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Research ArticleArticles

Alzheimer’s Disease: Longitudinal CT Studies of Ventricular Change

Mony J. de Leon, Ajax E. George, Barry Reisberg, Steven H. Ferris, Alan Kluger, Leonidas A. Stylopoulos, Jeffrey D. Miller, Mary Ellen La Regina, Clara Chen and Jacob Cohen
American Journal of Neuroradiology March 1989, 10 (2) 371-376;
Mony J. de Leon
1 Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.
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Ajax E. George
2 Department of Radiology, New York University Medical Center, New York, NY 10016.
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Barry Reisberg
1 Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.
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Steven H. Ferris
1 Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.
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Alan Kluger
1 Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.
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Leonidas A. Stylopoulos
2 Department of Radiology, New York University Medical Center, New York, NY 10016.
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Jeffrey D. Miller
2 Department of Radiology, New York University Medical Center, New York, NY 10016.
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Mary Ellen La Regina
2 Department of Radiology, New York University Medical Center, New York, NY 10016.
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Clara Chen
3 Department of Nuclear Medicine, Hospital of the Albert Einstein College of Medicine, Bronx, NY 10461.
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Jacob Cohen
4 Department of Psychology, New York University, New York, NY 10012.
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Abstract

A 3-year longitudinal study was conducted with 50 Alzheimer’s disease patients and 45 elderly control subjects. All study participants received an extensive evaluation that included brain CT at baseline and follow-up. Quantitation of ventricular size, using both linear and volume methods, revealed highly significant cross-sectional and longitudinal differences between the Alzheimer patients and control subjects. Specifically, the annual rate of change in ventricular volume was approximately 9% in the Alzheimer patients and approximately 2% in the controls. The presence of age-related white matter lesions had no effect on the clinical course of the patients or on the changes in ventricular size. Among the Alzheimer patients, the rate of clinical decline was strongly related to the rate of change in ventricular size. Baseline ventricular measurements were of no value in predicting the subsequent rate of clinical deterioration or ventricular enlargement.

The results suggest that changes in ventricular size closely reflect the clinical changes in Alzheimer patients.

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American Journal of Neuroradiology
Vol. 10, Issue 2
1 Mar 1989
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Cite this article
Mony J. de Leon, Ajax E. George, Barry Reisberg, Steven H. Ferris, Alan Kluger, Leonidas A. Stylopoulos, Jeffrey D. Miller, Mary Ellen La Regina, Clara Chen, Jacob Cohen
Alzheimer’s Disease: Longitudinal CT Studies of Ventricular Change
American Journal of Neuroradiology Mar 1989, 10 (2) 371-376;

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Alzheimer’s Disease: Longitudinal CT Studies of Ventricular Change
Mony J. de Leon, Ajax E. George, Barry Reisberg, Steven H. Ferris, Alan Kluger, Leonidas A. Stylopoulos, Jeffrey D. Miller, Mary Ellen La Regina, Clara Chen, Jacob Cohen
American Journal of Neuroradiology Mar 1989, 10 (2) 371-376;
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