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Abstract

Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast.

S Bastianello, C Gasperini, A Paolillo, E Giugni, O Ciccarelli, M P Sormani, M A Horsfield, M Rovaris, C Pozzilli and M Filippi
American Journal of Neuroradiology November 1998, 19 (10) 1863-1867;
S Bastianello
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C Gasperini
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A Paolillo
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E Giugni
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O Ciccarelli
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M P Sormani
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M A Horsfield
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M Rovaris
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C Pozzilli
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M Filippi
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Abstract

BACKGROUND AND PURPOSES New strategies have been developed to improve the sensitivity of contrast-enhanced MR imaging in quantifying disease activity in patients with multiple sclerosis (MS). The goal of the present study was to evaluate the sensitivity of T1-weighted images after injection of a triple dose of contrast material and application of a magnetization transfer (MT) pulse in the detection of enhancing lesions as compared with the conventional approach.

METHODS Monthly MR images were obtained in 13 patients with relapsing-remitting MS for a period of 3 months. The MR studies were performed on two separate occasions with single- and triple-dose contrast material. In each session, T1- and T2-weighted spin-echo images with and without the MT pulse were obtained before and after contrast administration. All images were evaluated in a blinded fashion and scored in random order and consensually by two readers. The number of total and new enhancing lesions and active images was counted.

RESULTS Eighty-six percent more enhancing lesions and 54% more new enhancing lesions were detected with triple-dose as compared with single-dose non-MT sequences, whereas single-dose MT images depicted 33% more enhancing lesions and 18% more new enhancing lesions than the single-dose non-MT images. Twenty-nine percent more lesions were detected on triple-dose non-MT images than on single-dose MT images. The combination of a triple dose of contrast material and MT did not produce any significant change in detection of enhancing lesions as compared with a triple dose of contrast without MT.

CONCLUSION The use of a triple dose of contrast material is the best approach to maximize the sensitivity of enhanced MR imaging.

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American Journal of Neuroradiology
Vol. 19, Issue 10
1 Nov 1998
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S Bastianello, C Gasperini, A Paolillo, E Giugni, O Ciccarelli, M P Sormani, M A Horsfield, M Rovaris, C Pozzilli, M Filippi
Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast.
American Journal of Neuroradiology Nov 1998, 19 (10) 1863-1867;

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Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast.
S Bastianello, C Gasperini, A Paolillo, E Giugni, O Ciccarelli, M P Sormani, M A Horsfield, M Rovaris, C Pozzilli, M Filippi
American Journal of Neuroradiology Nov 1998, 19 (10) 1863-1867;
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