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Immune cell therapies and immune cell engineering
Original research
Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia

Authors

  • Shifaa M. Abdin Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyCenter for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Daniela Paasch Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyCenter for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Arnold Kloos Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Marco Carvalho Oliveira Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyCenter for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Mi-Sun Jang Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyCenter for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Mania Ackermann Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyFraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany PubMed articlesGoogle scholar articles
  • Andriana Stamopoulou Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Philipp J Mroch Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany PubMed articlesGoogle scholar articles
  • Christine S Falk Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Constantin S von Kaisenberg Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Axel Schambach Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, GermanyInstitute of Experimental Hematology, Hannover Medical School, Hannover, GermanyDivision of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Michael Heuser Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Thomas Moritz Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Gesine Hansen Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyRESIST, Cluster of Excellence, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Michael Morgan Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, GermanyInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Nico Lachmann Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, GermanyCenter for Translational and Regenerative Medicine, Hannover Medical School, Hannover, GermanyFraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, GermanyRESIST, Cluster of Excellence, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles

Citation

Abdin SM, Paasch D, Kloos A, et al
Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia
Journal for ImmunoTherapy of Cancer 2023;11:e007705. doi: 10.1136/jitc-2023-007705
Online issue publication 
December 22, 2023

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Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.