Open access

128 Development of an M1-polarized, non-viral chimeric antigen receptor macrophage (CAR-M) platform for cancer immunotherapy
Yumi Ohtani, Kayleigh Ross, Aditya Dandekar, Rashid Gabbasov, Michael Klichinsky

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A79; DOI: 10.1136/jitc-2020-SITC2020.0128
746 Non small-cell lung cancer cells and cancer-associated fibroblasts drive macrophage polarization in a novel co-culture model
Josiah Flaming, Raghav Chandra, Luc Girard, Debolina Ganguly, Jason Toombs, John Minna, Rolf Brekken

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A793-A794; DOI: 10.1136/jitc-2020-SITC2020.0746
16 Antibody profiling of prostate cancer patients reveals differences in antibody signatures among disease stages and following treatment
Hemanth Potluri, Tun Lee Ng, Michael Newton, Jin Zhang, Christopher Maher, Peter Nelson, Douglas McNeel

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A8-A9; DOI: 10.1136/jitc-2020-SITC2020.0016
130 Immunogenic potential of chimeric antigen receptor (CAR)-engineered T cells expressing inducible nuclease-deactivated SpCas9 (dCas9)
Dharmeshkumar Patel, Dharmeshkumar Patel, Angshumala Goswami, Vitaly Balan, Zhifen Yang, Lingyu Li, Sowndharya Rajavel, Alper Kearney, Rona Harari-Steinfeld, Maggie Bobbin, Bing Wang, Alessandra Cesano, Stanley Qi, Francesco Marincola

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A80; DOI: 10.1136/jitc-2020-SITC2020.0130
133 Development of novel cellular therapeutics for metastatic and primary CNS malignancies
Paul Rennert, Alyssa Birt, Lihe Su, Lan Wu, Fay Dufort, Roy Lobb, Christine Ambrose, Paul Rennert

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A81; DOI: 10.1136/jitc-2020-SITC2020.0133
136 Targeting MET with chimeric antigen receptor T cells in hepatocellular carcinoma
Yuan Qin, Anna Qin, Anna Musket, Joseph Lee, Zhi Yao, Giedre Krenciute, Qian Xie

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A82-A83; DOI: 10.1136/jitc-2020-SITC2020.0136
137 Genomics of multiple myeloma influences the expression of CAR T-cell targets
Christina Yu, Brian Walker, G David Roodman, Kun Huang, Michel Sadelain, Fabiana Perna

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A83; DOI: 10.1136/jitc-2020-SITC2020.0137
789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer
Erika Crosby, Hiroshi Nagata, Melinda Telli, Chaitanya Acharya, Irene Wapnir, Kaitlin Zablotsky, Erica Browning, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kellie Malloy, David Canton, Christopher Twitty, Takuya Osada, Herbert Lyerly

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A838; DOI: 10.1136/jitc-2020-SITC2020.0789
139 Establishment of canine CAR T cells treatment model for solid tumor immunotherapy development
Shihong Zhang, Karan Kohli, R Graeme Black, Brian Hayes, Cassandra Miller, Mari Maeda-Whitaker, Brett Schroeder, Kraig Abrams, Bernard Seguin, Stephen Gottschalk, Peter Moore, Beverly Torok-Storb, Seth Pollack

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A84-A85; DOI: 10.1136/jitc-2020-SITC2020.0139
793 TG4001 (Tipapkinogene sovacivec) and avelumab for recurrent/metastatic (R/M) human papilloma virus (HPV)-16+ cancers: clinical efficacy and immunogenicity
Christophe Le Tourneau, Philippe Cassier, Frederic Rolland, Sébastien Salas, Jean Marc Limacher, Olivier Capitain, Olivier Lantz, Ana Lalanne, Christina Ekwegbara, Annette Tavernaro, Hakim Makhloufi, Kaidre Bendjama, Jean-Pierre Delord

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A841; DOI: 10.1136/jitc-2020-SITC2020.0793

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