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556 Establishment of a novel preclinical model for evaluating immune checkpoint blockade-induced antitumor immunological memory in lung cancer
Takuro Noguchi, Hitoki Arisato, Akihiko Shiiya, Ichiro Kinoshita, Hirotoshi Akita

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A635; DOI: 10.1136/jitc-2023-SITC2023.0556
557 Chronicity of exposure and ensuing resistance to platinum chemotherapy sensitizes homologous recombination-deficient pancreatic ductal adenocarcinoma to immune checkpoint blockade
Ifeanyichukwu Ogobuiro, Anna Bianchi, Lucas Caeiro, Haleh Amirian, Luis Alberto Nivelo, Iago De Castro Silva, Karthik Rajkumar, Andrew Adams, Vanessa Garrido, Samara Singh, Nagaraj Nagathihalli, Nipun Merchant, Jashodeep Datta

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A636; DOI: 10.1136/jitc-2023-SITC2023.0557
558 A systematic review of anti-drug antibodies related to CTLA-4, PD-1 or PD-L1 inhibitors across tumour types
David J Pinato, Peter R Galle, Catherine R Mitchell, Kerigo Ndirangu, Zahra Ramji, Gabrielle Redhead, Richard Finn

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A637-A638; DOI: 10.1136/jitc-2023-SITC2023.0558
559 Molecular characterization of Merkel cell carcinoma and association with Merkel cell polyomavirus
Varsha Prakash, Sharon Wu, Alex Farrell, Ling Gao, Sourat Darabi, Curtis Perry, Kelsey Poorman, Farah Abdulla, Soo Park

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A639; DOI: 10.1136/jitc-2023-SITC2023.0559
561 Targeting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy
Or-Yam Revach, Angelina Cicerchia, Moshe Sade-Feldman, Seth Anderson, Boryana Petrova, Ofir Shorer, Lloyd Bod, Arnav Mehta, Giulia Cattaneo, Payal Tiwari, Tatyana Sharova, Hongyan Xie, William Michaud, Martin Rasmussen, Jacy Fang, Soldano Ferrone, Keith Flaherty, Genevieve M Boland, Debattama R Sen, Keren Yizhak, Naama Kanarek, Robert T Manguso, Nir Hacohen, Russell Jenkins

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A640; DOI: 10.1136/jitc-2023-SITC2023.0561
562 Combined spatial and transcriptomic analysis identifies immune microenvironment factors associated with checkpoint inhibition response in triple negative breast cancer
Brooke Robertson, Matthew Loya, Wei Han, Angelo Harris, Clifton Drew, Chung-Wein Lee, Mohammed Qutaish, Nora Pencheva, Patrick Franken, Louise Koopman, Mark Fereshteh, Omar Jabado

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A641; DOI: 10.1136/jitc-2023-SITC2023.0562
563 A case series of neoadjuvant ipilimumab and nivolumab in 2 patients with locoregional mucosal melanoma
Christopher Rodman, Daniel J Olson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A642; DOI: 10.1136/jitc-2023-SITC2023.0563
565 Effect of non-overlapping mutations in BRAF, NRAS or NF1 on long-term survival after checkpoint inhibitor-based treatment for metastatic melanoma
Wolfram Samlowski, Alyssa Panning, Gabriel Allred

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A643; DOI: 10.1136/jitc-2023-SITC2023.0565
567 Merkel cell carcinomas are infiltrated by tumor-associated macrophages that counteract intratumoral CD8 T-cell benefit and correlate with resistence to PD-1 pathway blockade
Shira Tabachnick-Cherny, Thomas Pulliam, Haroldo Rodriguez Chevez, Xinyi Fan, Daniel S Hippe, Daniel C Jones, Ata Moshiri, Kimberly S Smythe, Rima Kulikauskas, Lisa Zaba, Kelly Paulson, Paul Nghiem

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A644; DOI: 10.1136/jitc-2023-SITC2023.0567
568 Tumor-intrinsic Sox2 signaling induces regulatory T cell-mediated CD8 T cell exclusion, promoting resistance to checkpoint blockade therapy in lung cancer
Elen Torres, Sally Weng, Kim Nguyen, Ellen Duong, Leon Yim, Stefani Spranger

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A645; DOI: 10.1136/jitc-2023-SITC2023.0568

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