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531 AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies
Lucila Kerbauy, Nancy Marin, Mecit Kaplan, Pinaki Banerjee, Melissa Berrien-Elliott, Michelle Becker-Hapak, Rafet Basar, Mark Foster, Luciana Garcia Melo, Carly Neal, Ethan McClain, May Daher, Ana Karen Nunez Cortes, Sweta Desai, Francesca Wei Inng Lim, Mayela Carolina Mendt, Timothy Schappe, Li Li, Hila Shaim, Mayra Hernandez Sanabria, Pamela Wong, Enli Liu, Sonny Ang, Rong Cai, Vandana Nandivada, Vakul Mohanty, Yifei Shen, Natalia Baran, Natalie Fowlkes, Ken Chen, Luis Muniz-Feliciano, Joachim Koch, Martin Treder, Wolfgang Fischer, Oswaldo Keith Okamoto, Yago Nieto, Richard Champlin, Elizabeth Shpall, Todd Fehniger, Katy Rezvani

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A324-A325; DOI: 10.1136/jitc-2020-SITC2020.0531
541 Investigating myeloid derived suppressor cells (MDSCs) and oligonucleotide based targeting of STAT3 in renal cell carcinoma
Marice Alcantara, Dayson Moreira, Chia-Yang Hung, Chunsong, Dongfang Wang, JoAnn Hsu, Sumanta Pal, Marcin Kortylewski

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A329; DOI: 10.1136/jitc-2020-SITC2020.0541
544 Multiomic characterization of T-cell populations at the single-cell level utilizing sensitive dextramers and BD® AbSeq on the BD RhapsodyTM Single-Cell Analysis system
Kivin Jacobsen, Cynthia Sakofsky, Vadir Lopez-Salmeron, Margaret Nakamoto, Liselotte Brix, Stefanie Mortimer, Kivin Jacobsen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A331; DOI: 10.1136/jitc-2020-SITC2020.0544
548 CD8+ tissue-resident memory T cells are tumour reactive and increase after immunotherapy in a case of metastatic mucosal melanoma
Angela Pizzolla, Simon Keam, Ismael Vergara, Franco Caramia, Minyu Wang, Nikolce Kocovski, ThuNgoc Nguyen, Sean Macdonald, Daniela Tantalo, Pasquale Petrone, Han Xian Aw Yeang, David Gyorki, Alison Weppler, George Au-Yeung, Shahneen Sandhu, Maurizio Perdicchio, Grant McArthur, Tony Papenfuss, Paul Neeson

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A333; DOI: 10.1136/jitc-2020-SITC2020.0548
552 SUMOylation inhibitor TAK-981 activates NK cells and macrophages via Type I interferon signaling and shows synergistic activity in combination with rituximab and daratumumab in preclinical models
Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Yuhong Zhang, Allison Berger, Allison Berger, Gary Shapiro, Dennis Huszar

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A334-A335; DOI: 10.1136/jitc-2020-SITC2020.0552
557 Determining the efficacy of ADCC by the 3D-EX ex vivo platform utilizing tumoroids of fresh patient tumor samples with intact tumor microenvironment
Jenny Kreahling, Jared Ehrhart, Stephen Iwanowycz, Mibel Pabon, Tina Pastoor, Soner Altiok

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A336; DOI: 10.1136/jitc-2020-SITC2020.0557
562 SO-C101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity
Zuzana Antosova, Nada Podzimkova, Marketa Jiratova, Eva Nedvedova, Guy de Martynoff, David Bechard, Ulrich Moebius, Radek Spisek, Irena Adkins

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A339; DOI: 10.1136/jitc-2020-SITC2020.0562
565 A novel long-acting interleukin-7 agonist, NT-I7, increases cytotoxic CD8+ T cells and enhances survival in mouse glioma models
Subhajit Ghosh, Ran Yan, Sukrutha Thotala, Arijita Jash, Anita Mahadevan, Tong Hu, Byung Lee, Se Hwan Yang, Dennis Hallahan, Milan Chheda, Dinesh Thotala, Jian Campian

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A340; DOI: 10.1136/jitc-2020-SITC2020.0565
570 IL-15/IL-15Rα heterodimeric complex as cancer immunotherapy in murine breast cancer models
Siqi Guo, Ronald Smeltz Smeltz, Anthony Nanajian, Richard Heller

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A343; DOI: 10.1136/jitc-2020-SITC2020.0570
574 ONM-400, a novel approach for interleukin-2 therapy using a ph-activated nanoparticle targeting metabolic acidosis in solid cancers
Xinliang Ding, Jason Miller, Qingtai Su, Stephen Gutowski, Ashley Campbell, Drew Robinson, Tian Zhao

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A345; DOI: 10.1136/jitc-2020-SITC2020.0574

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