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Clinical/translational cancer immunotherapy
Original research
Comparison of efficacy discrepancy between early-phase clinical trials and phase III trials of PD-1/PD-L1 inhibitors

Authors

  • Xiang Li Vanke School of Public Health, Tsinghua University, Beijing, Beijing, ChinaSchool of Medicine, Tsinghua University, Beijing, Beijing, China PubMed articlesGoogle scholar articles
  • Yangzhong Zhou Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China, Beijing, China PubMed articlesGoogle scholar articles
  • Bing Xu Vanke School of Public Health, Tsinghua University, Beijing, Beijing, China PubMed articlesGoogle scholar articles
  • Yunhe Qin Pharmcube (Beijing) Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Jiuliang Zhao Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China, Beijing, China PubMed articlesGoogle scholar articles
  • Mengtao Li Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China, Beijing, China PubMed articlesGoogle scholar articles
  • Jiachen Xu Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China PubMed articlesGoogle scholar articles
  • Guanqiao Li Vanke School of Public Health, Tsinghua University, Beijing, Beijing, ChinaInstitute for Healthy China, Tsinghua University, Beijing, Beijing, China PubMed articlesGoogle scholar articles

Citation

Li X, Zhou Y, Xu B, et al
Comparison of efficacy discrepancy between early-phase clinical trials and phase III trials of PD-1/PD-L1 inhibitors
Journal for ImmunoTherapy of Cancer 2024;12:e007959. doi: 10.1136/jitc-2023-007959
Online issue publication 
January 17, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.