ISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response

Luana Guimaraes de Sousa; Kimal Rajapakshe; Jaime Rodriguez Canales; Renee L Chin; Lei Feng; Qi Wang; Tomas Z Barrese; Erminia Massarelli; William William; Faye M Johnson; Renata Ferrarotto; Ignacio Wistuba; Cristian Coarfa; Jack Lee; Jing Wang; Cornelis J M Melief; Michael A Curran; Bonnie S Glisson

doi:10.1136/jitc-2021-004232

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Clinical/translational cancer immunotherapy

ISA101 and nivolumab for HPV-16⁺ cancer: updated clinical efficacy and immune correlates of response

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Luana Guimaraes de Sousa The University of Texas MD Anderson Cancer Center Department of Thoracic Head and Neck Medical Oncology, Houston, Texas, USA PubMed articles Google scholar articles
Kimal Rajapakshe Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jaime Rodriguez Canales Translational Medicine, AstraZeneca, Gaithersburg, Maryland, USA PubMed articles Google scholar articles
Renee L Chin Department of Immunology and Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USADepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Lei Feng Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Qi Wang Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Tomas Z Barrese Grupo Fleury, Sao Paulo, Brazil PubMed articles Google scholar articles
Erminia Massarelli Medical Oncology, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
William William Departmento de Oncologia e Hematologia, Centro Oncológico BP Beneficência Portuguesa de São Paulo, Sao Paulo, Brazil PubMed articles Google scholar articles
Faye M Johnson The University of Texas MD Anderson Cancer Center Department of Thoracic Head and Neck Medical Oncology, Houston, Texas, USA PubMed articles Google scholar articles
Renata Ferrarotto The University of Texas MD Anderson Cancer Center Department of Thoracic Head and Neck Medical Oncology, Houston, Texas, USA PubMed articles Google scholar articles
Ignacio Wistuba Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Cristian Coarfa Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA PubMed articles Google scholar articles
Jack Lee Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jing Wang Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Cornelis J M Melief ISA Pharmaceuticals, Leiden, The Netherlands PubMed articles Google scholar articles
Michael A Curran Department of Immunology and Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USADepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Bonnie S Glisson The University of Texas MD Anderson Cancer Center Department of Thoracic Head and Neck Medical Oncology, Houston, Texas, USA PubMed articles Google scholar articles

Citation

Sousa LGD, Rajapakshe K, Rodriguez Canales J, et al

ISA101 and nivolumab for HPV-16⁺ cancer: updated clinical efficacy and immune correlates of response

Journal for ImmunoTherapy of Cancer 2022;10:e004232. doi: 10.1136/jitc-2021-004232

Online issue publication

October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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