldjian
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Hummel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David C. Alsop
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rena J. Geckle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael A. Kraut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard L. Doty
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Yousem DM, Williams SC, Howard RO, et al. Functional MR imaging during odor stimulation: preliminary data. Radiology 1997;204:833-838
    PubMedWeb of Science
  2. Levy LM, Henkin RI, Hutter A, Lin CS, Martins D, Schellinger D. Functional MRI of human olfaction. J Comput Assist Tomogr 1997;21:849-856
    CrossRefPubMedWeb of Science
  3. Levy LM, Henkin RI, Hutter A, Lin CS, Schellinger D. Mapping brain activation to odorants in patients with smell loss by functional MRI. J Comput Assist Tomogr 1998;22:96-103
    CrossRefPubMedWeb of Science
  4. Koizuka I, Yano H, Nagahara M, et al. Functional imaging of the human olfactory cortex by magnetic resonance imaging. ORL J Otorhinolaryngol Relat Spec 1994;56:273-275
    PubMed
  5. Kettenmann B, Jousmaki V, Portin K, Salmelin R, Kobal G, Hari R. Odorants activate the human superior temporal sulcus. Neurosci Lett 1996;203:143-145
    CrossRefPubMedWeb of Science
  6. Sobel N, Prabhakaran V, Hartley CA, et al. Odorant-induced and sniff-induced activation in the cerebellum of the human. J Neurosci 1998;18:8990-9001
    Abstract/FREE Full Text
  7. ↵
    Doty RL. Influence of age and age-related diseases on olfactory function. Ann N Y Acad Sci 1989;561:76-86
    PubMedWeb of Science
  8. ↵
    Doty RL, Applebaum S, Zusho H, Settle RG. Sex differences in odor identification ability: a cross-cultural analysis. Neuropsychologia 1985;23:667-672
    CrossRefPubMedWeb of Science
  9. ↵
    Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav 1978;20:175-185
    CrossRefPubMedWeb of Science
  10. ↵
    Deems DA, Doty RL. Age-related changes in the phenyl ethyl alcohol odor detection threshold. Trans Penn Acad Ophthalmol Otolaryngol 1987;39:646-650
  11. ↵
    Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984;94:176-178
    CrossRefPubMedWeb of Science
  12. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984;32:489-502
    CrossRefPubMedWeb of Science
  13. ↵
    Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. Smell identification ability: changes with age. Science 1984;226:1441-1443
    Abstract/FREE Full Text
  14. ↵
    Kopala LC, Good K, Honer WG. Olfactory identification ability in pre- and postmenopausal women with schizophrenia. Biol Psychiatry 1995;38:57-63
    CrossRefPubMedWeb of Science
  15. Murphy C. Cognitive and chemosensory influences on age-related changes in the ability to identify blended foods. J Gerontol 1985;40:47-52
    Abstract/FREE Full Text
  16. Murphy C. Age-related effects on the threshold, psychophysical function, and pleasantness of menthol. J Gerontol 1983;38:217-222
    Abstract/FREE Full Text
  17. ↵
    Briggs GG, Nebes RD. Patterns of hand preference in a student population. Cortex 1975;11:230-238
    CrossRefPubMed
  18. Deems DA, Doty RL, Settle RG, et al. Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 1991;117:519-528
  19. Hummel T, Pietsch H, Kobal G. Kallmann's syndrome and chemosensory evoked potentials. Eur Arch Otorhinolaryngol 1991;248:311-312
    PubMed
  20. ↵
    Kobal G, Hummel C. Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroencephalogr Clin Neurophysiol 1988;71:241-250
    CrossRefPubMedWeb of Science
  21. ↵
    Sobel N, Prabhakaran V, Desmond JE, et al. Sniffing and smelling: separate subsystems in the human olfactory cortex. Nature 1998;392:282-286
    CrossRefPubMedWeb of Science
  22. ↵
    Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991;11:690-699
    CrossRefPubMedWeb of Science
  23. Friston KJ, Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans AC. Assessing the significance of focal activations using their spatial extent. Hum Brain Map 1994;1:214-220
  24. Friston KJ. Commentary and opinion, II: statistical parametric mapping: ontology and current issues. J Cereb Blood Flow Metab 1995;15:361-370
    CrossRefPubMedWeb of Science
  25. ↵
    Friston K, Holmes A, Worsley K, Poline J, Frith C, Frackowiak R. Statistical parametric maps in functional imaging: a general approach. Hum Brain Map 1995;2:189-201
    CrossRef
  26. ↵
    Friston K, Ahburner J, Poline J, Frith C, Heather J, Frackowiak R. Spatial realignment and normalization of images. Hum Brain Map 1995;2:202-214
  27. Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS. The relationship between global and local changes in PET scans [see comments]. J Cereb Blood Flow Metab 1990;10:458-466
    PubMedWeb of Science
  28. ↵
    Levin JM, Ross MH, Mendelson JH, Mello NK, Cohen BM, Renshaw PF. Sex differences in blood-oxygenation-level-dependent functional MRI with primary visual stimulation. Am J Psychiatry 1998;155:434-436
    PubMedWeb of Science
  29. Gur RC, Gur RE, Obrist WD, et al. Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science 1982;217:659-661
    Abstract/FREE Full Text
  30. ↵
    Gur RC, Mozley LH, Mozley PD, et al. Sex differences in regional cerebral glucose metabolism during a resting state. Science 1995;267:528-531
    Abstract/FREE Full Text
  31. ↵
    Andreason PJ, Zametkin AJ, Guo AC, Baldwin P, Cohen RM. Gender-related differences in regional cerebral glucose metabolism in normal volunteers. Psychiatry Res 1994;51:175-183
    CrossRefPubMedWeb of Science
  32. ↵
    Miura SA, Schapiro MB, Grady CL, et al. Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study. J Neurosci Res 1990;27:500-504
    CrossRefPubMedWeb of Science
  33. ↵
    Azari NP, Rapoport SI, Salerno JA, et al. Interregional correlations of resting cerebral glucose metabolism in old and young women. Brain Res 1992;589:279-290
    CrossRefPubMedWeb of Science
  34. ↵
    Grady CL, Maisog JM, Horwitz B, et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci 1994;14:1450-1462
    Abstract
  35. ↵
    Ross MH, Yurgelun-Todd DA, Renshaw PF, et al. Age-related reduction in functional MRI response to photic stimulation. Neurology 1997;48:173-176
    Abstract/FREE Full Text
  36. ↵
    Hatazawa J, Brooks RA, Di Chiro G, Campbell G. Global cerebral glucose utilization is independent of brain size: a PET study. J Comput Assist Tomogr 1987;11:571-576
    PubMedWeb of Science
  37. ↵
    Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E. Functional localization and lateralization of human olfactory cortex. Nature 1992;360:339-340
    CrossRefPubMed
  38. ↵
    Kraut MA, Marenco S, Soher BJ, Wong DF, Bryan RN. Comparison of functional MR and H2 15O positron emission tomography in stimulation of the primary visual cortex. AJNR Am J Neuroradiol 1995;16:2101-2107
    Abstract
  39. Kraut M, Hart J Jr, Soher BJ, Gordon B. Object shape processing in the visual system evaluated using functional MRI. Neurology 1997;48:1416-1420
    Abstract/FREE Full Text
  40. ↵
    Gilbert AN, Greenberg MS, Beauchamp GK. Sex, handedness and side of nose modulate human odor perception [published erratum appears in Neuropsychologia 1989;27:1313]. Neuropsychologia 1989;27:505-511
    CrossRefPubMedWeb of Science
  41. ↵
    Evans WJ, Cui L, Starr A. Olfactory event-related potentials in normal human subjects: effects of age and gender. Electroencephalogr Clin Neurophysiol 1995;95:293-301
    CrossRefPubMedWeb of Science
  42. ↵
    Cowell PE, Turetsky BI, Gur RC, Grossman RI, Shtasel DL, Gur RE. Sex differences in aging of the human frontal and temporal lobes. J Neurosci 1994;14:4748-4755
    Abstract
  43. Gur RC, Mozley PD, Resnick SM, et al. Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sci U S A 1991;88:2845-2849
    Abstract/FREE Full Text
  44. ↵
    Gur RE, Gur RC. Gender differences in regional cerebral blood flow. Schizophrenia Bull 1990;16:247-254
  45. ↵
    Doty RL, Reyes PF, Gregor T. Presence of both odor identification and detection deficits in Alzheimer's disease. Brain Res Bull 1987;18:597-600
    CrossRefPubMedWeb of Science
  46. Doty RL. Olfactory capacities in aging and Alzheimer's disease: psychophysical and anatomic considerations. Ann NY Acad Sci 1991;640:20-27
    PubMedWeb of Science
  47. Doty RL, Perl DP, Steele JC, et al. Olfactory dysfunction in three neurodegenerative diseases. Geriatrics 1991;46:47-51
  48. ↵
    Serby M, Larson P, Kalkstein D. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry 1991;148:357-360
    PubMedWeb of Science
  49. Rezek DL. Olfactory deficits as a neurologic sign in dementia of the Alzheimer type. Arch Neurol 1987;44:1030-1032
    CrossRefPubMedWeb of Science
  50. ↵
    Bacon AW, Hartwell V, Quinones R, et al. The role of apolipoprotein-E and olfactory functioning in people with Alzheimer's disease. Presented at the International Symposium on Smell and Taste, San Diego, 1997
  51. ↵
    Doty RL, Li C, Mannon LJ, Yousem DM. Olfactory dysfunction in multiple sclerosis [letter]. N Engl J Med 1997;336:1918-1919
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 20, Issue 4
1 Apr 1999
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Effect of Age on Odor-Stimulated Functional MR Imaging
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
David M. Yousem, Joseph A. Maldjian, Thomas Hummel, David C. Alsop, Rena J. Geckle, Michael A. Kraut, Richard L. Doty
The Effect of Age on Odor-Stimulated Functional MR Imaging
American Journal of Neuroradiology Apr 1999, 20 (4) 600-608;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
The Effect of Age on Odor-Stimulated Functional MR Imaging
David M. Yousem, Joseph A. Maldjian, Thomas Hummel, David C. Alsop, Rena J. Geckle, Michael A. Kraut, Richard L. Doty
American Journal of Neuroradiology Apr 1999, 20 (4) 600-608;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Functional MRI as an Objective Measure of Olfaction Deficit in Patients with Traumatic Anosmia
  • Olfactory Loss in Aging
  • Anosmia in dementia is associated with Lewy bodies rather than Alzheimer's pathology
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire