{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bR1hSYf4VB\\\\\\\\\\\\\\\/d+owh+cgeR6cNtFtaa7uLrOaj3maLXVyFgqmpvZaZdhwTe9IjnUFeCg+vc8afPawqYBxaPuEKLH2uv02yA04kDcZgoGh+R4oUmczXe1fyTcwwSTCQ37zbovJUmtXaU5sgsqs1zjLvUosS259sRGMX702UzklnAGriDmfwP6px5RdZkywK+NCp2QvoZ1bilMtk2qJfBT6S15Ut1VrBsOzNnQC\\\\\\\\\\\\\\\/rTyYE9Gj+G7kO6k59o1PG8MXNOTB26cNoogCtMPY2UB3+9qM20X6gfay3yKV6DzV6MttS7wOvXKVs50F0nLE03TPu\\\\\\\\\\\\\\\/3E59VnnkuAu5GwvdempF+As1CdFYIRkPABUPROB2AXlSlXCiKSJCBvaZYIK2NfU1ufgLmDDMpKS5m3Fo4Tm4zX6id6LxtIIjBkF4h46w32SPhOYGSG0dMKpUQsZlcasjHNfqwhCLXL\\\\\\\\\\\\\\\/m07SoKhRiolEk+3EBy5VT0kT5SUvLzSOupJ1Ap8W+gN5DiFczHwz4vobD0gFYQUSaRX\\\\\\\\\\\\\\\/MVYIin0jRcFkacUTQcxSe9nk7dCNcH9NfQno77IopIkvQIWcpAKAl9gDEd+Vm5P1FYOMJTB5jDhhnhh1XG2w\\\\\\\\\\\\\\\/R5zEPTPJ9NdTNXujbKx1W5PmOUixxzqYuk8th2sa6cwWyKnqmwbV6lIbQT\\\\\\\\\\\\\\\/3cRnlTSK7Hkqz2btyKEqld8\\\\\\\\\\\\\\\/OIi5gdKysXRbcsIBgeg8CvX2n+qOqahkZmXSc+mjuyXHQA2pzk5a6n4tECL777snCeLkUm2zBBv4AwRQW7lJLyCDRNLeh3G3tC2da3AoH0r4kxgWRqCPoVHLqvz8QlNb+j3sAQfT1dblVTJRXSGEr4nAvctKp+ZPBLI2aT4Ljwz4cgZb9qshXHLbk5LdPF20hSYA75wSx9+w0cg8n5jzGd8mXHIgOFLGlVjlTJxrj6pTQIaO2AJKwNIHbmcPcTqIC9c8ThQ07ktLG6V7ze\\\\\\\\\\\\\\\/a7ePwR\\\\\\\\\\\\\\\/EQIFScJPQ3tr4scyvIvPBSM3kHlXI4Qjh2DmWuFd71VdZXONLxLdV1USCfkN3nRVAMv+S6xPh8sbq3SIgLeRYeTYco6IERnjQQuXaijfYNorA3cNc6YrrY+5V5FmroSgjW4VwWz4W6CmfWPcdj9TvPGGtwloNZPq8w0IN4EzSoBcenYEOhg0mwWIRI65U7yuXqO3+rEQlepV56eb0aQ\\\\\\\\\\\\\\\/R3iy1V\\\\\\\\\\\\\\\/R4fKjUByHuzcOV4G3ZUbPDusWVMZlSKxpMYpqyLWm5u72LZtQWgbK9+HcYUpr4sL6KwBTv9P069cCwHW5x8Z1WxfTDgvalSUDOL9HRMGYpELjep\\\\\\\\\\\\\\\/uLZKDukvvNQCnX7jdpk98BBWI+sfXl95CPA8O5IMz8KOcWmXUDYOuZJ0dh+FNy3hUo0jcVTMH9jA4Bx\\\\\\\\\\\\\\\/c1KrjX\\\\\\\\\\\\\\\/B+W79PgWc8NJv57SuwSmqIUXLJDZ4L7bos1BTesn3WnO8Kt6VuUYjg2Lagczc1wpJUQ3zIB8avSAt28OUffMb56cABXd7\\\\\\\\\\\\\\\/lriHcddDVbH\\\\\\\\\\\\\\\/+oTSx\\\\\\\\\\\\\\\/9blmHA\\\\\\\\\\\\\\\/17sVqg6JOhQ0QZrO9M3RUcFpMD4eNYNlFHqIi\\\\\\\\\\\\\\\/TcOFhFbL+\\\\\\\\\\\\\\\/IsSI5z4IbGPltQuikvoc\\\\\\\\\\\\\\\/QtRxQiObeBNOjMD6NQSB6eJ4DvPPI6nD99qInGwlIxTK70q\\\\\\\\\\\\\\\/zQ+eGxMf42CdZ5nMp2HAhhzOHPajsL6pnxgttP8STbGT767URJKMsX89mxZlmkbRh1nGppiodzAIN+zJJWITr9WYW9UGxG+6teFctWRju7YhgDUt6qhQeAgUoquvuUF8NR62RNBZKyN\\\\\\\\\\\\\\\/hWwtxRKREqHl5A6EwqJge9b0YEdrJtv5mPw2psuuUXyKR6eWQ7tcWyI4MYc3bSYlZs9AlGPIzWKgu3qrmYO4xkK6g5KAY7JB+z8lU9UrdcJCVFISUvc0kdIOJbirtmsQ5MwzDPcUg+6kj\\\\\\\\\\\\\\\/c3D4mfHK0ObSVddgZh1TJYCisdjvooy+JgBzRh00KqlMc0PpPD8WMB9UO7X+HGsfZJN5Al82oDy+KvdlsT2fl0l5FwJbrl\\\\\\\\\\\\\\\/LHcFQo+irxxuYyi7WXVMffUkG9pIN6JqdGTjY38Fhi9Y+H8Otoqyn4m6bYRJ3L0vyKTfMMTQ4KOvCYXSOz8EUjRhMPldektzE7hGzFo8MxJLEwsLtRRhrQOSc4q\\\\\\\\\\\\\\\/Md7dXNUQumlT82Qga1v4ZzuQlIOc5uKbdfTLMuozudyUrz7i2P39HslY7gX0o25984a3DdlHxVRfxWHAI3qwH3SUNzp39jCAxst6\\\\\\\\\\\\\\\/tcLhHi9cNNcUm1AlIRQXoOIoawBkMj9z1eInY8A\\\\\\\\\\\\\\\/Lvh4M5qlnffKFz4q4InGpH2RpuMeXYLS84OvFOShs2ZrJv1a9CCcpIMxUvhEUXR38TL61jKAYfIH7q7nwCnjezhGfQavPJ3OyF+3z6SSX0XcHHBRq+jnNR+BBUBJ\\\\\\\\\\\\\\\/bo1sGVQtYOgQE7gFSWiw3ghuflusu\\\\\\\\\\\\\\\/3UQFDsYq6KzfbSAODxKN8Yf6kq+AjliSvJ\\\\\\\\\\\\\\\/6HY8ACORJBvUqLDmSYlUOKGMs+bh+raAiZnQNs8A1yVirQiLn2lsuxUwBgJlLBIHVtlkamlFkX1heBtHH660YdD1Ic\\\\\\\\\\\\\\\/NQ3aLcH7IWIfjTtfB7zx7Z9QsuV6D6Z2UV0RmmhVLq2E\\\\\\\\\\\\\\\/7mDMJQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022onmn2dS6nGGvBm4sRd9VKg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222be8ae4ac9e1c492edbd0ec27485f8a1136a125296d8957ea7622fdaeb5df793\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e004206.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e004206.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004206\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004206\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004206\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}