Abstract
BACKGROUND AND PURPOSE: Our objective was to develop a method to correct for the effect of partial volume averaging (PVA) in the CT measurement of contrast enhancement in small arteries, and to validate a dynamic contrast-enhanced CT method for the measurement of regional cerebral blood flow (rCBF).
METHODS: Contrast-enhanced CT scans of tubes of known inner diameters were obtained to estimate the size-dependent scaling factors (PVSF) due to PVA. The background-subtracted image profiles of the contrast-filled tubes were fitted to gaussian curves, and the standard deviations (SDs) of these curves were correlated with the PVSF of each tube. In the second part of this investigation, 13 studies were performed in six New Zealand white rabbits under normal conditions. Dynamic CT measurements of rCBF, regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) were calculated in the left and right parietal lobes and the basal ganglia. The CT rCBF values were compared with those obtained by the microsphere method, which is the standard of reference.
RESULTS: We found strong correlations for the SDs of the gaussian curves to the known inner diameters of the tubes and to their size-related PVSF. These correlations demonstrated that the error from PVA in the measurement of arterial enhancement can be corrected without knowledge of the actual size of the artery. The animal studies revealed a mean (±SD) rCBF of 73.3 ± 31.5 mL/100 g per minute, a mean rCBV of 1.93 ± 0.74 mL/100 g, and a mean rMTT of 1.81 ± 1.02 seconds. A strong correlation was found between rCBF values derived by the CT and the microsphere methods.
CONCLUSION: We have validated a new dynamic CT method for measuring rCBF. The accuracy of this technique suggests that it can be used as an alternative diagnostic tool to assess the cerebral hemodynamics in experimental and clinical situations.
- Copyright © American Society of Neuroradiology
In this issue
Jump to section
Related Articles
Cited By...
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath hold maneuver
- Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation
- CT Perfusion Mean Transit Time Maps Optimally Distinguish Benign Oligemia from True "At-Risk" Ischemic Penumbra, but Thresholds Vary by Postprocessing Technique
- Early Rate of Contrast Extravasation in Patients with Intracerebral Hemorrhage
- Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT
- Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association
- CT Perfusion of the Neck: Internal Carotid Artery versus External Carotid Artery as the Reference Artery
- Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 2: Technical Implementations
- Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis
- CT Angiography Clot Burden Score and Collateral Score: Correlation with Clinical and Radiologic Outcomes in Acute Middle Cerebral Artery Infarct
- CT Perfusion Imaging in Cerebral Ischemia
- Brain imaging using multislice CT: a personal perspective
- Assessment of the Reproducibility of Postprocessing Dynamic CT Perfusion Data
- Perfusion CT for the assessment of tumour vascularity: which protocol?
- Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke
- Perfusion CT: a worthwhile enhancement?
- Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association
- Quantification of Perfusion Using Bolus Tracking Magnetic Resonance Imaging in Stroke: Assumptions, Limitations, and Potential Implications for Clinical Use
- Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:: Prediction of Final Infarct Volume and Clinical Outcome Editorial Comment: Prediction of Final Infarct Volume and Clinical Outcome
- Simultaneous Measurement of Regional Cerebral Blood Flow by Perfusion CT and Stable Xenon CT: A Validation Study
- Perfusion Mapping Using Computed Tomography Allows Accurate Prediction of Cerebral Infarction in Experimental Brain Ischemia Editorial Comment
- A CT Method to Measure Hemodynamics in Brain Tumors: Validation and Application of Cerebral Blood Flow Maps