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758 Biomarkers associated with blockade of prostaglandin E2 signaling by TPST-1495: a novel, dual-antagonist of E-prostanoid receptors 2 and 4
Nathan Standifer, Yonchu Jenkins, Sam Whiting, Thomas Dubensky

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A854; DOI: 10.1136/jitc-2023-SITC2023.0758
759 ADPORT-601 (TT-10–101): first-in-human study of adenosine 2A (A2A) and adenosine 2B (A2B) receptor antagonists in participants with selected advanced solid tumors
Sumit Subudhi, Gerald S Falchook, Mohamad A Salkeni, Anthony El-Khoueiry, Jaspreet Grewal, William Tester, Russell Pachynski, Samik Upadhaya, Ana Rosa Saez Ibanez, Sushant Kumar, Kasim Mookhtiar, Desa Rae Stanton-Pastore, Robert Kramer, Justin Fairchild, Ian Walters, Lawrence Fong

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A855; DOI: 10.1136/jitc-2023-SITC2023.0759
760 Interim PK/PD, safety and efficacy data of monotherapy dose escalation of a phase 1/2 study with MDNA11 in patients with advanced solid tumors
Minh D To, Rosemina Merchant, Victoria Atkinson, Philippe Bedard, Warren Brenner, Melissa Coello, Jesus Fuentes Antras, Carole Galligan, Charlotte Lemech, Peter Lloyd, Sudhir Madduri Karanam, Kim Margolin, Matthen Mathew, Amy Prawira, Sajeve Thomas, Przemyslaw Twardowski, Arash Yavari, Fahar Merchant

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A856; DOI: 10.1136/jitc-2023-SITC2023.0760
762 A first-in-human phase 1 clinical study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the EDB+FN targeting ADC PYX-201 in participants with advanced solid tumors
Sharon Wilks, Benedito Carneiro, Gregory Cote, Jason Henry, Shiraj Sen, Alexander I Spira, Frank Yung-Chin Tsai, Judy S Wang, Marsha Crochiere, Shui He, Sondra Smyrnios, Dipali Unadkat, Bin Zhang, Anthony W Tolcher

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A857; DOI: 10.1136/jitc-2023-SITC2023.0762
763 Initial results from phase I dose escalation trial of CAN1012 in patients with solid tumor malignancies
Henry Yu, Herui Yao, Ning Li, Shuhang Wang, Brendan Curti, Giorgio Massimini, Ming-Hong Hu, William L Redmond, Rongliang Lou, Wanping Geng, Sanlong Wang, Meiling Zhang, Rongchu Chen, Baotian Qin, John Mao, Shaoshan Wang, Erwei Song

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A858; DOI: 10.1136/jitc-2023-SITC2023.0763
764 A phase 1, first-in-human (FIH), open-label, dose-finding and expansion study of XmAb808, a B7H3 x CD28 bispecific antibody, in combination with pembrolizumab in patients with advanced solid tumors
Manojkumar Bupathi, Judy S Wang, Siwen Hu-Lieskovan, Sarina A Piha-Paul, Bartosz Chmielowski, Benjamin Garmezy, Yana G Najjar, Mark N Stein, Li Yao, Jitendra Kanodia, Raphael Clynes, Patricia McGovern, Benjamin Thompson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A859; DOI: 10.1136/jitc-2023-SITC2023.0764
765 NG-350A, a tumor-selective anti-CD40 agonist expressing therapeutic, gemcitabine/nab-paclitaxel and ipilimumab for untreated metastatic pancreatic adenocarcinoma: cohort C of the REVOLUTION trial
Eileen M O’Reilly, Mark H O’Hara, George Fisher, Robert A Wolff, Zev A Wainberg, Andrew H Ko, Jamie Arnott, Christopher R Cabanski, Samik Upadhaya, Ana Rosa Saez-Ibanez, Jay Campbell, James Francis, Oliver Rosen, Samantha Bucktrout, Silvia Boffo, Ute Dugan, Jill O’Donnell-Tormey, Robert H Vonderheide, Danny Khalil

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A860; DOI: 10.1136/jitc-2023-SITC2023.0765
766 A clinical trial to evaluate the safety, tolerability and preliminary efficacy of VG161 in combination with Nivolumab in patients with advanced pancreatic cancer
Yinan Shen, Aijun Qin, Yiting Qiu, Xinyan Jin, Wei Song, Tian Fang, Xingmei Liang, Yuwei Li, Qian Tan, Ronghua Zhao, Xueli Bai, Tingbo Liang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A861; DOI: 10.1136/jitc-2023-SITC2023.0766
767 Pre-clinical and first-in-human studies of HCW9218, a bifunctional TGF-β antagonist/IL-15 protein complex, in advanced solid tumors
Melissa A Geller, Manish Patel, Hing C Wong, Peter R Rhode, Philip M Arlen, Danieska Sandino, Karen L Kage, Delsy G Gaetano, Jack O Egan, Giles M Leclerc, Pallavi Chaturvedi, Niraj Shrestha, Zhu Xiaoyun, Martin Felices, Shannon Lunn, Bethany Hanke, Kelsey Mullen, Deepa Kolaseri Krishnadas, Rose Wangen, Jeffrey S Miller

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A862; DOI: 10.1136/jitc-2023-SITC2023.0767
768 Transcriptional profiling of Merkel cell carcinoma that escaped polyomavirus-specific TCR-engineered T cells reveals actionable immunotherapy approaches
Yuta Asano, Joshua Veatch, Bo Lee, Lauren Martin, Jakob Bakhtiari, Valentin Voillet, Brandon Seaton, Cecilia CS Yeung, Thomas M Schmitt, Philip D Greenberg, Paul Nghiem, Aude Chapuis

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A863; DOI: 10.1136/jitc-2023-SITC2023.0768

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