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807 A vaccine targeting the recurrent driver mutation H3K27M induces mutation specific T- and B- cell responses in patients with diffuse midline Gliomas
Tamara Boschert, Taga Lerner, Kristina Kromer, Katharina Lindner, Isabel Poschke, Iris Mildenberger, Gordon Haltenhof, Katharina Sahm, John Lindner, Edward Green, Michael Platten

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A905; DOI: 10.1136/jitc-2023-SITC2023.0807
808 The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances responses to anti-PD-1 immunotherapy
Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Ping Hua, Shao-Hsi Hung, Michael A Davies, Gregory A Lizee, Ulrich von Andrian, Patrick Hwu, Gordon Freeman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A906; DOI: 10.1136/jitc-2023-SITC2023.0808
809 A bispecific antibody targeting CCR8 & CTLA-4: Potent anti-tumor efficacy with better safety by preferentially eliminating tumor-infiltrating regulatory T cells
Liandi Chen, Tianhang Zhai, Weifeng Huang, Xiaoniu Miao, Shuang Dai, Shaogang Peng, Chao Wang, Andy Tsun, Yi Luo

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A907; DOI: 10.1136/jitc-2023-SITC2023.0809
810 NX-1607, a small molecule inhibitor of CBL-B, enhances anti-PD-1-mediated tumor growth inhibition by reshaping intratumoral innate and adaptive immune response
Marilena Gallotta, Jose Gomez Romo, Serena Ranucci, Ernestine Lee, Alexandra Borodovsky, Gwenn M Hansen, Arthur T Sands, Ryan Rountree, Cristiana Guiducci

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A908; DOI: 10.1136/jitc-2023-SITC2023.0810
811 Transient EZH2 suppression by tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy
Yingqin Hou, Peng Wu, PI

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A909; DOI: 10.1136/jitc-2023-SITC2023.0811
812 Reprograming of tumor-associated myeloid cells by TLR9-targeted STAT3 antisense oligonucleotides sensitizes malignant glioma to PD1-specific immunotherapy
Chia-Yang Hung, Elaine Kang, Karol Jacek, Chunsong Yu, Xiaowei Zhang, Susanta Hui, Behnam Badie, Bozena Kaminska, Amy Heimberger, Marcin Kortylewski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A910; DOI: 10.1136/jitc-2023-SITC2023.0812
813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro
Andrea Imle, Isil Altintas, Kristina Nuermberger, Jordan Blum, Anna-Lena Krause, Aras Toker, Lidia Daszkiewicz, Alexander Muik, Friederike Gieseke, Tahamtan Ahmadi, Sina Fellermeier-Kopf, Kristel Kemper, Oezlem Tuereci, Esther Breij, Ugur Sahin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A911; DOI: 10.1136/jitc-2023-SITC2023.0813
814 Enhancing anti-tumor response in ICI-refractory non-small cell lung cancer through intravenous administration of oncolytic adenovirus armed with hTNFα and hIL-2 in combination with aPD-1 blockade
Tatiana V Kudling, James Clubb, Santeri A Pakola, Dafne Alves Quixabeira, Iris Lähdeniemi, Camilla Heiniö, Victor Arias, Susanna AM Grönberg-Vähä-Koskela, Riikka Havunen, Victor Cervera-Carrascon, Joao Manuel Santos, Eva Sutinen, Jari Räsänen, Kristian Borenius, Mikko Mäyränpää, Eero Altonen, Suvi Sorsa, Otto Hemminki, Anna Kanerva, Emmy W Verschuren, Ilkka Ilonen, Akseli Hemminki

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A912; DOI: 10.1136/jitc-2023-SITC2023.0814
816 NT-I7 and hIL-2/TCB2c combination promotes an immune-stimulatory tumor microenvironment that favors anti-tumor efficacy in combination with checkpoint inhibitors
Minji Lee, Sara Ferrando-Martinez, Sun-Kyoung Im, Seungtae Baek, Mankyu Ji, Miyoung Kim, Eunju Lee, Seung Taek Ji, Daeun Kim, Jun-Young Lee, Donghoon Choi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A914; DOI: 10.1136/jitc-2023-SITC2023.0816
817 AST-201 (pUMVC3-hIGFBP2 N-terminus) demonstrates anti-tumor effect in an ovarian cancer mouse model
Jinback Lim, Hyo-Hyun Park, Jin Kyeong Choi, Jee Hyun Choi, JinHo Kang, Seong-Yong Jang, Min-Ah Kim, Myeong-Kyu Park, Mary L Disis, Eunkyo Joung, Hun Jung

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A915; DOI: 10.1136/jitc-2023-SITC2023.0817

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