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229 Large-scale omics profiling reveals type-2 functionality sustaining 8-year leukemia remission following CAR T cell therapy
Zhiliang Bai, Bing Feng, Susan McClory, Caroline Diorio, Ziran Zhao, Li Tang, Jan Melenhorst, Carl H June, Stephan Grupp, Rong Fan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A261-A264; DOI: 10.1136/jitc-2023-SITC2023.0229
230 ONCT-808 ROR1 CAR T cells induce significant cancer cell death in mantle cell lymphoma cell line-derived CDX models and in vitro killing assays
Shuguang Bi, Gunnar Kaufmann, James Breitmeyer, Rajesh Krishnan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A265; DOI: 10.1136/jitc-2023-SITC2023.0230
231 Differential effects of target ligands and receptor architecture upon NKG2D CAR T cell activation
Jennifer Bolsee, Caroline Lonez, Benjamin Violle, Sophie Agaugue, Thuy Nguyen, Jerome Marijsse, Eytan Breman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A266; DOI: 10.1136/jitc-2023-SITC2023.0231
232 NKG2D-based multi-specific CAR T-cells to overcome antigen escape and improve anti-tumor efficacy
Jennifer Bolsée, Benjamin Violle, Céline Jacques-Hespel, Jérôme Marijsse, Eytan Breman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A267; DOI: 10.1136/jitc-2023-SITC2023.0232
233 Repolarizing M2 to M1 macrophages using chimeric antigen receptors (CAR) for solid tumors
Michael Boyer, Michelle Townsend, Timothy Phares, Adam Blaszczak, Rachel Garlick, Kenneth Katschke, Gaju Shrestha, Ashlin Cowger, Rachel Morris, Taylor Brindley, McCall Jensen, Audrey Meade, Tony Mortimer, Kim O’Neill

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A268; DOI: 10.1136/jitc-2023-SITC2023.0233
234 Metabolic enhancement of alternately co-stimulated CART cells through AMPK creates functionally distinct phenotypes
Erica Braverman, Mengtao Qin, Herbert Schuler, Craig Byersdorfer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A269-A270; DOI: 10.1136/jitc-2023-SITC2023.0234
235 Preclinical evaluation and anti-tumor activity of AZD6422, a CLDN18.2 targeting armored CAR-T for gastric, esophageal and pancreatic cancers
Zachary Britton, Shannon Breen, Rosa Carrasco, Benjamin Clark, Maria AS Broggi, Jean-Martin Lapointe, Nicolas Giraldo, Bala NN Rao Attili, Amy Hatke, Christina Grigoriadou, Melissa Damschroder, Mark Cobbold, Emily Bosco, Gordon Moody, Allison Barrett

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A271; DOI: 10.1136/jitc-2023-SITC2023.0235
236 In vivo-generated TagCAR T cells inhibit solid tumor growth following treatment with bispecific small molecule TumorTags
Cj Cambier, Nanda Coelho, Alyssa Sheih, Anna Ting, Kelsey Lynch, Kristen Mittelsteadt, Suilan Zheng, Jeff Teoh, Phillip Low, Ryan Larson, Andrew Scharenberg, Byoung Ryu, Laurie Beitz, Haiyan Chu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A272; DOI: 10.1136/jitc-2023-SITC2023.0236
237 Epitope engineered hematopoietic stem cells to enable multi-specificity CAR-T cells for acute myeloid leukemia
Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed S Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Denise Klatt, Christian Brendel, Jerome Ritz, Scott Ficarro, Jarrod Marto, Danilo Pellin, Daniel Bauer, Scott A Armstrong, Pietro Genovese

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A273; DOI: 10.1136/jitc-2023-SITC2023.0237
238 Potentiating CAR T cell therapy through synthetic IL-9R signaling
Sofia Castelli, Ugur Uslu, Amanda Finck, Tong Da, Charles-Antoine Assenmacher, Mikko Siurala, Regina M Young, Carl H June

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A274; DOI: 10.1136/jitc-2023-SITC2023.0238

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