{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022xdm68Kav9fONdBnVjDc3bXhGhD6D2D07aKSgsOlFAmmx+YFk6Ifjo6\\\\\\\\\\\\\\\/b17q28QnGXkrUPiE4SCZmBptJJhLnpn3C1eUulhCDUaF3Q48l6xXvM+XrwMZnyVh1Vc8WM4c9eplWBPdCR33KGAnQK2OP0Vj5l5ckh+Uo3kIQWaLUclE85DMYb3jpG6nDjGI1ZDO2Z61Deegu8rbSx40e\\\\\\\\\\\\\\\/Gb4b5mtFcppHfrjf6jsFu2BdEZFSTgeVXHDExYMz6TIglnMyp0MBNOvqgwkbj5Q+RT0ZPwPed+R9ViBE8KrZgzxYKWtmdU0aJiCLFgYPPks9IYMUhyBlPWjUTXVZiNOlWjPOAhzVOIsZBSTfRzPTMkewFhik+1neqrBK2GBpXjn46eW7DWMxJrit5Y8Di4ySRTxG+DWsz7o4knD4mHbYVPZFE2\\\\\\\\\\\\\\\/EYk9rT4ElpLPj+JIdeBOL7rYPSXQ9ftwhlv610bdVDuwrIzl9F2K1h2CWBdqM5DUwtEI54Q2CnZexV9J\\\\\\\\\\\\\\\/8IGaEXkmJOqYP+K4x3\\\\\\\\\\\\\\\/RNaXPCd62484w2r6WZa7VDWHhgabdG5cM29dWOcqbdK1eP1RwAab32yO\\\\\\\\\\\\\\\/rvCqFDQHCpNWh18IOCdKia6TYW\\\\\\\\\\\\\\\/3THWsxG8Nc6Jqjlhhy5oE04kDmunlxm\\\\\\\\\\\\\\\/Ebnlsq+M8KOqxWVO\\\\\\\\\\\\\\\/063+6nHfYQ7c9QWSfmTfr7bWN2aMkwL5RYQHMH3BypkWJo184QAsQwzLb8bvvUxkTu\\\\\\\\\\\\\\\/KKSGGcMkSa2KS4PPUdd112yhcF3PiPXnCCTtDyEnIMiz+uD1og3XVTMlpdl82057D9B8d3VQPTikoGd6wKG+LUIP0UvoQzjbLuPD9feMCKX55689ShhmeacErxwYRueNNw4HAdKfGby0ZskNE4nYIsS0j+wY+4keHTKNDYd7q75qq34KENjmqj63GsWv37CHdE1RyXhNBJC3InZ+nDjRnKbXq96Sqc\\\\\\\\\\\\\\\/+BxvkG2F3XVOPjgjoZDUYYVxnKob21NI7iiBeL0zEwq892HdQbhRNkXdvoBCjaFfkmQz9NX+HtjvZ4HYv3qMP4VOlqUmZJprMrzE5\\\\\\\\\\\\\\\/QL8wsJpZ+R4HW8rMFzaN7xxQI+DYe688pvAoAk1jtJlJhgpPphP+HgWgkjG\\\\\\\\\\\\\\\/tj1IZQSSLQnY9qXv9lLo6Jw\\\\\\\\\\\\\\\/JwoG4o7G3aA6RKGT42\\\\\\\\\\\\\\\/qMv4cTqWMbbIVo8ksYU8OsYjKarPW7hBE8XIXD0QKZ7MOaJzn1w745XbLv\\\\\\\\\\\\\\\/1KPkc8pzXPfP+uLe6FJRdtQAymn7ES\\\\\\\\\\\\\\\/Iuu8Q6B5ULBkZivOprPIHxpEEdzG2vYiB0U5sFbjsC\\\\\\\\\\\\\\\/62ZIk6RKUfH0HoW5aQYOA2R9jPvLHBrHnQf3oZyQLv6m+2rJvEx64DOW+Pd2XSS40rhAxGt2eoUuvruQ3ZnMKGe+t3dDGTUvfBf\\\\\\\\\\\\\\\/8HDZ+Y8DM1bL\\\\\\\\\\\\\\\/7k3DejYW+GVK3VREVrEaAf1p6fMaRezV7tWIDI9mo0LkAElZNkcVtSeUeukbN8Ik4fnug9DvAk5e3zBi66Ata\\\\\\\\\\\\\\\/Iy3SmEGfOfFtkLWQJ4CTQYYP1z7msZj0WhKJfMd+vJXvQgbAwsl+IftKQIqmTqHM1yrSxmMYmCyW+5VD3YmZdZG88TVm+09U5LXXnSFkbNMrOOwqilSiGoPwAvaNcVsjjLbDMwcOTz2MwwKhQf78cXAHxKorS2PG7P6kolQ06RMkXoIYBmB5X4rWgL05xY9MeBYrKcS1c8XMalmolcbOu43bA+aNaL96elNaj0KC+TSZ0Tywpk\\\\\\\\\\\\\\\/ej0mLphQD6dM51tbG+wGUSH9x8U5vXmbMdH7EtbogsHDoutXSBIrnV0qiG6V5kJQ9O+6OIJ18gkT2j8JwkkxcjYlEnPQkz1koNdBpeFWVjC1C1iaPcqu54qOkPsTe6xQWMwd1WMqqhi0Vy4AiUIClJYH1jKHFv5uRmzQF61YEFTxBn4zdTfzdKFO+m5DaxJhTGvdlKG6LsPXs1TPNt1agD6JhCBpEvn\\\\\\\\\\\\\\\/S6SsQBVn5CqpaYdWVQTO6OBOyfAFyUN2TOTo7fPTSb2N2YBuq5ie1u1npfCkRGlOUlG8TQ7mRnHGCijhIVBFBW9OzXf4W9zFqe+agjbkB2pMAjtZHAwBE\\\\\\\\\\\\\\\/sO0IzlqxYtY7MReDv\\\\\\\\\\\\\\\/nZiuDhKjnS04LD5JHsXo9GVGs\\\\\\\\\\\\\\\/pZXj7rp2sLMS4WoOx+k8zzdiJA3IF5ysfrA+MIsazmGZwHgjEq\\\\\\\\\\\\\\\/4fr\\\\\\\\\\\\\\\/BZs0MpUKkHFrAGCvk12mv8b37H6HbkSgL3ZhRoOM0NIdmzxAPxrKETWWsXoGlTtcCb419TYjKf56Eh9S1fxO7qVhPVEbUwQjtenDim0ILyvFnZt6doJaSvvnOw\\\\\\\\\\\\\\\/iSzD2qiR2jsQpeGTnb3kqvw15LP7fya5quZQnjkjDfmUObw2YTEczfYaXbOqUbTkARz\\\\\\\\\\\\\\\/OJIjWPOWfN6L39lxMCE9gvN4pLwvfFmj8v2s0Q9+\\\\\\\\\\\\\\\/czhcj8zwCS0uAfww8PWokJbPflcc+HJesbEFGCqnu8C36P2H30v3H6D1GrAE4Ybd4jgZlM2d7EYkJtCfXvKT1YdhroOdd9ba3jiHln3WKXYb2lDWtzm4g2mlXm3T2LtaIsqphBjRVTYoTmvXTPG+CA0ifEl5eSvwwxosF4iUpfMWrhehiAPbt67pKOLcnH7GZEOEpbE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224QEqqJV1HhEpH\\\\\\\\\\\\\\\/pLJJd5Cg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222305a70779458ae05d560c057fe7f65bb0ae9945b94124077f9631d6a8be56a0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e008155.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e008155.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008155\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008155\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008155\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}