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1147-A TNRX-257, a multifunctional LAG3 antagonist and conditional IL2R&Upsi;/ß partial agonist, is a novel immune stimulant with high dose tolerability in non-human primates
Margaret Karow, Natasha Del Cid, Rajesh Sharma, Jianying Dong, Christina Carnevale, Christen Buetz, Glenn Capodagli, Jayd Hannah, Pricilla Walter, Stephen Demarest

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1835; DOI: 10.1136/jitc-2023-SITC2023.1147-A
1147-B Encapsulation of IL-12 with an ultra pH-sensitive tumor delivery platform improves tolerability and promotes antitumor response in a preclinical model
Qingtai Su, Stephen Gutowski, Austin Burcham, Irina Kalashnikova, Bhargavi Allu, Zirong Chen, Kartik Krishnan, Ruolan Han, Jason B Miller, Tian Zhao

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1836; DOI: 10.1136/jitc-2023-SITC2023.1147-B
1147-C Urolithin-A promotes CD8⁺ T cell-mediated cancer immunosurveillance via FOXO1 activation
Pierpaolo Ginefra, Helen Carrasco Hope, Yi-Hsuan Chiang, Sophie Nutten, Stephanie Blum Sperisen, George Coukos, Nicola Vannini

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1837; DOI: 10.1136/jitc-2023-SITC2023.1147-C
1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile
Han K Kim, Justin Monnier, Chi-Ling Fu, Matthew Zhou, Jennifer E Melrose, Hung Dao, Paul D Ponath, Katelynn A McEachin, David T Omstead, Cindy Kreder, Stefan Chun, Ying Yueh Lee, Rachel Grgich, Tracey J Lin, Joshua A Walker, Karla A Henning, Romas Kudirka, Shelley E Ackerman, Diane Carrera, Steven J Chapin, William Mallet, Dowdy Jackson, Changshou Gao, Michael N Alonso

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1838; DOI: 10.1136/jitc-2023-SITC2023.1147-D
1147-E UI-101, a TLR7/8 agonist encapsulated in cholesteryl pullulan nanoparticle targeting tumor-associated macrophages via binding to DC-SIGN, elicits potent anti-tumor immunity without severe side effect
Ayaka Matsumoto, Tadashi Inoue, Yasunari Haseda, Nami Mizoguchi, Junki Tashiro, Yuka Igarashi, Takatoshi Soga, Naozumi Harada

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1839; DOI: 10.1136/jitc-2023-SITC2023.1147-E
1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins
Amaia V Bermejo, Isabella Skandorff, Lasse Neukirch, Jasmin Gille, Frederik O Bagger, Karen N Nielsen, Joana Daradoumis, Charlie R Ince, Lara Duvnjak, Mikkel D Müller, Silke Schrödel, Louise Turner, Kaare Grunddal, Per thor Straten, Kristoffer Staahl Rohrberg, Christian Thirion, Ralf Wagner, Anne-Marie Andersson, Emeline Ragonnaud, Peter Holst

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1840-A1841; DOI: 10.1136/jitc-2023-SITC2023.1147-F
1147-G ERV-derived peptides as novel immunotherapeutic targets in ovarian cancer
Ines Mota, Laura Santambrogio

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1842; DOI: 10.1136/jitc-2023-SITC2023.1147-G
1147-H Novel immunotherapy regiment approach for pancreatic ductal adenocarcinoma (PDCA) using human MUC1 transgenic mice (MUC1.tg) model: optimizing conditions for MVA vaccine evaluation
Larissa Silva, Sreenivasa Oruganti, Manuel Rodriguez Cardona, Pinku Mukherjee

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1843-A1844; DOI: 10.1136/jitc-2023-SITC2023.1147-H
1147-I Endogenously high omega-3 fatty acids promote cross-presentation and improve dendritic cell-based cancer vaccine efficacy
Shweta Tiwary, Xia Zheng, Noriko Seishima, Kevin Hsu, Jay Berzofsky

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1845; DOI: 10.1136/jitc-2023-SITC2023.1147-I
1201-A An antibody-drug conjugate selectively targeting a GSTA glycosite-signature neoantigen epitope of MUC1 in cancer cells with COSMC deficiency
Yue Ma, Yu He, Hua Zhu, Patrick Hwu, Dapeng Zhou

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 2) A1846; DOI: 10.1136/jitc-2023-SITC2023.1201-A

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