497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice
Alastair Corbin, Barbara Cipriani, David Miller, Alan Naylor, Gavin Milne, Barbara Young, Rupert Satchell, Mussa Quareshy, Sourav Sarkar, Tobias Moechel, Philip MacFaul, Stuart Paine, Oliver Horne, Jessica Holien, Anastasia Nika, Preeti Singh, Gavin Knox, Darryl Turner, Toszka Bohn, Tobias Bopp, Tom McCarthy, Stuart Hughes
Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A559; DOI: 10.1136/jitc-2023-SITC2023.0497
