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  • Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

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Basic tumor immunology
Original research
Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

Authors

  • Maria Alejandra Garcia-Marquez Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Martin Thelen Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Eugen Bauer Institute of Transfusion Medicine, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Lukas Maas Department of Translational Genomics, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Kerstin Wennhold Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Jonas Lehmann Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Diandra Keller Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Miloš Nikolić Department of Translational Genomics, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Julie George Department of Translational Genomics, University of Cologne, Cologne, GermanyDepartment of Otorhinolaryngology Head and Neck Surgery, University Hospital Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Thomas Zander Department I of Internal Medicine and Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Wolfgang Schröder Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Philipp Müller Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyInstitute of Pathology, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Ali M Yazbeck Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyInstitute of Pathology, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Christiane Bruns Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Roman Thomas Department of Translational Genomics, University of Cologne, Cologne, GermanyInstitute of Pathology, University of Cologne, Cologne, GermanyGerman Cancer Consortium (DKTK), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Birgit Gathof Institute of Transfusion Medicine, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Alexander Quaas Institute of Pathology, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Martin Peifer Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of Translational Genomics, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Axel M Hillmer Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyInstitute of Pathology, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles
  • Michael von Bergwelt-Baildon German Cancer Consortium (DKTK), Heidelberg, GermanyGene Centre, Ludwig Maximilians University Munich, Munchen, GermanyDepartment of Medicine III, Ludwig Maximilians University Munich, Munchen, Germany PubMed articlesGoogle scholar articles
  • Hans Anton Schlößer Center for Molecular Medicine Cologne, University of Cologne, Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany PubMed articlesGoogle scholar articles

Citation

Garcia-Marquez MA, Thelen M, Bauer E, et al
Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides
Journal for ImmunoTherapy of Cancer 2024;12:e007268. doi: 10.1136/jitc-2023-007268
Online issue publication 
April 17, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.