{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DxvjPl1bOfSqeqoZLxImSbiss8BVETfpJXvpEq+4HmyVOBolC+E5LRqfWyX5DTda\\\\\\\\\\\\\\\/LtjETWnoVx\\\\\\\\\\\\\\\/eTwVIqgVCca30zm3eYpWoYkSrqlRiI1W3qWAo5CDYA7ntu2LBt1CU8Iuw8QqtnjVR98hssVgNnT9xd9Z473eW44IGhAwaiOs1tfEBnE8S0HQocP6T2TZ0fM3K87oKq5o53Vy1c9GJM6VuaNSCGXCK3UlawQQyn8m+JYnXAPaSnT4jdyNZsSEzYtKL5ww1WFKRuEiZKW0H13DXctae4jvbEkg\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/Y+RlmZAXkmISXkgYRsWwSfcBjsBEPukOYaQarbseCRe8RnILO1+9uG+zJbwXU7tH8XCd9RV1II1hFUlrrjmVkvi7bARKIZnedgRY1ziAo5UU0hcQIHG1isXMs0nSvuk1769oxQnIImoRbHRjjtzGojHPrTdbOkiRlWKnDswfJa\\\\\\\\\\\\\\\/pxHoseRWlJTzxDw3TOgP7OvhkTpgHfDjcY6T1+WXhDuZZOkV+jcQsEztvtDdPG0VmJjep1xT565lPNZUNV2lvcoXGtrYBVSwUGOSBu4ug16U+fnUL9lTmmBUMIm19FP4DlEa3nRg4pAp69SuFrXyYJhPWz7Xbz8Psghq2UD6pVaj7+\\\\\\\\\\\\\\\/U2d8vSBjVHT6VAcUwbi6pUtFpVagSeSV6ip743a6o+51x8qbV2NZxSmUF4M3XcoHZOizMiqtGMc06tnSuJUeG\\\\\\\\\\\\\\\/jAi8JTh\\\\\\\\\\\\\\\/0vNaJVl4o9z6B4sHW\\\\\\\\\\\\\\\/zmXx7pUQhugmdyrr1fLp5L3mWCAEZYRV7u65cUdBcI7LiQkZMskSG8++W6hYKGH\\\\\\\\\\\\\\\/Wt2XFQY8euZFYp6A9\\\\\\\\\\\\\\\/bGqoAKjexUNC7qsVxzxO2MQ\\\\\\\\\\\\\\\/pQk\\\\\\\\\\\\\\\/wAyS4iSMICFNdyhevk9P8vfnligf0Qei1aduOqYsUpe9wKLMThipV3+FYoYGZiIAum7AlcKJyQPThbzLOEDDk7+0RyJERTN9Yl4d4DnJ9yR4io3chznBb6X1ivkVofYmfty7id5iEenxMHVtXunvd8rkwYpQU\\\\\\\\\\\\\\\/jJxs5esL0CXUEv\\\\\\\\\\\\\\\/wgINE3AVZLyK46erjwsb1C+HcXmGT8HOwVoYKu3MSy7gcq2fFysMn6ZH\\\\\\\\\\\\\\\/tZcy6fPrV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/W8E78gX\\\\\\\\\\\\\\\/6ga0uNfziS2ewUybrDpKZlKxWmZsBzn3+vSfDxiMD0beI6uM81QKWneK68jCS3Aq4N1qVBUZGl9sMH8qW7sMkgQRccy16UO5ddNQTfvEzp\\\\\\\\\\\\\\\/Pi2TZ6zV5WnmgJgIE9D\\\\\\\\\\\\\\\/iIY4MJcbmS+1BF1FPV8RYd0FaBKCC8rHFo++9f5vLRwrxjtFnFawM+OMBPf\\\\\\\\\\\\\\\/vEeooGOnrRIH9S0ym92N3UBwSQAyeEnJvInkYn8ABWu87d+E6KPYtKiYppOJTL0rPXvaM9Um4KOQbvvORez1BI6ssJzToOD4CdmHke28NheRmgXrOhehg5RruUni4XwMEL8lVIrcpIhXV5tcQ8XNdj+kYMR39g\\\\\\\\\\\\\\\/gZrzkqOE7Z1GUAiGPmSwLPHNM72ndB9QTlP8v03PKEMfAlCv3RmEef4ptanI80TbQ+\\\\\\\\\\\\\\\/sHPaqaGQ3EIC4InSwQ\\\\\\\\\\\\\\\/0iUrKPcC7ZPGkfNglzcyMzRzrMnTll3bk9tOPeQ08HL3NoGk0u9yZ8eJ07JqjuQuLsdzRswVj9MguZ1B3YmJCXa5lH8jQgxIpCpcGY1jUIqy1tg6cWosORJHAyfRlBvf9kZeSrbzvbNVeMCqm5MVxwQY6w0yz5b7Bk4MlLOFl9NICI9r9\\\\\\\\\\\\\\\/iA1PW0zU+MycD3Jou\\\\\\\\\\\\\\\/UZM+ql+M58S0PIrBzVm7GA4sKCklKzcDA4dAgs2Nf2vefRBh\\\\\\\\\\\\\\\/3jCFOH3ZahpL3tKqOl8ODqGmx3fB7cSTXnvgmwAo63QSQQa4EjcFxDfP6weq1GySaMVWjbwzgZ2xvz0vhIRYWNI4cNv\\\\\\\\\\\\\\\/ERHeReU5sk26PnDiyWDYlQUCz8l7CkkeDaP0cVraTlesPViqYcYluAPj658roLz0zbVOXJwNdR1jzy9jluJrxMEqXtGE8kfFI59JJnDGYXdaUOGg5ff7+xtz\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/5ywMfghZbWGZVHx6CJErwbYmfqdX+W+BHxdBblOpblkkn7fOX9eT0n8p77C+Jt0XWuONKhlC3Mz+TnTS22YYbXCKByP4R3GI32emAODbMerJBLVG+712TSIcf9Y20kNCgtejrAoIuPhAMCvvRuzLXB4KjbWi0XzQYQh3KN19OBw1UB8\\\\\\\\\\\\\\\/5R2+bB8PKmz\\\\\\\\\\\\\\\/31bTyGaI8s5dCHk35b5oaBnMMizMtN5J4PiENHPaAtzpx\\\\\\\\\\\\\\\/1Pm1EfAbcHCVUyy9A7yvnfHROkdyl6VcT0ihlk7bSTkWr3DGCeIOxUYo12IWwjbWxD5900QGBYEpBJPGOY+yf3qUDmLcj1+ikc4CrDbpi5Pkmsb47kACGy9OAI8ZWf92kxvnctQEIJV\\\\\\\\\\\\\\\/fojf6hiLtSPDCyTBnQZnKR5JgTHrdMhltcb3BTmj8tVWw0rTgoFXnqBQYJlvHeLHqcXYAJZqjoQiQsPzqNFhMWAYKT8TMkSU8vcec4bFsR1mRfNkPBNzHN7o1BNdALe3yDVKzHQY\\\\\\\\\\\\\\\/Bjqv3C2PNqJc9aw8EACjY5BaEalmwQV2GXmD915K0bLowI1suojJOIT3N0aq0bVVa58DbrHJasGM+Z4YCxK5wE840=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JJRKty6z35PtKnlmOolVog==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f4e35f0786dc3b7029c434575e7ae954a4c66cd1860b82f6d4fe16c52ea84025\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e004232.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e004232.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004232\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004232\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004232\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}