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Clinical/translational cancer immunotherapy
Original research
Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies

Authors

  • Weifeng Zhang Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Xueling Chen Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Xingxing Chen Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Jirui Li Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Hui Wang Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Xiaomiao Yan Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, ChinaJinxin Research Institute for Reproductive Medicine and Genetics, Xinan Hospital for Maternal and Child Health Care, Chengdu, China PubMed articlesGoogle scholar articles
  • Han Zha The People's Hospital of Qijiang District Chongqing, Chongqing, China PubMed articlesGoogle scholar articles
  • Xiaonan Ma Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Chanyuan Zhao Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Meng Su Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Liangli Hong Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Penghao Li Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, ChinaJinxin Research Institute for Reproductive Medicine and Genetics, Xinan Hospital for Maternal and Child Health Care, Chengdu, China PubMed articlesGoogle scholar articles
  • Yanyu Ling Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Wenhui Zhao Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China PubMed articlesGoogle scholar articles
  • Yu Xia Akeso Biopharma Inc, Zhongshan, China PubMed articlesGoogle scholar articles
  • Baiyong Li Akeso Biopharma Inc, Zhongshan, China PubMed articlesGoogle scholar articles
  • Tianjing Zheng Chia Tai Tianqing Pharmaceutical Group Co., LTD, Nanjing, China PubMed articlesGoogle scholar articles
  • Jiang Gu Guangdong Provincial International Collaborative Center of Molecular Medicine, Center of Collaboration and Creative, Molecular Diagnosis and Personalized Medical, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, ChinaJinxin Research Institute for Reproductive Medicine and Genetics, Xinan Hospital for Maternal and Child Health Care, Chengdu, China PubMed articlesGoogle scholar articles

Citation

Zhang W, Chen X, Chen X, et al
Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies
Journal for ImmunoTherapy of Cancer 2024;12:e009034. doi: 10.1136/jitc-2024-009034
Online issue publication 
June 25, 2024

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Copyright information

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.