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783 Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: a report from the International RRD consortium
Anirban Das, Nicholas Fernandez, Adrian Levine, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Trevor Pugh, Derek Tsang, Birgit Ertl-Wagner, Daniel Morgenstern, Cynthia Hawkins, Eric Bouffet, Uri Tabori

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A880; DOI: 10.1136/jitc-2023-SITC2023.0783
784 Biomarkers of perioperative immunotherapy in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction adenocarcinoma
Yue Wang, Yawei Chen, Ju Yang, Xiaoyu Zhou, Yutao Wei, Qin Liu, Yang Yang, Wenxian Guan, Baorui Liu, Jia Wei

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A881; DOI: 10.1136/jitc-2023-SITC2023.0784
785 mAZD0171 mediated LIF blockade in combination with chemotherapy and PD-L1 inhibition repolarizes macrophages and increases T cell infiltration via CX3CR1-CX3CL1 axis
Juliana Candido, Gozde Kar, Grace Opoku-Ansah, Scott Hoffmann, Fabien Garcon, Chelsea Gerada, Bairu Zhang, Michal Sulikowski, Rakesh Choudhary, Jean-Martin Lapointe, Douglas C Palmer, Stewart Jones, Robert Wilkinson, Scott Hammond, Nadia Luheshi, Jim Eyles

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A882; DOI: 10.1136/jitc-2023-SITC2023.0785
787 AB598, a CD39 inhibitory antibody, promotes immune-mediated tumor control
Julie Clor, Ke Jin, Kaustubh Parashar, Amy E Anderson, Lance Kates, Yihong Guan, Sam Schwager, Priyanka Talukdar, Ritu Kushwaha, Janine Kline, Ester Fernandez-Salas, Christine Bowman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A883; DOI: 10.1136/jitc-2023-SITC2023.0787
788 Improved immunologic and therapeutic activity of anchored interleukin (IL-12) immunotherapy in combination with cytotoxic chemotherapy and immune checkpoint inhibitor in a head and neck cancer model
Kellsye Fabian, Ginette Santiago-Sanchez, Sailaja Battula, Leisha A Emens, Howard Kaufman, Jeffrey Schlom, James Hodge

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A884; DOI: 10.1136/jitc-2023-SITC2023.0788
789 Immune checkpoint blockade augments cyclophosphamide induced anti-tumor immunity by expanding effector CD8⁺ T cell clones in a preclinical melanoma model
Mariam M George, Linda Hamadene, Nicholas J Ceglia, Yacine Marouf, Daniel Hirschhorn, Alan N Houghton, Jedd D Wolchok, Allison B Warner, Taha Merghoub

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A885; DOI: 10.1136/jitc-2023-SITC2023.0789
790 Paclitaxel can modulate the functional feature of tumor-associated macrophage and consequently enhance the efficacy of immunotherapy in triple-negative breast cancer
Sohee Kang, Jisoo Hong, Hanul Jung, Eunhae Kim, Yoonjeong Choi, Gi-Hoon Nam, Minsu Kwon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A886; DOI: 10.1136/jitc-2023-SITC2023.0790
791 Treatment patterns and real-world clinical outcomes of first-line anti-PD(L)1-based combination therapy among patients with non-squamous metastatic non-small cell lung cancer in Japan
Ticiana A Leal, Anandaroop Dasgupta, Dominick Latremouille-Viau, Carmine Rossi, Pragya Rai, Fabrice Barlesi, Stephen V Liu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A887-A888; DOI: 10.1136/jitc-2023-SITC2023.0791
792 Givastomig, a novel Claudin18.2/4–1BB bispecific antibody, exerts bystander tumor-killing and synergistic anti-tumor activity with therapeutics in 1L/2L treatment for gastric cancer
Xuejun Liu, Ke Xu, Jane Meng, Jie Xia, Chenyu Pan, Ao Li, Zhenhu Li, Zhengyi Wang, Jaeho Jung, Andrew Zhu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A889; DOI: 10.1136/jitc-2023-SITC2023.0792
794 Pulsed electrical field therapy addition to systemic paradigms increases circulating tumor immunity and improves outcomes in drug-resistant murine solid tumors
Ebtesam Nafie, Chiara Pastori, Mukta Wagh, Fatima Murad, Robert Neal

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A891-A892; DOI: 10.1136/jitc-2023-SITC2023.0794

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