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  • Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma

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Immunotherapy biomarkers
Original research
Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma

Authors

  • Feng Zhang Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Wenfeng Liu Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Fansheng Meng Shanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Qiuyu Jiang Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Wenqing Tang Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Zhiyong Liu Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Xiahui Lin Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Ruyi Xue Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Si Zhang Shanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Ling Dong Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Liver Disease, Shanghai, ChinaShanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles

Citation

Zhang F, Liu W, Meng F, et al
Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma
Journal for ImmunoTherapy of Cancer 2024;12:e008094. doi: 10.1136/jitc-2023-008094
Online issue publication 
January 25, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.