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1205 Surmounting conventional cell therapy limitations via in situ CAR therapy using oRNA™ lipid nanoparticles
Amy Becker, Alex Wesselhoeft, Allen Horhata, Akinola Emmanuel, Kevin Kauffman, Sharmistha Kundu, Thomas Lee, David Soto, Akshi Thakkar, Ramya Elangovan, Magnolia Chinn, Renee Wright-Michaud, Meghan Richardson, Chris Wright, Kristen Ott, Jui Dutta-Simmons, Rena Schindler, Trent Stevens, Yessica Wiryawan, Ashley Wong, Ian Langer, Rahul Vungutur, Corey Ciullo, Junghoon Yang, Paisley Haskell, Nelson Chau, Thomas Barnes, Robert Mabry

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1329; DOI: 10.1136/jitc-2023-SITC2023.1205
1206 Immunometabolic modulation of engineered iPSC-NK cells for immunotherapy of solid tumors
Shambhavi Borde, Sandro Matosevic

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1330; DOI: 10.1136/jitc-2023-SITC2023.1206
1207 A new oral microbial metabolite prodrug preserves CD8⁺ T cell stemness and improves the antitumor efficacy of immune checkpoint blockers
Youngseok Cho, Kai Han, James J Moon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1331; DOI: 10.1136/jitc-2023-SITC2023.1207
1208 A multimodal cytokine effects atlas from multiplexed cell barcoding reveals principles of T cell programming
Elisa C Clark, Sriram Pendyala, Kathleen Abadie, Matthew Wither, Arjun Kumar, Douglas Fowler, Hao Yuan Kueh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1332; DOI: 10.1136/jitc-2023-SITC2023.1208
1209 Mechanisms of post-immunotherapy efficacy enhancement by tumor lymphangiogenesis
Colleen Foley, Lambert Potin, Trevin Kurtanic, Melody Swartz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1333; DOI: 10.1136/jitc-2023-SITC2023.1209
1210 The potential of membrane-tethered IL-2 agonists in overcoming CAR T cell exhaustion
Diana Gumber, Leo Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1334; DOI: 10.1136/jitc-2023-SITC2023.1210
1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
Latambria Hampton, Lora J Rogers, Michael A Bauer, Daniel Fil, Jessica L Kelliher, Sydnye L Shuttleworth, Emilie Darrigues, Analiz Rodriguez, Brian Koss

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1335; DOI: 10.1136/jitc-2023-SITC2023.1211
1212 Bioengineered tumour-targeted interleukin-12 selectively cures murine triple-negative breast cancer (TNBC)
Melanie Herpels, Chanthirika Ragulan, Aslan Mansurov, Jun Ishihara, Anguraj Sadanandam

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1336; DOI: 10.1136/jitc-2023-SITC2023.1212
1213 Tumor-ECM targeted IL-12: improved safety and efficacy in clinically relevant settings
Jun Ishihara

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1337-A1338; DOI: 10.1136/jitc-2023-SITC2023.1213
1214 IL-12 vectors engineered to encode a functional p35-p40 heterodimer or a single p35 subunit for cancer immunotherapy
Robert Johnson, Cecilia Roh, Jacqueline Fischer-Lougheed, Stephanie Lees

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1339; DOI: 10.1136/jitc-2023-SITC2023.1214

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