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525 Investigating dynamic IDO-Kyn-AhR pathway-induced tumor immunosuppression using imaging modality to optimize AhR therapeutic intervention
Mamadou A Bah, Inna Serganova, Sadna Budhu, Jonathan F Khan, Jedd D Wolchok, Taha Merghoub

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A591; DOI: 10.1136/jitc-2023-SITC2023.0525
526 Robust prediction of patient outcomes with immune checkpoint blockade therapy for cancer using common clinical, pathologic, and genomic features
Tiangen Chang, Yingying Cao, Hannah Sfreddo, Saugato R Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc Morris, Eytan Ruppin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A592-A597; DOI: 10.1136/jitc-2023-SITC2023.0526
527 Clonal hematopoiesis is associated with reduced response to immune checkpoint inhibitors in lung cancer
Vylyny Chat, Minu K Srivastava, Barzin Nabet, Ira Mellman, Mark McCarthy, Christian Hammer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A598-A599; DOI: 10.1136/jitc-2023-SITC2023.0527
528 Activated T cells engage IL-1 and TNFa-driven tumor inflammation to support immune checkpoint inhibitor resistance in inflammatory solid malignancies
Nam Woo Cho, Sophia M Guldberg, Barzin Y Nabet, Eun Ji Kim, Kamir J Hiam-Galvez, Jacqueline L Yee, Rachel DeBarge, Katherine Wai, Lauren S Levine, Naa Asheley Ashitey, Matthew H Spitzer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A600; DOI: 10.1136/jitc-2023-SITC2023.0528
529 Impact of histology and PD-L1 status on immune checkpoint inhibitors in the treatment of non-small cell lung cancer
Khalil Choucair, Hyejong Jang, Shadia I Jalal, Tarik Hadid, Dipesh Uprety, Seongho Kim, Hirva Mamdani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A601-A602; DOI: 10.1136/jitc-2023-SITC2023.0529
530 Clinicopathologic features and outcome of patients with microsatellite instable (MSI-H) cancer treated in a Phase I unit
Edoardo Crimini, Matteo Repetto, Angela Esposito, Carmen Belli, Carmen Criscitiello, Marzia Locatelli, Ida Minchella, Eleonora Nicolo’, Luca Boscolo Bielo, Grazia Castellano, Gloria Pellizzari, Stefania Morganti, Pier Paolo Maria Berton Giachetti, Gabriele Antonarelli, Liliana Ascione, Carmine Valenza, Paolo Tarantino, Beatrice Taurelli Salimbeni, Giuseppe Curigliano

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A603-A604; DOI: 10.1136/jitc-2023-SITC2023.0530
531 Unravelling mechanisms of resistance to immune checkpoint blockade using a lineage-tracing tool, CaTCH
Shona M Cronin, Jakob Grünewald, Anna Obenauf

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A605; DOI: 10.1136/jitc-2023-SITC2023.0531
532 A cross-cohort examination of factors impacting immunotherapy survival in non-small cell lung cancer (NSCLC)
Konstantin Danilov, Dhruv Bansal, Ivan Valiev, Vladimir Kushnarev, Chris Ward, Ammar Al-Obaidi, Timothy Pluard, Artem Tarasov, Anastasiia Makarova, Anna Butusova, Anna Love, Krystle Nomie, Nikita Kotlov, Janakiraman Subramanian, Alexander Bagaev

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A606; DOI: 10.1136/jitc-2023-SITC2023.0532
533 Survival mechanisms common to immunotherapy and drug tolerant persister tumor cells
Maria Davern, Brenda Chan, Lara Bencsics, Jasmine Yun-Tong Kung, Michael Yorsz, Gabriella Stone, Michael Olson, Patrick Lizotte, Cloud Paweletz, Patrick Bhola, Marcela Maus, David Barbie, Anthony Letai

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A607; DOI: 10.1136/jitc-2023-SITC2023.0533
534 Responses to immunotherapy based on programmed death-ligand 1 (PD-L1) copy number variation (CNV) status in patients with advanced non-small cell lung cancer (NSCLC)
Aakash Desai, Julia Naso, Caleb Smith, Yash Ashara, Beth Pitel, Anastasios Dimou, Kaushal Parikh, Aaron Mansfield, Julian Molina, Konstantinos Leventakos, Ying-Chun Lo

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A608-A609; DOI: 10.1136/jitc-2023-SITC2023.0534

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