Open access

161 Development of a CD8 co-receptor independent T cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T cell-based immunotherapy
Kathrin Davari, Tristan Holland, Laura Prassmayer, Giulia Longinotti, Kenneth Ganley, Lisa Pechilis, Iulia Diaconu, Prashant Nambiar, Mike Magee, Dolores Schendel, Daniel Sommermeyer, Christian Ellinger, Rer Nat

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A97; DOI: 10.1136/jitc-2020-SITC2020.0161
163 Nice: neoantigen-cytokine-chemokine multifunctional engager for NK cell immunotherapy of solid tumors
Xue Yao, Sandro Matosevic

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A97-A98; DOI: 10.1136/jitc-2020-SITC2020.0163
165 Activating antigen carriers generated with microfluidics cell squeezing drive effective anti-tumor responses
Katarina Blagovic, Amritha Ramakrishnan, Armon Sharei, Howard Bernstein, Katherine Seidl, Defne Yarar

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A98-A99; DOI: 10.1136/jitc-2020-SITC2020.0165
167 B-cell-based vaccination elicit potent immunity against glioblastoma
Catalina Lee-Chang, Jason Miska, David Hou, Aida Rashidi, Peng Zhang, Rachel Burga, Crag Horbinski, Roger Stupp, Maciej Lesniak

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A99-A101; DOI: 10.1136/jitc-2020-SITC2020.0167
166 Mucosal-associated invariant T-cells (MAIT) in pancreatic cancer
Jéssica Kamiki, Patrícia António, Pedro Noronha, Carolina Condeço, Georgia Paraschoudi, Eric De Sousa, Andreia Maia, Mireia Castillo-Martin, Antonio Beltran, Carlos Carvalho, Joana Lérias, Markus Maeurer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A99; DOI: 10.1136/jitc-2020-SITC2020.0166
170 Microfluidics cell squeezing enables potent cellular vaccines in murine models through direct cytosolic loading and direct CD8 T cell priming
Emrah Ozay, Matthew Booty, Katarina Blagovic, David Soto, Olivia Pryor, Adam Stockmann, Disha Subramanya, Kelly Volk, Armon Sharei, Howard Bernstein, Defne Yarar, Katherine Seidl, Scott Loughhead

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A102; DOI: 10.1136/jitc-2020-SITC2020.0170
174 An ex vivo tumoroid model of fresh patient tumors (3D-ACT) to assess efficacy of cellular therapy in immuno-oncology
Stephen Iwanowycz, Jared Ehrhart, Mibel Pabon, Tina Pastoor, Jenny Kreahling, Soner Altiok

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A104; DOI: 10.1136/jitc-2020-SITC2020.0174
241 Clinical outcomes of metastatic melanoma patients with liver metastases treated with anti-PD-1 monotherapy versus combination ipilimumab/nivolumab
Vincent Ma, Kent Griffith, Jessica Waninger, Stephanie Daignault-Newton, Leslie Fecher, Ajjai Alva, Christopher Lao

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A143-A144; DOI: 10.1136/jitc-2020-SITC2020.0241
243 Real world exposure survival relationship of pembrolizumab in metastatic melanoma
Vishal Navani, Moira Graves, Giovana Marchett, Hiren Mandaliya, Nikola Bowden, Andre Van der Westhuizen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A144-A145; DOI: 10.1136/jitc-2020-SITC2020.0243
246 Clinicopathologic and genomic correlates of tumor mutational burden and its impact on PD-(L)1 inhibition efficacy in non-small cell lung cancer according to different PD-L1 expression subgroups
Biagio Ricciuti, Navin Mahadevan, Renato Umeton, Joao Alessi, Andrew Polio, Natalie Vokes, Giulia Leonardi, Elizabeth Aguilar, Gonzalo Recondo, Giuseppe Lamberti, Marissa Lawrence, Pasi Janne, Eliezer Van Allen, Lynette Sholl, Mark Awad

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A147-A149; DOI: 10.1136/jitc-2020-SITC2020.0246

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