{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022w\\\\\\\\\\\\\\\/XX1SNSXNAEMcObZ44F33kw1eRlN1bP96KGkquQo0gdWxXRrdVPqNocFJQzEavtYQkjEfFP2tTTaOj7aO3rJ\\\\\\\\\\\\\\\/x5bkYz6gU2XliwwJxqdIC\\\\\\\\\\\\\\\/y9jv7yTVOgOPhLlTXl\\\\\\\\\\\\\\\/jJnk90Hb\\\\\\\\\\\\\\\/P3xyXZAXVgY+jOluZtD6GAc6Ufy4GTkd7sVsuGqZOkLuMnb82pOT\\\\\\\\\\\\\\\/oQT13ZUcBIFxjOgn1XylvBqCmdjDsyF2D5COqAWKim6GqcCCLqS\\\\\\\\\\\\\\\/8fbsEjQriq2SBrPe50VGVzEv6FNfEsbtQwjZmvW6clGx+8Dl6f0eFjO5j4UEfDjW2UkU7rL3+CrrGTMRPV\\\\\\\\\\\\\\\/WajAE9KL0kZ+VNul2ZSlTurodsQAuQtwROxhigzc9PcHoH8LLQrXrb2H97mLqxnkpIluPaJNNe5XeocoPx7\\\\\\\\\\\\\\\/o2fKfbICKucOU8HlrqFhGm+cCdEvqNGNrFSG6wb7\\\\\\\\\\\\\\\/8\\\\\\\\\\\\\\\/H4wQSQzY4BbJLSPBO\\\\\\\\\\\\\\\/75ynCx5Lev7\\\\\\\\\\\\\\\/GES5kPWL15z3PxKptDvFmZGZm+UN3C8T3G63\\\\\\\\\\\\\\\/d6Xq89OqJbjegt+ONOOR8HAvmy8D+P8Tnn51683h7q4kToPqyvYxEKvGu6eB\\\\\\\\\\\\\\\/LzKkBWmF+QWjFbyrHC\\\\\\\\\\\\\\\/sWCOtzyYR70ewa\\\\\\\\\\\\\\\/+KEubIFadjeKoDNJBeVAtlWMmDaot7rk+oTrqWx\\\\\\\\\\\\\\\/gsAVY6\\\\\\\\\\\\\\\/GKw6f45q2QVdhWHfzpb2jiH2b6f6gmaQamlVvbuQt18bGx0WstLmWagv0YVcSrUrkVmpV0AYInwGpMgYgmcr1gPpaCsdinbNfkeCseFs9kyguaapONFDsUHAvsqsvvyF41VQTQQgRaiBklOpdABxgszuCnwVAue7bCIUaBlBLHb0jL0LZQ3e0HO9bpqGpsQm1miwuNDI\\\\\\\\\\\\\\\/CibXoywEvvDLS7CltSBuB6Dl+TlpC\\\\\\\\\\\\\\\/QVklyQUKqWjsWYYgd4H2mLFxDRUSjXD7ZUYYvC4bXkM5VOO4pSlaWsa8OM18mfWS59gRqzkEuFH\\\\\\\\\\\\\\\/kUsRAeNX0uwjudrG0XvZQtptJuvJr7VQqAGGhkeoEJGeaM38hC21opPY1DI1LBTNqwzQMLO9Ub\\\\\\\\\\\\\\\/31XANA+XyLUEnmttooY\\\\\\\\\\\\\\\/Y8LsBjkElQKRezKUKIZ61YwOQurrIEAniYFJOiA3HnCGvyRZWgI8R+m3SD9IZR1ZMgiYJ9aRijchzgd+jfACO+2ui0J72L8dUeX1xvY20qxSRaCMpZpTujGeO4ws1rx8s2dBSUz18+7iC\\\\\\\\\\\\\\\/eMzzKKPozIow+tQPG82LoohuSkvXz8hbE0BTA4K6jp2cIhnEW+xlGyDmXSDy5n4DZmo6rvSRwPDLYo3KxEV4jA+WVb8immAen6BOMhTf5g4I2pGq0RqQI\\\\\\\\\\\\\\\/MsufXGQLdjCd3Q2+IA11WeWO8Xg6nMbGs2a1uKX\\\\\\\\\\\\\\\/BR7Xf0mjBWCxSgR53qwMgaFG5U1QYmdHNKW5IjINb\\\\\\\\\\\\\\\/Nhn+DeWodUN6xGRTSK4tP70rm0EPGUZjlK6r3MSaSQrUoiTZwJ2fTzbNWZfJp6i14WiALm6mflbyHz7Kg9kYK+4PNuo9pxaIyLxuKspFU2kbRegMBS2CdvuvLQxi+X1hGES8Vy9iJzffcvHT96GW4pYieGzvEtHmt7AcOgLOXp+vEEHTcCAv3+8vB4GLGyRFlPXWwzmUbG9wFBdx4f4DY0lR\\\\\\\\\\\\\\\/UgCOItcSTpOqDd7lH+RSnkNSe\\\\\\\\\\\\\\\/YjqctOSGrkUj0xk1Qd1gE2fOEj+9w7vnbNs8zqT9oFrf0T0IZf0CXHMQArRlYoWxP1EQso8fO62qYZW1kdWuE87Km5\\\\\\\\\\\\\\\/imp9pwu2VpJEmmuVpuiX7v\\\\\\\\\\\\\\\/Z7DxOKZXoDIv+Y9kImzbRz+6YLgdDFwRd8DGm6fo6WBUwFBne0t6kkn\\\\\\\\\\\\\\\/w8vovzh5RG\\\\\\\\\\\\\\\/2KrQb91AI7vA6VNf+AvMTztJjrxl4\\\\\\\\\\\\\\\/5+FSBHeacnVQKvrS71q7\\\\\\\\\\\\\\\/MAfYY+ToAI9ZW35tGH0ex3aWIlUZZtn\\\\\\\\\\\\\\\/QifKfzrqhUhIancHREfUkagQfCCIwryCLTlCFpoWOWsidp\\\\\\\\\\\\\\\/Nshp5L4fNLH7F9zj13\\\\\\\\\\\\\\\/uAM9THTOIwI5bMVTzQ\\\\\\\\\\\\\\\/u7bHeULaWFKTT5E1uORbZIAXfCOF7NHzfQsVSC6apUI2V2cmMszAcupzKKj52iPZ97sK1YKohC6SMQpdVSsU+T5pEvFns0vBI8uPFYZ7tgISKk6QqKuiZ+aXKeMoYC1MC6LogT49n9Pverh10BP6B72uC6nsNTpmWN8hgWo4G3anvXJ1xPRwi3rXsVFb4o1UYAfqRs8ZcWv8GuknmMcFvawwoTbN9j3l49r8G+GAbQaKv5eEaS2U5IoSYo6u8EzZAxysv7BLgj2SXUtnZ4KAanxiiiIfv4plnLXou6kddDUAvi+OGGmfPxCjAg4VeC\\\\\\\\\\\\\\\/nPLrAdrM8Lct2WuRW7PikX7unZV8YDB77c31SHb0PjtWJxNDi3gFaoWxsMCeeap9Dnp8hnL4GIzt3MljuF8F7Wo+1YL2fTAmDbDqbSgn9oH04FAEJSXwOJ2xXbb8WcTdAhk0oN0E\\\\\\\\\\\\\\\/42yNcRAuHkBauf\\\\\\\\\\\\\\\/Ca3cGqU0ucm1eorxx2\\\\\\\\\\\\\\\/C6erHprctD\\\\\\\\\\\\\\\/33s7sTsqlxCPonvSAO098Ww2qmeczYTEFaLyPkZfJuuJ7jvwuYn3rrFirvvJT6OVsZZ+7JdVDiJHsM7u23E\\\\\\\\\\\\\\\/3ciXzH\\\\\\\\\\\\\\\/duwIacR9pC3EVew=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022IwHiWv\\\\\\\\\\\\\\\/WCsvWldB98MWzaw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226e4297ac4c3908649d7d04aafaba811ade79240c797e6ea1afed03b3859cb23a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/12\\\/e007705.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/12\\\/e007705.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007705\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007705\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007705\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}