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366 A randomized double-blind placebo-controlled phase III study evaluating perioperative toripalimab combined with platinum-based doublet chemotherapy in resectable stage III NSCLC
Wenxiang Wang, Lin Wu, Wei Zhang, Shun Lu, Haohui Fang, Guohua Yu, Ming Zhou, Wenqun Xing, Qixun Chen, Xingya Li, Nong Yang, Minhua Ye, Wentao Fang, Yunchao Huang, Jichun Liu, Lijie Tan, Xiaosheng Hang, Wengang Zhang, Liwei Zhang, Jun Chen, Xun Zhang, Yu Zhang, Jie Jiang, Aihong Zhong, Shanqing Li, Yunpeng Liu, Guowu Wu, Xiaoyan Kang, Ying Tian, Tao Xu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A223-A224; DOI: 10.1136/jitc-2020-SITC2020.0366
369 Safety and pharmacodynamic activity of ATOR-1015, a CTLA-4 x OX40 bispecific antibody, in a phase 1 dose escalation study of patients with advanced solid malignancies
Jeffrey Yachnin, Gustav Ullenhag, Ana Carneiro, Dorte Nielsen, Kristoffer Staal Rohrberg, Anne Månsson Kvarnhammar, Lena Schultz, Erika Bågeman, Erika Bågeman, Camilla Wennersten, Charlotte Russell, Charlotte Russell

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A225; DOI: 10.1136/jitc-2020-SITC2020.0369
383 First-in-man clinical trial of intratumoral injection of clostridium Novyi-NT spores in combination with pembrolizumab in patients with treatment-refractory advanced solid tumors
Filip Janku, Siqing Fu, Ravi Murthy, Daniel Karp, David Hong, Apostolia Tsimberidou, Maura Gillison, Abha Adat, Anjali Raina, Greg Call, Brent Kreider, David Tung, Mary Varterasian, Khashayarsha Khazaie

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A233; DOI: 10.1136/jitc-2020-SITC2020.0383
389 Combining transcriptomic- and tissue-based immune biomarkers to evaluate GB1275, a CD11b modulator, as a single agent or with pembrolizumab in patients with advanced solid tumors
Wells Messersmith, Drew Rasco, Johann De Bono, Andrea Wang-Gillam, Wungki Park, David Nickle, Anna Galkin, Beatrice Ferguson, Laura Carter, Lei Zhou, Jakob Dupont, Marya Chaney, Johanna Bendell, Jean-Marie Bruey

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A236-A237; DOI: 10.1136/jitc-2020-SITC2020.0389
388 Preliminary results from KEYNOTE-A36, a study of GB1275, a first-in-class oral CD11b modulator, alone and with pembrolizumab or chemotherapy in specified advanced solid tumors
Johanna Bendell, Wells Messersmith, Drew Rasco, Andrea Wang-Gillam, Wungki Park, Lei Zhou, Laura Carter, Jean-Marie Bruey, Jack Li, Beatrice Ferguson, Jakob Dupont, Marya Chaney, Johann De Bono

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A236; DOI: 10.1136/jitc-2020-SITC2020.0388
399 Cosibelimab, an anti-PD-L1 antibody: preliminary safety and efficacy results from a global, multicohort phase 1 clinical trial
Dean Harris, Daniel Brungs, Rahul Ladwah, Andrew Mant, Margaret McGrath, Andrea Tazbirkova, Andrey Akopov, Natalia Fadeeva, Boris Kasparov, Nadezhda Kovalenko, Vadim Kozlov, Fedor Moiseenko, Vasiliy Oschepkov, Piotr Koralewski, Dariusz Kowalski, Iwona Lugowska, Chaiyut Charoentumn, Arunee Dechaphunkul, Virote Sriuranpong, James Oliviero, Philip Clingan

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A242-A243; DOI: 10.1136/jitc-2020-SITC2020.0399
43 Highly multiplexed digital spatial profiling of the tumor microenvironment of non-small-cell lung cancer (NSCLC)
Arutha Kulasinghe, Connor O’Leary, Rahul Ladwa, Majid Warkiani, Kenneth O’byrne

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A26; DOI: 10.1136/jitc-2020-SITC2020.0043
484 Bioturing browser: interactively explore public single cell sequencing data
Son Pham, Tri Le, Tan Phan, Minh Pham, Huy Nguyen, Loc Lam, Nam Phung, Tuan Tran, Duy Phung, Thang Tran, Hoa Pham, Khoa Nguyen, Ha-An Nguyen, Trang Nguyen, Tam Luu, Hao Tran

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A299; DOI: 10.1136/jitc-2020-SITC2020.0484
5 Multiple myeloma flow cytometry panel validated for clinical monitoring of patients
Bevan Gang, Vicky Sgouroudis, Virginia Litwin, Anita Boyapati

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A3; DOI: 10.1136/jitc-2020-SITC2020.0005
485 RAFT: A framework to support rapid and reproducible immuno-oncology analyses
Steven Vensko, Benjamin Vincent, Dante Bortone

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A300; DOI: 10.1136/jitc-2020-SITC2020.0485

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