Journal for ImmunoTherapy of Cancer: 12 (6)

Editorial

Perspectives from the leadership of Journal for ImmunoTherapy of Cancer
(19 June, 2024)
Sjoerd H van der Burg, Michael T Lotze

Basic tumor immunology

Original research: Tumor cell-released autophagosomes (TRAPs) induce PD-L1-decorated NETs that suppress T-cell function to promote breast cancer pulmonary metastasis (26 June, 2024)
Xiaohe Zhou, Chengdong Wu, Xuru Wang, Ning Pan, Xiaotong Sun, Bohao Chen, Shiya Zheng, Yiting Wei, Jing Chen, Yuyang Wu, Fengjiao Zhu, Jinpeng Chen, Huabiao Chen, Li-xin Wang
Original research: Expression of VISTA regulated via IFN-γ governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice (25 June, 2024)
Donghai Tang, Li Zhao, Fen Yan, Chunxiao Ren, Kailin Xu, Kai Zhao
Original research: Protein O-fucosyltransferase 1 promotes PD-L1 stability to drive immune evasion and directs liver cancer to immunotherapy (21 June, 2024)
Qianyu Li, Wenyun Guo, Yifei Qian, Songling Li, Linfeng Li, Zijun Zhu, Fan Wang, Yu Tong, Qiang Xia, Yanfeng Liu
Original research: Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect (21 June, 2024)
Conghua Lu, Ziyuan Gao, Di Wu, Jie Zheng, Chen Hu, Daijuan Huang, Chao He, Yihui Liu, Caiyu Lin, Tao Peng, Yuanyao Dou, Yimin Zhang, Fenfen Sun, Weiling Jiang, Guoqing Yin, Rui Han, Yong He
Single-cell sequencing unveils extensive intratumoral heterogeneity of cancer/testis antigen expression in melanoma and lung cancer (17 June, 2024)
Sofie Traynor, Mie K Jakobsen, Tina M Green, Hana Komic, Yaseelan Palarasah, Christina B Pedersen, Henrik J Ditzel, Fredrik B Thoren, Per Guldberg, Morten F Gjerstorff
Original research: Molecular mechanisms underlying the modulation of T-cell proliferation and cytotoxicity by immobilized CCL21 and ICAM1 (12 June, 2024)
Sofi Yado, Bareket Dassa, Rawan Zoabi, Shlomit Reich-Zeliger, Nir Friedman, Benjamin Geiger
Original research: Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma (4 June, 2024)
Ryan P O’Connell, Kevin Liaw, Nils Wellhausen, Christopher A Chuckran, Pratik S Bhojnagarwala, Devivasha Bordoloi, Daniel Park, Nicholas Shupin, Daniel Kulp, Carl H June, David Weiner

Clinical/translational cancer immunotherapy

Original research: Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies (25 June, 2024)
Weifeng Zhang, Xueling Chen, Xingxing Chen, Jirui Li, Hui Wang, Xiaomiao Yan, Han Zha, Xiaonan Ma, Chanyuan Zhao, Meng Su, Liangli Hong, Penghao Li, Yanyu Ling, Wenhui Zhao, Yu Xia, Baiyong Li, Tianjing Zheng, Jiang Gu
Original research: Single-arm study of camrelizumab plus apatinib for patients with advanced mucosal melanoma (21 June, 2024)
Lianjun Zhao, Yu Ren, Guiying Zhang, Kelin Zheng, Jiayu Wang, Huizi Sha, Mengke Zhao, Rong Huang, Donglin Kang, Xinyu Su, Yirong Wu, Wangling Zhang, Ruihe Lai, Lin Li, Rui Mei, Yitao Wang, You Tian, Fufeng Wang, Baorui Liu, Zhengyun Zou
Original research: Integrated analysis of tertiary lymphoid structures and immune infiltration in ccRCC microenvironment revealed their clinical significances: a multicenter cohort study (21 June, 2024)
Yu-Qi Wang, Wen-Jin Chen, Wang Zhou, Ke-Qin Dong, Li Zuo, Da Xu, Jia-Xin Chen, Wei-Jie Chen, Wen-Yan Li, Zi-Chang Liu, Zheng-Yu Jiang, Yi-Fan Tang, Yu-Xuan Qin, Lin-Hui Wang, Xiu-Wu Pan, Xin-Gang Cui
Original research: Complex immune microenvironment of chordoma: a road map for future treatment (21 June, 2024)
Hua-Qing Niu, Bo-Yv Zheng, Ming-Xiang Zou, Bo-Wen Zheng
Original research: Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial (11 June, 2024)
Jiwei Huang, Yueming Wang, Fan Xu, Zaoyu Wang, Guangyu Wu, Wen Kong, NG Cheoklong, Thibault Tricard, Xiaorong Wu, Wei Zhai, Wei Zhang, Jiyang Zhang, Ding Zhang, Shuyin Chen, Yuqing Lian, Yonghui Chen, Jin Zhang, Yiran Huang, Wei Xue
Original research: Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes (10 June, 2024)
Junha Cha, Da Hee Kim, Gamin Kim, Jae-Won Cho, Euijeong Sung, Seungbyn Baek, Min Hee Hong, Chang Gon Kim, Nam Suk Sim, Hyun Jun Hong, Jung Eun Lee, Martin Hemberg, Seyeon Park, Sun Ock Yoon, Sang-Jun Ha, Yoon Woo Koh, Hye Ryun Kim, Insuk Lee
Blinatumomab as postremission therapy replaces consolidation and substantial parts of maintenance chemotherapy and results in stable MRD negativity in children with newly diagnosed B-lineage ALL (6 June, 2024)
Ekaterina Mikhailova, Alexander Popov, Julia Roumiantseva, Oleg Budanov, Svetlana Lagoyko, Liudmila Zharikova, Natalia Miakova, Dmitry Litvinov, Lili Khachatryan, Alexey Pshonkin, Natalia Ponomareva, Elmira Boichenko, Svetlana Varfolomeeva, Julia Dinikina, Galina Novichkova, Guenter Henze, Alexander Karachunskiy
Original research: Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma (6 June, 2024)
Joseph J Sacco, Richard D Carvajal, Marcus O Butler, Alexander N Shoushtari, Jessica C Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M Piulats, Matthew Rioth, Douglas B Johnson, Jason J Luke, Enrique Espinosa, Serge Leyvraz, Laura Collins, Chris Holland, Takami Sato

Immune cell therapies and immune cell engineering

Original research: Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells (30 June, 2024)
Megen C Wittling, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Gregory B Lesinski, Chrystal M Paulos
Original research: EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion (17 June, 2024)
Yuanyuan Chen, Dijun Ouyang, Yan Wang, Qiuzhong Pan, Jingjing Zhao, Hao Chen, Xinyi Yang, Yan Tang, Qijing Wang, Yongqiang Li, Jia He, Jin-Qi You, Yingzi Li, Chi Xu, Yan Ren, Sisi Xie, Song Li, Jiamin Lian, Desheng Weng, Tong Xiang, Jian-Chuan Xia

Immunotherapy biomarkers

Original research: Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma (30 June, 2024)
Jessica S W Borgers, Tineke J van Wesemael, Kyra A Gelderman, Theo Rispens, Els M E Verdegaal, Dirk J A R Moes, Catharina M Korse, Ellen Kapiteijn, Marij J P Welters, Sjoerd H van der Burg, Winan J van Houdt, Johannes V van Thienen, John B A G Haanen, Diane van der Woude
Original research:
Correlation of K^trans derived from dynamic contrast-enhanced MRI with treatment response and survival in locally advanced NSCLC patients undergoing induction immunochemotherapy and concurrent chemoradiotherapy
(23 June, 2024)
DaQuan Wang, SongRan Liu, Jia Fu, PengXin Zhang, ShiYang Zheng, Bo Qiu, Hui Liu, YongQuan Ye, JinYu Guo, Yin Zhou, HaiHang Jiang, ShaoHan Yin, HaoQiang He, ChuanMiao Xie, Hui Liu
Original research: Circulating receptor activator of nuclear factor kappa-B ligand (RANKL) levels predict response to immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC) (21 June, 2024)
Michele Iuliani, Sonia Simonetti, Leonardo Cristofani, Silvia Cavaliere, Alessio Cortellini, Marco Russano, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini, Francesco Pantano
Original research:
Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by ¹⁸F-BMS-986192 PET: pooled analysis of data from four solid tumor types
(17 June, 2024)
Iris H C Miedema, Johanna E. E. Pouw, Anne Kwakman, Gerben J C Zwezerijnen, Marc C Huisman, Florentine E F Timmer, Rieneke van de Ven, Tanja D de Gruijl, Geke A P Hospers, Adrianus J de Langen, C Willemien Menke-van der Houven van Oordt
Original research: HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype (13 June, 2024)
Fan Luo, Jiaxin Cao, Qun Chen, Lusha Liu, Ting Yang, Xue Bai, Wenjuan Ma, Chaozhuo Lin, Ting Zhou, Jianhua Zhan, Yan Huang, Yunpeng Yang, Hongyun Zhao, Li Zhang
Original research: High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC) (10 June, 2024)
Myrto K Moutafi, Katherine M Bates, Thazin Nwe Aung, Rolando Garcia Milian, Vasiliki Xirou, Ioannis A Vathiotis, Niki Gavrielatou, Athanasios Angelakis, Kurt A Schalper, Leonidas Salichos, David L Rimm
Original research: Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma (6 June, 2024)
Chengpei Zhu, Chenchen Zhang, Shanshan Wang, Ziyu Xun, Dongya Zhang, Zhou Lan, Longhao Zhang, Jiashuo Chao, Yajun Liang, Zilun Pu, Cong Ning, Xinting Sang, Xiaobo Yang, Hanping Wang, Xianzhi Jiang, Haitao Zhao

Hypothesis

Hypothesis: AdAPT-001 and pseudoprogression – when seeing is not necessarily believing (17 June, 2024)
Anthony Conley, Christopher Larson, Bryan Oronsky, Meaghan Stirn, Scott Caroen, Tony R Reid

Position article and guidelines

Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision (19 June, 2024)
Leisha A Emens, Pedro J Romero, Ana Carrizosa Anderson, Tullia C Bruno, Christian M Capitini, Deborah Collyar, James L Gulley, Patrick Hwu, Avery D Posey, Ann W Silk, Jennifer A Wargo

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Table of contents

June 2024 - Volume 12 - 6

Editorial

Basic tumor immunology

Clinical/translational cancer immunotherapy

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Hypothesis

Position article and guidelines

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Table of contents

June 2024 - Volume 12 - 6

Editorial

Basic tumor immunology

Clinical/translational cancer immunotherapy

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Hypothesis

Position article and guidelines