{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QLCfrMdBhRZJ2f5L6kgCYV8KvwqMy05ZC6\\\\\\\\\\\\\\\/d1c51IXwaK0QwgrSXq+sKkF+qWLflGYkKtclKsoatL70DQMkO+yUhOMiZoXuaDuTO2TAfeHHbQA7tqi3ZzygmJfimABNJNdB9vtKDJgv\\\\\\\\\\\\\\\/XGPa5QYDufEqUxhwOaCCR+DSeSqn0pDroOm6ZPWL6plT4Q\\\\\\\\\\\\\\\/A3NY7pXS5piIMsYnNEXCryDrBlrfLqIqRQ8Bj\\\\\\\\\\\\\\\/PgyMPCeIgpnI8wT5PQI0hYqbkBMKHPmL7xqoPcBssFiZh8rzLCu4sbxQY+wApUtnmSCZMkGIvIDOzh+xQ4vY9LtAteX97cmpGVtSW45ONBWr44OuRo2a\\\\\\\\\\\\\\\/V1D\\\\\\\\\\\\\\\/+REKL2qoyP3KHD0rwd1gG5\\\\\\\\\\\\\\\/AMe3pCwzw4aGz615ViQMeCF4mjaufw9o9Eol3JurRuMnaDUTt0Dg4Q2aoab1EQcAxnpHNlNWhiVT1tuGHCMaiAA0aD7PquQBJIMSmrnqQ32yoeysaCE+4C8elcSkvAIUa45O+LNwcKClC+MHs3lW6nEwQKzcXJrlqJvD1y\\\\\\\\\\\\\\\/5p68Oupxcgp9L3B7f3wYPvmFfre1R1tmWLRVMJ6ttQAkoMHliXwEgbXTpdx+n67wGXIg5G88paOjlmSrOM5PwSLwW77P\\\\\\\\\\\\\\\/ugyc4lMCTd1Y8tv+\\\\\\\\\\\\\\\/PZalvQKs1yASsHir5OCdg4WzPMqP2cL4IZcZKwLv5i+\\\\\\\\\\\\\\\/aPeeB33o5YzQDP8yTNI4IwOdSVh6jL6ogqWUgZdAkBhWNuyaYbuHXWK3iG9JCmXVeORchZnPB38JtnefQYz5oCSAAsXkYHWrzWUdA7BTeaK1bOELb3xmIhG5T54MF2slWBB\\\\\\\\\\\\\\\/gdfxJar0q1ODfH2jz5mCpzCrkaf27nsO\\\\\\\\\\\\\\\/KvA9uJNeef0AcMLznyPXKGsHlZ1Oq2iERRDTCNnoS0SvVW5YFt0qq8+ZWiJrLo5WdbTblO23XOsotonWqG1Msp04SIG3ZS28b3QQ2YcXnn7vHzeq7RlQlGkCVsuGI0VsoRpSYihxHnyBHab6KOeOTY6S8k4qDagfhFAjAKaSewnu40DXhwsFbs4iVVuEHLbo6BC1UsBSwJg3hCWg1KRtDz2ux8OR3UKTFY3E6B9RyT27DHBdrgP6cgz4vI7\\\\\\\\\\\\\\\/bizcvH8pJJk1zoAOj2AscYDM1oNgiuQpw5X9QQPCbJax4SQqOfqydplmmTQCd\\\\\\\\\\\\\\\/gk7kgJ7k4mi0EC83FI4xwbiJLX3viSJ86cLKZlCunQC3SqvAk8rgEhHPuubqMaweUZfi9jjDihz9zn5Dn5bq9NhnIcJJkeB48mr9oSiLVBBUsgvjCnFC39DCpBcYZ4Vb2JOAVlEdl84tspL+MqTvkUQQbtjWb\\\\\\\\\\\\\\\/4Cir2LTW0LCJBusr8SnFe\\\\\\\\\\\\\\\/TDjLTE3jz5mBIBLWe8fPuzwTpENBd0gGbI6Ah7gKGCZ0qWRDpqcv+0KSmugKT00j7D9PPKme7P9MCp+F7NnBKIkkCbyJWEOvH7u0YZDPBIuuMnJun8SoGovE50Su2ECIAsZqtWVeY3flJSu2jXnxvFB47b0QbyIo3zdr33Ms+m4Va4pAn0PsHmHSbtt8\\\\\\\\\\\\\\\/LUky7YDwCHDow69Or3WrdZPm4H7hFggYWy13Sb\\\\\\\\\\\\\\\/raBBfU6ImYu6bZdSZejsnu1bZEHiZgdrINEnPoojEESbmzFuoF6D0ocmVVeodwjC1tHkcxAl7CwKZYy91Ac3QecBTmTj5UMKZdIW31xWxBuuyVCCGcqESEL9p7QmLdMntoBtDpYAWJOaO6zfmpXsMs\\\\\\\\\\\\\\\/lxwJqimYQUWQo5wxcRc76Qj5tyj6LTtED8QoxRzLQO9\\\\\\\\\\\\\\\/hPgkyo42uVjELAJ7YA6GkZAM9p8OGZrsvI8D9j\\\\\\\\\\\\\\\/BXFswfgr2lAgNxuaLBZbC6kjPqwLyMEZCztfxmxrdWDpWaFJFeF0NC3AwF\\\\\\\\\\\\\\\/G0njlV6FfYiz7w6m0GBYxHnNf+Cp8FtsXHSXVPSrAhTIiNWDYN8\\\\\\\\\\\\\\\/70Tn7HEqOpJmEvqFYCSAaVz+R3uO5TEW\\\\\\\\\\\\\\\/oM9kXMMc58rt\\\\\\\\\\\\\\\/6PXaOYMNXLzVWr59U\\\\\\\\\\\\\\\/f6ucnrvhmGZv0Nmn51vsX987JFvbqKhVt69RMQ6gnMb+3n0c\\\\\\\\\\\\\\\/EMZ36XRJbeQGEljd7ny0tKTLrIBclO1TPRRcugrtJfAG1MhTIx\\\\\\\\\\\\\\\/QR6jZUnd+u5ZJZqKYAvGU7jOujtqq3QI0dM9hgQPK20TplPegdNpe0iYoQ4KhHw0rAq8Jq9\\\\\\\\\\\\\\\/nePufIHpy6jA+wAxZ7VT4L3feN4iSRIXeOvn1e\\\\\\\\\\\\\\\/XSDYH\\\\\\\\\\\\\\\/67GeblVGKifpqCgjZtv1jGVsjMMC+HQmM7a5z9sOmQ\\\\\\\\\\\\\\\/i3UweWfKOgTnQZSTUUOpWOFgbZzjMjSXgzbSJYpDNdaRpxIPnD1aOv2dTemkUilimEDgd3nGvDIZawsAonPmU6jreBRxcDfqhLRL\\\\\\\\\\\\\\\/faVo\\\\\\\\\\\\\\\/8E66LvdgWYydLSaEXonJKSQmfKKxmXu+\\\\\\\\\\\\\\\/4j38pzz3KXNr4B2ShiQuprSRO1J00i1k4av02+E4IqSeR7DHkvQ4cxeo134U2Ccvuuwxp5Mpk0jZbg8lVxRMKYIhniu6TBA\\\\\\\\\\\\\\\/ibWfi+ZDXtYTdzymOBNKMTMxk18HGtURFhpkUcJ9XywkM0283wVRorVeSRDENqAP27\\\\\\\\\\\\\\\/nWCsSamd0BQJk09qws9cw5zHrolzfM5hTd4Zh15mUA5dafMyTv2qqmI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022v8hOW689D0ZWl0SollvXIA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e1b3f0e904f1db5604adf9ee8b86d261b0ba09b2bcc9e9953037f594979b051c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e007268.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e007268.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007268\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007268\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007268\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}