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226 Checkpoint blockade hastens a switch from an NKT dominant, TNF-alpha-driven to a CD4+/CD8+ IFN-gamma-driven immune response within MC-38 tumor-infiltrating lymphocytes
Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez Villarroel, James Mulé, Adam Mailloux

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A134-A135; DOI: 10.1136/jitc-2020-SITC2020.0226
232 The epithelial-to-mesenchymal transition (EMT) contributes to immunosuppression in breast carcinomas and regulates their response to immune checkpoint blockade
Anushka Dongre, Robert Weinberg, Mohammad Rashidian, Elinor Eaton, Ferenc Reinhardt, Prat Thiru, Maria Zagorulya, Sunita Nepal, Tuba Banaz, Anna Martner, Stefani Spranger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A138-A139; DOI: 10.1136/jitc-2020-SITC2020.0232
233 Gene expression analysis of immune checkpoint therapy in mouse tumor models reveals similarities and differences in immune cell populations and functional processes that reflect response to treatment
Dominic Pearce, Daniel Halligan, Patrick Fadden, Chassidy Hall, Amber Blackwell, Edgar Wood

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A139; DOI: 10.1136/jitc-2020-SITC2020.0233
26 ctDNA clearance and radiographic resolution of lymph node metastasis in a patient with metastatic microsatellite stable colorectal cancer on immunotherapy
Charles Schneider, Michael Krainock, Meenakshi Malhotra, Paul Billings, Alexey Aleshin

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A14-A15; DOI: 10.1136/jitc-2020-SITC2020.0026
236 Evaluation of PD-L1 expression in primary lung tumor and metastatic lymph nodes in the presence of immune cells
Chris Hansis, Xiaomei Wang, Tao Wang, Gerald Feldman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A140; DOI: 10.1136/jitc-2020-SITC2020.0236
237 In vitro potency assays for immune checkpoint blockade using human primary cells, murine huGEMM immune cells and patient-derived tumor organoids
Xuefei Yan, Hongjuan Zhang, Jun Zhou, Jia Zheng, Shuang Zhu, Rui Zhang, Mingfa Zang, Annie Xiaoyu An, Xiaoxi Xu, Shuzong Wang, Kevin Qijin Xu, Davy Xuesong Ouang, Henry Li, Yujun Huang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A141; DOI: 10.1136/jitc-2020-SITC2020.0237
268 A phase 1 study of retifanlimab (INCMGA00012), a PD-1 inhibitor, in patients with advanced solid tumors: preliminary results in recurrent MSI-high or dMMR endometrial cancer (POD1UM-101)
Dominique Berton-Rigaud, Ignace Vergote, Patricia Pautier, Anna Kryzhanivska, Antoine Angelergues, Deanna Kornacki, Monika Dudzisz-Sledz, Chuan Tian, Nawel Bourayou, Frederic Selle

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A164-A165; DOI: 10.1136/jitc-2020-SITC2020.0268
269 Tumoral and peripheral landscape of Viral- versus Carcinogen-Driven Head and Neck Cancer
Tze Heng Tan, Sriram Sridhar, Helen Angell, Emma Jones, Amelia Raymond, Sophie Willis, Dimitris Polychronopoulos, Alejandro Yovine, Nassim Morsli, Patricia McCoon, Carl Barrett, Maria Ascierto

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A165-A166; DOI: 10.1136/jitc-2020-SITC2020.0269
271 Consistent high-quality dendritic cell vaccines produced post-chemotherapy in patients with acute myeloid leukemia for use in a Phase I/II trial
Frauke Schnorfeil, Christiane Geiger, Iris Bigalke, Dag Josefsen, Yngvar Floisand, Gunnar Kvalheim, Dolores Schendel, Anna Tafuri, Kai Pinkernell

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A166; DOI: 10.1136/jitc-2020-SITC2020.0271
278 Phase I clinical trial evaluating the safety of ADP-A2M10 SPEAR T-cells in patients with MAGE-A10⁺ advanced non-small cell lung cancer
George Blumenschein, Siddhartha Devarakonda, Melissa Johnson, Victor Moreno, Justin Gainor, Martin Edelman, John Heymach, Ramaswamy Govindan, Carlos Bachier, Bernard Doger de Spéville, Matthew Frigault, Anthony Olszanski, Vincent Lam, Natalie Hyland, Jean-Marc Navenot, Svetlana Fayngerts, Jane Bai, Elliot Norry, Paula Fracasso

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A169-A170; DOI: 10.1136/jitc-2020-SITC2020.0278

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