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Immune cell therapies and immune cell engineering
Original research
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation

Authors

  • Jiri Eitler Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany PubMed articlesGoogle scholar articles
  • Wiebke Rackwitz Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Natalie Wotschel Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Venugopal Gudipati Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria PubMed articlesGoogle scholar articles
  • Nivedha Murali Shankar Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Anastasia Sidorenkova Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Johannes B Huppa Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria PubMed articlesGoogle scholar articles
  • Paola Ortiz-Montero Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Corinna Opitz Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Stephan R Künzel Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany PubMed articlesGoogle scholar articles
  • Susanne Michen TU Dresden, Medical Faculty and University Hospital Carl Gustav Carus, Department of Neurosurgery, Division of Experimental Neurosurgery and Tumor Immunology, Dresden, Germany PubMed articlesGoogle scholar articles
  • Achim Temme TU Dresden, Medical Faculty and University Hospital Carl Gustav Carus, Department of Neurosurgery, Division of Experimental Neurosurgery and Tumor Immunology, Dresden, GermanyGerman Cancer Consortium (DKTK), partner site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany, National Center for Tumor Diseases (NCT), Dresden, Germany PubMed articlesGoogle scholar articles
  • Liliana Rodrigues Loureiro Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany PubMed articlesGoogle scholar articles
  • Anja Feldmann German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, GermanyNational Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany PubMed articlesGoogle scholar articles
  • Michael Bachmann German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, GermanyNational Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany PubMed articlesGoogle scholar articles
  • Laurent Boissel ImmunityBio Inc, Culver City, California, USA PubMed articlesGoogle scholar articles
  • Hans Klingemann ImmunityBio Inc, Culver City, California, USA PubMed articlesGoogle scholar articles
  • Winfried S Wels Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, GermanyFrankfurt Cancer Institute, Goethe University, Frankfurt am Main, GermanyGerman Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, a partnership between DKFZ and University Hospital Frankfurt, Frankfurt am Main, Germany PubMed articlesGoogle scholar articles
  • Torsten Tonn Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, GermanyInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany PubMed articlesGoogle scholar articles

Citation

Eitler J, Rackwitz W, Wotschel N, et al
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
Journal for ImmunoTherapy of Cancer 2024;12:e008155. doi: 10.1136/jitc-2023-008155
Online issue publication 
February 27, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.