Journal for ImmunoTherapy of Cancer: 12 (1)

Basic tumor immunology

Original research:
Sulforaphane activates CD8⁺ T cells antitumor response through IL-12RB2/MMP3/FasL-induced MDSCs apoptosis’
(31 January, 2024)
Jinyan Liu, Huanan Chen, Caijuan Guo, Jieyao Li, Miaomiao Li, Ming Zhao, Ziyi Fu, Zhen Zhang, Feng Li, Xuan Zhao, Li Yang, Liping Wang, Quanjun Lv, Yi Zhang
Original research: LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy (25 January, 2024)
Lingjuan Sun, Zhibo Ma, Xiangli Zhao, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Li Chen, Zhishui Chen, Gang Chen, Peixiang Lan
Original research: Multimodal profiling of chordoma immunity reveals distinct immune contextures (25 January, 2024)
Siddh van Oost, Debora M Meijer, Marieke E Ijsselsteijn, Jessica P Roelands, Brendy E M W van den Akker, Ruud van der Breggen, Inge H Briaire-de Bruijn, Manon van der Ploeg, Pauline M Wijers-Koster, Samuel B Polak, Wilco C Peul, Robert J P van der Wal, Noel F C C de Miranda, Judith V M G Bovee
Original research: Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites (11 January, 2024)
Tara Muijlwijk, Dennis N L M Nijenhuis, Sonja H Ganzevles, Arjen Brink, Changlin Ke, Joseph N Fass, Venkatesh Rajamanickam, C René Leemans, Yoshinobu Koguchi, Bernard A Fox, Jos B Poell, Ruud H Brakenhoff, Rieneke van de Ven

Case report

Multistep tumor genetic evolution and changes in immunogenicity trigger immune-mediated disease eradication in stage IV melanoma: lessons from a single case (4 January, 2024)
Viviana Vallacchi, Elisabetta Vergani, Mara Cossa, Chiara Gargiuli, Adele Busico, Andrea Devecchi, Matteo Dugo, Laura Bergamaschi, Loris De Cecco, Stefano Cavalieri, Barbara Valeri, Elena Tamborini, Gianfrancesco Gallino, Michele Del Vecchio, Mario Santinami, Marialuisa Sensi, Licia Rivoltini, Lorenza Di Guardo, Monica Rodolfo

Clinical/translational cancer immunotherapy

Original research: No detrimental association between antibiotic use and immune checkpoint inhibitor therapy: an observational cohort study comparing patients with ICI-treated and TKI-treated melanoma and NSCLC (31 January, 2024)
Marjolein Metselaar-Albers, Irma Meijerman, Ferdi Engels, John Haanen, Jos Beijnen, Arief Lalmohamed
Original research: Effects of antineoplastic and immunomodulating agents on postvaccination SARS-CoV-2 breakthrough infections, antibody response, and serological cytokine profile (31 January, 2024)
Jacob New, Jason Cham, Lana Smith, Leah Puglisi, Tridu Huynh, Sunil Kurian, Samantha Bagsic, Russel Fielding, Lee Hong, Priya Reddy, Ki Suk Eum, Allison Martin, Bethany Barrick, Christopher Marsh, Michael Quigley, Laura J Nicholson, Amitabh C Pandey
Original research: Management of infliximab refractory immune checkpoint inhibitor gastrointestinal toxicity: a multicenter case series (31 January, 2024)
Catriona Harvey, Kazi J Nahar, Janet McKeown, Serigne N Lo, Sheima Farag, Nadia Yousaf, Kate Young, Liselotte Tas, Aafke Meerveld-Eggink, Christian Blank, Austin Thomas, Jennifer McQuade, Bastian Schilling, Douglas B Johnson, Roberto Martín Huertas, Ana Arance, Joanna Lee, Lisa Zimmer, Georgina V Long, Matteo S Carlino, Yinghong Wang, Alexander Maxwell Menzies
Original research: Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer (30 January, 2024)
Kosaku Mimura, Takashi Ogata, Phuong H D Nguyen, Souvick Roy, Hassen Kared, Yate-Ching Yuan, Michael Fehlings, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima, Hisashi Sato, Nozomu Machida, Takanobu Yamada, Yohei Watanabe, Tomoaki Tamaki, Hirohito Fujikawa, Yasuhiro Inokuchi, Suguru Hayase, Hiroyuki Hanayama, Zenichiro Saze, Hiroyuki Katoh, Fumiaki Takahashi, Takashi Oshima, Ajay Goel, Alessandra Nardin, Yoshiyuki Suzuki, Koji Kono
Original research: A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer (30 January, 2024)
Pénélope Desroys du Roure, Laurie Lajoie, Aude Mallavialle, Lindsay B Alcaraz, Hanane Mansouri, Lise Fenou, Véronique Garambois, Lucie Rubio, Timothée David, Loïs Coenon, Florence Boissière-Michot, Marie-Christine Chateau, Giang Ngo, Marta Jarlier, Martin Villalba, Pierre Martineau, Valérie Laurent-Matha, Pascal Roger, Séverine Guiu, Thierry Chardès, Laurent Gros, Emmanuelle Liaudet-Coopman
Original research: Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders (25 January, 2024)
Brandon M Huffman, Harshabad Singh, Lestat R Ali, Nora Horick, S Jennifer Wang, Megan T Hoffman, Katherine A Metayer, Shayla Murray, Alexandra Bird, Thomas A Abrams, Leah H Biller, Jennifer A Chan, Jeffrey A Meyerhardt, Nadine J McCleary, Wolfram Goessling, Anuj K Patel, Jeffrey S Wisch, Matthew B Yurgelun, Kent Mouw, Brendan Reardon, Eliezer M Van Allen, Jessica A Zerillo, Jeffrey W Clark, Aparna Parikh, Robert J Mayer, Benjamin Schlechter, Kimmie Ng, Sunil Kumar, Catherine Del Vecchio Fitz, Charlotte Kuperwasser, Glenn J Hanna, Andrew L Coveler, Douglas A Rubinson, Emma L Welsh, Kathleen Pfaff, Scott Rodig, Stephanie K Dougan, James M Cleary
Original research: Cryoablation triggers type I interferon-dependent antitumor immunity and potentiates immunotherapy efficacy in lung cancer (25 January, 2024)
Chuanjia Gu, Xue Wang, Kaiyu Wang, Fangfang Xie, Luonan Chen, Hongbin Ji, Jiayuan Sun
Original research: Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers (24 January, 2024)
Jianfei Qian, Qiang Wang, Liuling Xiao, Wei Xiong, Miao Xian, Pan Su, Maojie Yang, Chuanchao Zhang, Yabo Li, Ling Zhong, Siddhartha Ganguly, Youli Zu, Qing Yi
Original research:
NKG2A⁺CD8⁺ T cells infiltration determines immunosuppressive contexture and inferior response to immunotherapy in clear cell renal cell carcinoma
(23 January, 2024)
Youqi Qiu, Li Liu, Wenbin Jiang, Ziyang Xu, Jiahao Wang, Siyuan Dai, Jianming Guo, Jiejie Xu
Original research: Ipilimumab and nivolumab combined with anthracycline-based chemotherapy in metastatic hormone receptor-positive breast cancer: a randomized phase 2b trial (19 January, 2024)
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Claire Quaghebeur, Bjørnar Gilje, Beate Boge, Andrea Gombos, Ragnhild Sørum Falk, Randi R. Mathiesen, Lars Julsrud, Øystein Garred, Hege G. Russnes, Ragnhild Reehorst Lereim, Sudhir Kumar Chauhan, Ole Christian Lingjærde, Claire Dunn, Bjørn Naume, Jon Amund Kyte
Original research: Evaluation of potential biomarkers for lenvatinib plus pembrolizumab among patients with advanced endometrial cancer: results from Study 111/KEYNOTE-146 (19 January, 2024)
Vicky Makker, Matthew H Taylor, Carol Aghajanian, Allen L Cohn, Marcia S Brose, Christopher Di Simone, Zhu Alexander Cao, Leah Suttner, Andrey Loboda, Razvan Cristescu, Petar Jelinic, Robert Orlowski, Lea Dutta, Junji Matsui, Corina E Dutcus, Yukinori Minoshima, Mark J Messing
Original research: Treatment-emergent antidrug antibodies related to PD-1, PD-L1, or CTLA-4 inhibitors across tumor types: a systematic review (18 January, 2024)
Peter Galle, Richard S Finn, Catherine Ruth Mitchell, Kerigo Ndirangu, Zahra Ramji, Gabrielle Sophie Redhead, David J Pinato
Original research: Comparison of efficacy discrepancy between early-phase clinical trials and phase III trials of PD-1/PD-L1 inhibitors (17 January, 2024)
Xiang Li, Yangzhong Zhou, Bing Xu, Yunhe Qin, Jiuliang Zhao, Mengtao Li, Jiachen Xu, Guanqiao Li
Original research: Reconstruction of unreported subgroup survival data with PD-L1-low expression in advanced/metastatic triple-negative breast cancer using innovative KMSubtraction workflow (11 January, 2024)
Yan Li, Xueyan Liang, Huijuan Li, Xiaoyu Chen
Original research: Short-course neoadjuvant radiotherapy combined with chemotherapy and toripalimab for locally advanced esophageal squamous cell carcinoma (SCALE-1): a single-arm phase Ib clinical trial (9 January, 2024)
Ning Jiang, Jingyuan Zhang, Zhen Guo, Yinan Wu, Lijun Zhao, Cheng Kong, Xue Song, Lingling Gu, Yang Zhao, Si Li, Xia He, Binhui Ren, Xiangzhi Zhu, Ming Jiang
Original research: Cell membrane-anchored and tumor-targeted IL-12 T-cell therapy destroys cancer-associated fibroblasts and disrupts extracellular matrix in heterogenous osteosarcoma xenograft models (9 January, 2024)
Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Zhiliang Jia, Dristhi Ragoonanan, Jian Wang, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li
Original research: Clearing soluble MIC reverses the impaired function of natural killer cells from patients with multiple myeloma (8 January, 2024)
Sojeong Kim, Haerim Chung, Jeong-Eun Kwak, Yu Ri Kim, Chung Hyun Park, Yeonhee Kim, June-Won Cheong, Jennifer Wu, Eui-Cheol Shin, Hyunsoo Cho, Jin Seok Kim
Original research: mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer (4 January, 2024)
No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M Oltz, Dongjun Chung, Zihai Li

Commentary

CARs are sharpening their weapons (31 January, 2024)
Alice Pievani, Marta Biondi, Sarah Tettamanti, Andrea Biondi, Gianpietro Dotti, Marta Serafini
Gasdermin-mediated pyroptosis confers anticancer immunity (11 January, 2024)
Wu Lin, Ben Lin, Quan Zhou, Lisong Teng

Immunotherapy biomarkers

Original research: Prognostic model for unresectable hepatocellular carcinoma treated with dual PD-1 and angiogenesis blockade therapy (30 January, 2024)
Zhiqiang Mo, Ling Lv, Qicong Mai, Qiao Li, Jian He, Tao Zhang, Jingwu Xu, Jiayan Fang, Ning Shi, Qing Gou, Xiaoming Chen, Jing Zhang, Wenhang Zhuang, Haosheng Jin
Original research: Association of a gene-expression subtype to outcome and treatment response in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab (30 January, 2024)
Mara Serena Serafini, Stefano Cavalieri, Lisa Licitra, Federico Pistore, Deborah Lenoci, Silvana Canevari, Mario Airoldi, Maria Cossu Rocca, Primoz Strojan, Cvetka Grasic Kuhar, Marco Merlano, Federica Perrone, Andrea Vingiani, Nerina Denaro, Francesco Perri, Athanassios Argiris, Cristina Gurizzan, Maria Grazia Ghi, Alessandra Cassano, Giacomo Allegrini, Paolo Bossi, Loris De Cecco
Original research: Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma (25 January, 2024)
Feng Zhang, Wenfeng Liu, Fansheng Meng, Qiuyu Jiang, Wenqing Tang, Zhiyong Liu, Xiahui Lin, Ruyi Xue, Si Zhang, Ling Dong
Original research:
Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4⁺ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma
(17 January, 2024)
Magdalena Kovacsovics-Bankowski, Johanna M Sweere, Connor P Healy, Natalia Sigal, Li-Chun Cheng, William D Chronister, Shane A Evans, John Marsiglio, Berit Gibson, Umang Swami, Alyssa Erickson-Wayman, Jordan P McPherson, Yoko S Derose, Annaleah Larson Eliason, Carlos O Medina, Ramji Srinivasan, Matthew H Spitzer, Ngan Nguyen, John Hyngstrom, Siwen Hu-Lieskovan
Original research: TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy (11 January, 2024)
Shixiang Wang, Yi Xiong, Yihao Zhang, Haitao Wang, Minjun Chen, Jianfeng Li, Peng Luo, Yung-Hung Luo, Markus Hecht, Benjamin Frey, Udo Gaipl, Xuejun Li, Qi Zhao, Hu Ma, Jian-Guo Zhou
Original research: Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancer (11 January, 2024)
Gulfem D Guler, Yuhong Ning, Ceyda Coruh, Giuliana P Mognol, Tierney Phillips, Maryam Nabiyouni, Kyle Hazen, Aaron Scott, Wayne Volkmuth, Samuel Levy
Original research:
CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value
(11 January, 2024)
Francesca Battaglin, Yasmine Baca, Joshua Millstein, Yan Yang, Joanne Xiu, Hiroyuki Arai, Jingyuan Wang, Fang-Shu Ou, Federico Innocenti, Shannon M Mumenthaler, Priya Jayachandran, Natsuko Kawanishi, Annika Lenz, Shivani Soni, Sandra Algaze, Wu Zhang, Taline Khoukaz, Evanthia Roussos Torres, Andreas Seeber, Jim P Abraham, Emil Lou, Philip A Philip, Benjamin A Weinberg, Anthony F Shields, Richard M Goldberg, John L Marshall, Alan P Venook, W Michael Korn, Heinz-Josef Lenz
Original research: Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and prognosis in cervical cancer (9 January, 2024)
Junyi Li, Yuanjie Cao, Yancheng Liu, Lu Yu, Zhen Zhang, Xiaofeng Wang, Hui Bai, Yuhan Zhang, Shaochuan Liu, Miaomiao Gao, Chenglu Lu, Chen Li, Yong Guan, Zhen Tao, Zhiqiang Wu, Jie Chen, Zhiyong Yuan
Original research: Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study (9 January, 2024)
Olaf Penack, Thomas Luft, Christophe Peczynski, Axel Benner, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Lucia López Corral, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Peter Dreger, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Grzegorz W Basak, Zinaida Peric

Immune cell therapies and immune cell engineering

Original research: PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity (31 January, 2024)
Emmanuelle Moraes Ribeiro, Kathy-Ann Secker, Ana-Maria Nitulescu, Rebekka Schairer, Hildegard Keppeler, Anton Wesle, Hannes Schmid, Anita Schmitt, Brigitte Neuber, Daniela Chmiest, Silvia Podavini, Melanie Märklin, Boris Klimovich, Michael Schmitt, Fulya Korkmaz, Claudia Lengerke, Corina Schneidawind, Dominik Schneidawind
Original research: Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy (8 January, 2024)
Natalie K. Horvat, Isaac Karpovsky, Maggie Phillips, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Jacklyn Hammons, Zaid Mahdi, Richard A. Moffitt, Chrystal M. Paulos, Gregory B. Lesinski
Original research: Adoptive transfer of CMV-specific TCR-T cells for the treatment of CMV infection after haploidentical hematopoietic stem cell transplantation (6 January, 2024)
Chao Ma, Peng Chen, Jishan Du, Lu Wang, Ning Lu, Jiaojun Sun, Xu Qilong, Yu Wang, Liping Dou, Dai-Hong Liu

Letter

Response to Yu and Fuhler et al
(19 January, 2024)
Patrick Tiongco Magahis, Steven B Maron, David Faleck, Monika Laszkowska
Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors
(19 January, 2024)
Bingting Yu, Maikel Peppelenbosch, Gwenny Fuhler

Oncolytic and local immunotherapy

Original research: Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity (31 January, 2024)
Quentin G Wright, Debottam Sinha, James W Wells, Ian H Frazer, Jazmina L Gonzalez Cruz, Graham Robert Leggatt
Original research:
Intratumoral administration of the immunologic adjuvant AS01_B in combination with autologous CD1c (BDCA-1)⁺/CD141 (BDCA-3)⁺ myeloid dendritic cells plus ipilimumab and intravenous nivolumab in patients with refractory advanced melanoma
(11 January, 2024)
Jens Tijtgat, Xenia Geeraerts, Anais Boisson, Latoya Stevens, Manon Vounckx, Iris Dirven, Julia Katharina Schwarze, Steven Raeymaeckers, Ramses Forsyth, Ivan Van Riet, Sandra Tuyaerts, Karen Willard-Gallo, Bart Neyns
Original research: RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment (11 January, 2024)
Yuan Meng, Haotian Liu, Haoran Zhu, Wanrong Zhang, Dong Sun, Xuefei Han, Ying Liu, Guangzuo Luo
Original research: VB-111 (ofranergene obadenovec) in combination with nivolumab in patients with microsatellite stable colorectal liver metastases: a single center, single arm, phase II trial (6 January, 2024)
Kelley Coffman-D'Annibale, Yuta Myojin, Cecilia Monge, Changqing Xie, Donna Mabry Hrones, Bradford J Wood, Elliot B Levy, David Kleiner, William Douglas Figg, Seth M Steinberg, Bernadette Redd, Tim F Greten

Position article and guidelines

Corticosteroid-resistant immune-related adverse events: a systematic review (17 January, 2024)
Eveline Daetwyler, Till Wallrabenstein, David König, Laura C Cappelli, Jarushka Naidoo, Alfred Zippelius, Heinz Läubli

Review

Tumor-draining lymph nodes: opportunities, challenges, and future directions in colorectal cancer immunotherapy (19 January, 2024)
Yao Wang, Tingting Zhu, Qi Shi, Guanghui Zhu, Siwei Zhu, Fenggang Hou
Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research (11 January, 2024)
Raphael Yip, Gaston Arnolda, Klay Lamprell, Bróna Nic Giolla Easpaig, Renuka Chittajallu, Geoff Delaney, Ian Olver, Winston Liauw, Jeffrey Braithwaite
Historical perspective and future directions: computational science in immuno-oncology (8 January, 2024)
Cora A Ricker, Kevin Meli, Eliezer M Van Allen

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Table of contents

January 2024 - Volume 12 - 1

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Letter

Oncolytic and local immunotherapy

Position article and guidelines

Review

Correction

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Table of contents

January 2024 - Volume 12 - 1

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Letter

Oncolytic and local immunotherapy

Position article and guidelines

Review

Correction