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1437 Proteomic profiling of tumor microenvironment in desmoplastic melanoma using the nanostring geomx digital spatial profiler
David Su, David A Schoenfeld, Wael Ibrahim, Raymond Baumann, David Rimm, Harriet Kluger, Kelly Olino, Anjela Galan, Jim Clune

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1600; DOI: 10.1136/jitc-2023-SITC2023.1437
1438 Stromal hypersialylation within colorectal tumors contributes to immunosuppression of T cell adaptive immunity in the tumor microenvironment
Oliver Treacy, Jenny Che, Wayne Gatlin, Lizhi Cao, Hannah Egan, Aoise O’Neill, Michael O’Dwyer, Pushpa Jayaraman, Li Peng, Aideen E Ryan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1601; DOI: 10.1136/jitc-2023-SITC2023.1438
1439 Novel cancer-associated fibroblast-related markers mediate antitumor immunity in colon cancer
Leqian Ying, Lin Liu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1602; DOI: 10.1136/jitc-2023-SITC2023.1439
1440 Shaping the immunometabolism of HR+ breast cancer with kynurenamines
Aitziber Buque Martinez, Cristina Clement, Norma Bloy, Ai Sato, Madhur Shetty, Laura Santambrogio

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1603; DOI: 10.1136/jitc-2023-SITC2023.1440
1441 The glucocorticoid receptor (GR)-dependent regulations of chronic inflammation and NRF2 as emerging drug targets for cancer therapy
Min-Ji Choi, Hyun-Taek Oh, Eun-Ji Choi, Jun-Goo Jee, Sang-Min Jeon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1604; DOI: 10.1136/jitc-2023-SITC2023.1441
1442 Exploring novel ferroptosis inducer as a promising strategy for sarcoma treatment
Maria Cristina Munteanu, Taronish Dubash, Cristian Nunez, Shrouq Farah, Gabriel Brown, Aesha Upadhyay, Branko Radetich, Yeon Sook Choi, Francesco Marincola, Darby Schmidt, Nadia Gurvich

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1605; DOI: 10.1136/jitc-2023-SITC2023.1442
1443 Immunoediting drives MYC related metabolic reprogramming for cancer immune evasion through non-canonical IFNγ-STAT3 pathway
Chin-Hsien Tsai, Yu-Ming Chuang, Susan Kaech, Ping-Chih Ho

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1606; DOI: 10.1136/jitc-2023-SITC2023.1443
1444 Pharmacologic LDH inhibition redirects intratumoral glucose consumption and improves response to CTLA-4 blockade
Svena Verma, Roberta Zappasodi, Sadna Budhu, Inna Serganova, Lauren Dong, Levi Mark Mangarin, Yacine Marouf, Jonathan F Khan, Jedd D Wolchok, Taha Merghoub

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1607; DOI: 10.1136/jitc-2023-SITC2023.1444
1445 Breast tumor cell heme metabolism alters macrophage immune suppression and function to support lung metastasis
Michelle M Williams, Sabrina Hafeez, Jessica Christenson, Nicole S Spoelstra, Kathleen I O’Neill, Li-Wei Kuo, Lyndsey Crump, Jill E Slansky, Jennifer K Richer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1608; DOI: 10.1136/jitc-2023-SITC2023.1445
1446 Pan-cancer methylation analysis reveals a significant correlation of immune-desert phenotype with methylation aberrancy
Sanghoon Song, Seulki Kim, Seonwook Park, Jinhee Lee, Sergio Pereira, Chang Ho Ahn, Siraj Ali, Chan-Young Ock

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1609; DOI: 10.1136/jitc-2023-SITC2023.1446

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