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  • Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma

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Basic tumor immunology
Original research
Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma

Authors

  • Yu-Lu Peng Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Long-Bin Xiong Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zhao-Hui Zhou Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Kang Ning Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zhen Li Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Ze-Shen Wu Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, China PubMed articlesGoogle scholar articles
  • Min-Hua Deng Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Wen-Su Wei Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Ning Wang Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Xiang-Peng Zou Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zhi-Song He Department of Urology, Peking University First Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Ji-Wei Huang Department of Urology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China PubMed articlesGoogle scholar articles
  • Jun-Hang Luo Department of Urology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Jian-Ye Liu Department of Urology, Central South University Third Xiangya Hospital, Changsha, Hunan, China PubMed articlesGoogle scholar articles
  • Nan Jia Department of Nephrology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yun Cao State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaDepartment of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Hui Han Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Sheng-Jie Guo Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Pei Dong Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Chun-Ping Yu Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Fang-Jian Zhou Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zhi-Ling Zhang Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China PubMed articlesGoogle scholar articles

Citation

Peng Y, Xiong L, Zhou Z, et al
Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
Journal for ImmunoTherapy of Cancer 2022;10:e004206. doi: 10.1136/jitc-2021-004206
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.