Open access

670 Develop a multiplex immunofluorescence panel to identification of distinct complex immune landscapes in pleural effusion liquids from patients with metastatic lung adenocarcinoma
Caddie Laberiano, Luisa Solis, Sinchita Roy Chowdhuri, Edwin Parra

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A707; DOI: 10.1136/jitc-2020-SITC2020.0670
115 Engineered T cells directed at tumors with defined allelic loss
Agi Hamburger, Breanna DiAndreth, Jiajia Cui, Mark Daris, Melanie Munguia, Kiran Deshmukh, Jee-Young Mock, Grace Asuelime, Emily Lim, Michelle Kreke, Talar Tokatlian, Alexander Kamb

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71; DOI: 10.1136/jitc-2020-SITC2020.0115
117 Rapid point-of-care subcutaneous CAR-T from blood draw to injection in 4 hours with modified LV encoding CARs and synthetic driver elements enables efficient CAR-T expansion and tumor regression
Frederic Vigant, Qun He, Wei Zhang, Hongliang Zong, Anirban Kundu, Ewa Jaruga-Killeen, Gregory Schreiber, Michelle Andraza, Alissa Kerner, Gregory Frost

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A72; DOI: 10.1136/jitc-2020-SITC2020.0117
119 IL-6 is critical for memory responses elicited by Th17 cells to tumors
Hannah Knochelmann, Connor Dwyer, Aubrey Smith, Megan Wyatt, Guillermo Rangel RIvera, Gregory Lesinski, Zihai Li, Mark Rubinstein, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A72-A73; DOI: 10.1136/jitc-2020-SITC2020.0119
120 P-MUC1C-ALLO1: An allogeneic car-t for multiple solid tumor indications
Anna Kozlowska, Yan Zhang, Jacqueline Fritz, Steven Wang, Rebecca Codde, Elvira Argus, Samad Ibitokou, Vanitra Richardson, Sumiti Jain, Maximilian Richter, Deepak Patil, Yening Tan, Min Tong, Lu Yao, Majid Ghoddusi, Eric Ostertag, Julia Coronella, Devon Shedlock

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A73; DOI: 10.1136/jitc-2020-SITC2020.0120
122 Guanylyl cyclase C as a target for CAR-T cell therapy in a metastatic gastric cancer model
Amanda Lisby, Trevor Baybutt, Megan Weindorfer, Robert Carlson, Alicja Zalewski, Scott Waldman, Adam Snook

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A73-A74; DOI: 10.1136/jitc-2020-SITC2020.0122
125 Reexamination of MAGE-A3 as a T-cell Therapeutic Target
Aaron Martin, Xueyin Wang, Han Xu, Alexander Kamb, Mark Sandberg, Kathleen Negri, Ming Wu, Dora Toledo Warshaviak, Grant Gabrelow, Michele Mcelvain, Mark Daris, Bella Lee

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A76; DOI: 10.1136/jitc-2020-SITC2020.0125
126 Early-phenotype Lewis Y CAR-T cells persist better in vivo and induce solid tumor regression in combination with anti-PD1
Deborah Meyran, Joe Zhu, Jeanne Butler, Sean Macdonald, Daniela Tantalo, Niko Thio, Kevin Sek, Paul Ekert, Michael Kershaw, Joe Trapani, Phillip Darcy, Paul Neeson

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A76-A78; DOI: 10.1136/jitc-2020-SITC2020.0126
732 Chemerin reactivates PTEN and suppresses PD-L1 in tumor cells via a novel CMKRL1-mediated pathway
Russell Pachynski, Keith Rennier, Woo Jae Shin, Ethan Krug, Gurpal Virdi, Russell Pachynski

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A776; DOI: 10.1136/jitc-2020-SITC2020.0732
128 Development of an M1-polarized, non-viral chimeric antigen receptor macrophage (CAR-M) platform for cancer immunotherapy
Yumi Ohtani, Kayleigh Ross, Aditya Dandekar, Rashid Gabbasov, Michael Klichinsky

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A79; DOI: 10.1136/jitc-2020-SITC2020.0128

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